DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hs2st and Hs2st1

DIOPT Version :9

Sequence 1:	NP_477339.1	Gene:	Hs2st / 44433	FlyBaseID:	FBgn0024230	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	XP_008759717.1	Gene:	Hs2st1 / 292155	RGDID:	1305366	Length:	357	Species:	Rattus norvegicus

Alignment Length:	360	Identity:	178/360 - (49%)
Similarity:	244/360 - (67%)	Gaps:	30/360 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILLRPTHWLILIALCAVTCAGYWLLWSEIRLEHAFKPLSKLGDSLS---------------PDQH 59
            |::.|...|:.:...||.     :|:.|.:::...:..:||..:::               |.|.
  Rat     6 IMMPPKLQLLAVVAFAVA-----MLFLENQIQKLEESRAKLERAIARHEVREIEQRHTMDGPRQD 65

  Fly    60 ASSTTDDFDFEEHLVVLYNRVPKTGSTSFVNIAYDLCKPNKFHVLHINVTANMHVLSLPNQIQFV 124
            |:     .|.||.:|::|||||||.||||.|||||||..|::||||||.|.|..|:||.:|::||
  Rat    66 AT-----LDEEEDIVIIYNRVPKTASTSFTNIAYDLCAKNRYHVLHINTTKNNPVMSLQDQVRFV 125

  Fly   125 RNVSRWHEMKPALYHGHMAFLDFSKFQIAHKPIYINLVRKPLDRLVSYYYFLRFGDNYRPNLVRK 189
            :|::.|:||||..||||:::|||:||.:..||||||:||.|::|||||||||||||:|||.|.|:
  Rat   126 KNITSWNEMKPGFYHGHISYLDFAKFGVKKKPIYINVVRDPIERLVSYYYFLRFGDDYRPGLRRR 190

  Fly   190 KAGNKITFDECVVQKQPDCDPKNMWLQIPFFCGHAAECWEPGSSWALDQAKRNLVNEYFLVGVTE 254
            |.|:|.||||||.:...||.|:.:||||||||||::|||..||.||:||||.|||||||||||||
  Rat   191 KQGDKKTFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQAKYNLVNEYFLVGVTE 255

  Fly   255 QMYEFVDLLERSLPRIFHGFREHYHN-SNKSHLRVTSSKLPPSESTIKSIQKTKIWQMENDLYDF 318
            ::.:|:.|||.:|||.|.|..:.|.. ..|||||.|:.|..|::.||..:|::.||:|||:.|:|
  Rat   256 ELEDFIMLLEAALPRFFRGATDLYRTVGKKSHLRKTTEKKLPTKQTIAKLQQSDIWKMENEFYEF 320

  Fly   319 ALAQFEFNKKKLMQPDNKHV----QKFMYEKIRPK 349
            ||.||:|.:...::..:..:    |.|.||||.||
  Rat   321 ALEQFQFMRAHAVREKDGDLYILAQNFFYEKIYPK 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hs2st	NP_477339.1	Sulfotransfer_2	70..325	CDD:281554	156/255 (61%)
Hs2st1	XP_008759717.1	Sulfotransfer_2	71..327	CDD:281554	156/255 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336834
Domainoid	1	1.000	354	1.000	Domainoid score	I967
eggNOG	1	0.900	-	-		E1_KOG3922
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8025
Inparanoid	1	1.050	365	1.000	Inparanoid score	I2101
OMA	1	1.010	-	-		QHG52295
OrthoDB	1	1.010	-	-		D375927at33208
OrthoFinder	1	1.000	-	-		FOG0005800
OrthoInspector	1	1.000	-	-		oto98373
orthoMCL	1	0.900	-	-		OOG6_107368
Panther	1	1.100	-	-	LDO	PTHR12129
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4188
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770