DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hs2st and Hs2st1

DIOPT Version :9

Sequence 1:	NP_477339.1	Gene:	Hs2st / 44433	FlyBaseID:	FBgn0024230	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	NP_001342163.1	Gene:	Hs2st1 / 23908	MGIID:	1346049	Length:	357	Species:	Mus musculus

Alignment Length:	360	Identity:	175/360 - (48%)
Similarity:	244/360 - (67%)	Gaps:	30/360 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILLRPTHWLILIALCAVTCAGYWLLWSEIRLEHAFKPLSKLGDSLS---------------PDQH 59
            |::.|...|:.:...||.     :|:.|.:::...:..:||..:::               |.|.
Mouse     6 IMMPPKLQLLAVVAFAVA-----MLFLENQIQKLEESRAKLERAIARHEVREIEQRHTMDGPRQD 65

  Fly    60 ASSTTDDFDFEEHLVVLYNRVPKTGSTSFVNIAYDLCKPNKFHVLHINVTANMHVLSLPNQIQFV 124
            |:     .|.||.::::|||||||.||||.|||||||..|::||||||.|.|..|:||.:|::||
Mouse    66 AT-----LDEEEDIIIIYNRVPKTASTSFTNIAYDLCAKNRYHVLHINTTKNNPVMSLQDQVRFV 125

  Fly   125 RNVSRWHEMKPALYHGHMAFLDFSKFQIAHKPIYINLVRKPLDRLVSYYYFLRFGDNYRPNLVRK 189
            :|::.|:||||..||||:::|||:||.:..||||||::|.|::|||||||||||||:|||.|.|:
Mouse   126 KNITTWNEMKPGFYHGHISYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRR 190

  Fly   190 KAGNKITFDECVVQKQPDCDPKNMWLQIPFFCGHAAECWEPGSSWALDQAKRNLVNEYFLVGVTE 254
            |.|:|.||||||.:...||.|:.:||||||||||::|||..||.||:||||.||:||||||||||
Mouse   191 KQGDKKTFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQAKSNLINEYFLVGVTE 255

  Fly   255 QMYEFVDLLERSLPRIFHGFREHYHN-SNKSHLRVTSSKLPPSESTIKSIQKTKIWQMENDLYDF 318
            ::.:|:.|||.:|||.|.|..:.|.. ..|||||.|:.|..|::.||..:|::.||:|||:.|:|
Mouse   256 ELEDFIMLLEAALPRFFRGATDLYRTVGKKSHLRKTTEKKLPTKQTIAKLQQSDIWKMENEFYEF 320

  Fly   319 ALAQFEFNKKKLMQPDNKHV----QKFMYEKIRPK 349
            ||.||:|.:...::..:..:    |.|.||||.||
Mouse   321 ALEQFQFIRAHAVREKDGDLYILAQNFFYEKIYPK 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hs2st	NP_477339.1	Sulfotransfer_2	70..325	CDD:281554	153/255 (60%)
Hs2st1	NP_001342163.1	Sulfotransfer_2	76..327	CDD:308913	151/250 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833271
Domainoid	1	1.000	350	1.000	Domainoid score	I1017
eggNOG	1	0.900	-	-		E1_KOG3922
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8025
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2161
Isobase	1	0.950	-	0	Normalized mean entropy	S3013
OMA	1	1.010	-	-		QHG52295
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005800
OrthoInspector	1	1.000	-	-		oto94869
orthoMCL	1	0.900	-	-		OOG6_107368
Panther	1	1.100	-	-	LDO	PTHR12129
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2579
SonicParanoid	1	1.000	-	-		X4188
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740