DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec13 and SEC13

DIOPT Version :9

Sequence 1:	NP_001287480.1	Gene:	Sec13 / 44437	FlyBaseID:	FBgn0024509	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_013309.1	Gene:	SEC13 / 850905	SGDID:	S000004198	Length:	297	Species:	Saccharomyces cerevisiae

Alignment Length:	294	Identity:	145/294 - (49%)
Similarity:	196/294 - (66%)	Gaps:	13/294 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IDTEHEDMVHHAALDFYGLLLATCSSDGSVRIFH-SRKNNKALAELKGHQGPVWQVAWAHPKFGN 71
            |...|.:::|.|.||:||..|||||||.:::||. ..:.:|.:..|.||:||||:|.|||||||.
Yeast     4 IANAHNELIHDAVLDYYGKRLATCSSDKTIKIFEVEGETHKLIDTLTGHEGPVWRVDWAHPKFGT 68

  Fly    72 ILASCSYDRKVIVWKSTTPRDWTKLYEYSNHDSSVNSVDFAPSEYGLVLACASSDGSVSVLTCNT 136
            ||||||||.||::||....| |:::..::.|.:|||||.:||.|||.:|..|||||.|||:...
Yeast    69 ILASCSYDGKVLIWKEENGR-WSQIAVHAVHSASVNSVQWAPHEYGPLLLVASSDGKVSVVEFK- 131

  Fly   137 EYGVWDAKKIPNAHTIGVNAISWCPAQAPDPAFDQRVTSRSAAVKRLVSGGCDNLVKIWREDND- 200
            |.|. .:..|.:||.||||:.||.||...:.. :...|..|   ::.|:||.|||||||:.::|
Yeast   132 ENGT-TSPIIIDAHAIGVNSASWAPATIEEDG-EHNGTKES---RKFVTGGADNLVKIWKYNSDA 191

  Fly   201 -RWVEEHRLEAHSDWVRDVAWAPSIGLPRSQIATASQDRHVIVWSSNADLSEWTSTVL--HTFDD 262
             .:|.|..||.||||||||||:|:: |.||.:|:.||||..|:|:.:.:...|..|:|  ..|.|
Yeast   192 QTYVLESTLEGHSDWVRDVAWSPTV-LLRSYLASVSQDRTCIIWTQDNEQGPWKKTLLKEEKFPD 255

  Fly   263 AVWSISWSTTGNILAVTGGDNNVTLWKENTEGQW 296
            .:|..|||.:||:||::||||.|||||||.||:|
Yeast   256 VLWRASWSLSGNVLALSGGDNKVTLWKENLEGKW 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec13	NP_001287480.1	WD40	10..289	CDD:392136	137/283 (48%)
		WD40 repeat	60..101	CDD:293791	23/40 (58%)
		WD40 repeat	106..148	CDD:293791	21/41 (51%)
		WD40 repeat	155..207	CDD:293791	20/53 (38%)
		WD40 repeat	215..256	CDD:293791	18/40 (45%)
		WD40 repeat	264..290	CDD:293791	16/25 (64%)
SEC13	NP_013309.1	WD40	8..282	CDD:421866	137/281 (49%)
		WD40 repeat	57..97	CDD:293791	23/40 (58%)
		WD40 repeat	102..141	CDD:293791	20/40 (50%)
		WD40 repeat	149..197	CDD:293791	19/51 (37%)
		WD40 repeat	207..249	CDD:293791	19/42 (45%)
		WD40 repeat	257..283	CDD:293791	16/25 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344161
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1332
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6479
Inparanoid	1	1.050	278	1.000	Inparanoid score	I571
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53827
OrthoFinder	1	1.000	-	-		FOG0003364
OrthoInspector	1	1.000	-	-		oto99925
orthoMCL	1	0.900	-	-		OOG6_101941
Panther	1	1.100	-	-	LDO	PTHR11024
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1303
SonicParanoid	1	1.000	-	-		X2253
TreeFam	1	0.960	-	-
	14	13.790