DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec13 and sec13

DIOPT Version :9

Sequence 1:	NP_001287480.1	Gene:	Sec13 / 44437	FlyBaseID:	FBgn0024509	Length:	356	Species:	Drosophila melanogaster
Sequence 2:	NP_988967.1	Gene:	sec13 / 394564	XenbaseID:	XB-GENE-944452	Length:	320	Species:	Xenopus tropicalis

Alignment Length:	302	Identity:	183/302 - (60%)
Similarity:	226/302 - (74%)	Gaps:	4/302 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVSLLQEIDTEHEDMVHHAALDFYGLLLATCSSDGSVRIFHSRKNNKAL-AELKGHQGPVWQVAW 64
            |||::..:||.||||:|.|.:|:||..|||||||.||:||..:...:.| |:|:||:||||||||
Frog     1 MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVKNGGQILIADLRGHEGPVWQVAW 65

  Fly    65 AHPKFGNILASCSYDRKVIVWKSTTPRDWTKLYEYSNHDSSVNSVDFAPSEYGLVLACASSDGSV 129
            |||.:||||||||||||||:||... ..|.|.|||:.||||||||.:||.:.||||||.||||::
Frog    66 AHPMYGNILASCSYDRKVIIWKEEN-GTWEKTYEYTGHDSSVNSVCWAPHDLGLVLACGSSDGAI 129

  Fly   130 SVLTCNTEYGVWDAKKIPNAHTIGVNAISWCPAQAPDPAFDQRVTSRSAAVKRLVSGGCDNLVKI 194
            |:|| .|..|.|:.|||.||||||.||:||.|:..|....||..:.:...:||.|||||||||||
Frog   130 SILT-YTGDGPWEVKKISNAHTIGCNAVSWAPSVVPGSLVDQPSSQKPNYIKRFVSGGCDNLVKI 193

  Fly   195 WREDNDRWVEEHRLEAHSDWVRDVAWAPSIGLPRSQIATASQDRHVIVWSS-NADLSEWTSTVLH 258
            |||::.:|.|:.:||||||||||||||||||||.|.||:.|||..|.:|:| :|..:.|...:||
Frog   194 WREEDGQWKEDQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVYIWTSDDAATNCWNPKLLH 258

  Fly   259 TFDDAVWSISWSTTGNILAVTGGDNNVTLWKENTEGQWIRIN 300
            .|:|.||.:|||.|.|||||:||||.||||||:.:|||..|:
Frog   259 KFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWACIS 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec13	NP_001287480.1	WD40	10..289	CDD:392136	172/280 (61%)
		WD40 repeat	60..101	CDD:293791	29/40 (73%)
		WD40 repeat	106..148	CDD:293791	25/41 (61%)
		WD40 repeat	155..207	CDD:293791	26/51 (51%)
		WD40 repeat	215..256	CDD:293791	24/41 (59%)
		WD40 repeat	264..290	CDD:293791	19/25 (76%)
sec13	NP_988967.1	WD40	10..288	CDD:392136	171/279 (61%)
		WD40 repeat	61..101	CDD:293791	29/40 (73%)
		WD40 repeat	106..152	CDD:293791	29/46 (63%)
		WD40 repeat	160..208	CDD:293791	22/47 (47%)
		WD40 repeat	214..256	CDD:293791	24/41 (59%)
		WD40 repeat	264..290	CDD:293791	19/25 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I7946
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H6479
Inparanoid	1	1.050	385	1.000	Inparanoid score	I1984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375879at33208
OrthoFinder	1	1.000	-	-		FOG0003364
OrthoInspector	1	1.000	-	-		oto104480
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1303
SonicParanoid	1	1.000	-	-		X2253
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.090