Protein Alignment Sec13 and SEH1L

DIOPT Version :10

• Sequence 1: NP_651977.1
• Gene: Sec13 / 44437
• FlyBaseID: FBgn0024509
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: XP_011524044.1
• Gene: SEH1L / 81929
• HGNCID: 30379
• Length: 441
• Species: Homo sapiens
• Alignment Length: 432
• Identity: 118/432 - (27%)
• Similarity: 187/432 - (43%)
• Gaps: 101/432 - (23%)

  Fly     6 QEIDTEHEDMVHHAALDFYGLLLATCSSDGSVRIFHSRKNN--KALAELKGHQGPVWQVAWAHPK 68
            :.|..:|:|::|..:.||:|..:||||||.||:::...::.  ...|..|.|.|.||:|.||||:
Human     5 RSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPE 69

  Fly    69 FGNILASCSYDRKVIVWKSTTPRD---------WTKLYEYSNHDSSVNSVDFAPSEYGLVLACAS 124
            ||.:|||||:||...||:......         |.|.....:..:||..|.|||...||:||..|
Human    70 FGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCS 134

  Fly   125 SDGSVSVLTCNTEYGVWDAKKIPN------AHTI----GVNAISWCPAQAPD--------PAFDQ 171
            :||.|.         :::|..:.|      .|.|    ..:.|||.|::...        ..::.
Human   135 ADGIVR---------IYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSRISKLIEKMNRAHLYNF 190

  Fly   172 RVTSRSAAVKRLVSGGCDN-----LVKI----WREDNDRWVEEHRLEAHSDWVRDVAWAPSIGLP 227
            .:.| |.|...:::.|.|:     :.|:    :.|:..::.:...|...:|.|.|:|:||::|..
Human   191 HIPS-SRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRS 254

  Fly   228 RSQIATASQDRHVIVWSSNADLSEWTST---------VLHTFDD---AVWSISWSTTGNILAVTG 280
            ...:|.|::|  |.:::......|.||:         ::..||:   .||.:||:.||.:||.:|
Human   255 FHILAIATKD--VRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSG 317

  Fly   281 GDNNVTLWKENTEGQW----------IRINYES---------GTAIQSKQ--------------P 312
            .|..|.|||.|....|          ..:|..|         |:.|.|.|              |
Human   318 DDGCVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGRYFFTP 382

  Fly   313 SHLPHSHSQQQQALQQHQQQAPSHPGPSSDSEHSSNLSNSQL 354
            ...|.:.|:    ...:.|..|..|.|.  .|||.:...:.|
Human   383 LDSPRAGSR----WSSYAQLLPPPPPPL--VEHSCDADTANL 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec13	NP_651977.1	WD40	<10..288	CDD:441893	95/327 (29%)
		WD40 repeat	60..101	CDD:293791	19/49 (39%)
		WD40 repeat	106..148	CDD:293791	14/41 (34%)
		WD40 repeat	155..207	CDD:293791	11/68 (16%)
		WD40 repeat	215..256	CDD:293791	13/49 (27%)
		WD40 repeat	264..290	CDD:293791	13/25 (52%)
SEH1L	XP_011524044.1	WD40	<11..348	CDD:441893	100/348 (29%)
		WD40 repeat	15..55	CDD:293791	13/39 (33%)
		WD40 repeat	61..111	CDD:293791	19/49 (39%)
		WD40 repeat	116..149	CDD:293791	14/41 (34%)
		WD40 repeat	166..232	CDD:293791	11/66 (17%)
		WD40 repeat	242..287	CDD:293791	13/46 (28%)
		WD40 repeat	301..340	CDD:293791	16/38 (42%)