Protein Alignment IKKbeta and IKBKE

DIOPT Version :9

• Sequence 1: NP_524751.3
• Gene: IKKbeta / 44432
• FlyBaseID: FBgn0024222
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_054721.1
• Gene: IKBKE / 9641
• HGNCID: 14552
• Length: 716
• Species: Homo sapiens
• Alignment Length: 812
• Identity: 191/812 - (23%)
• Similarity: 305/812 - (37%)
• Gaps: 207/812 - (25%)

  Fly     1 MHSFGN--WERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWS 63
            |.|..|  |.....||:|....|...||:.:|..:|.|.......| ..::|::
Human     1 MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYL-RPREVQV----------- 53

  Fly    64 RQFK-----NFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTE 123
            |:|:     |..:||....:|:..         .::..|:|:|||:.|.:...|:|||||.||.|
Human    54 REFEVLRKLNHQNIVKLFAVEETG---------GSRQKVLVMEYCSSGSLLSVLESPENAFGLPE 109

  Fly   124 FEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSV 188
            .|...:|..:...::.|... ||.|||:||.||:...|.:|:.||||||||.||...|.....||
Human   110 DEFLVVLRCVVAGMNHLREN-GIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSV 173

  Fly   189 VGTRHYYAPEVVENGF--------YNSTVDLWSFGVIAYELVTGELPFIPH---QTLKNIILNL- 241
            .||..|..|::.|...        :..||||||.||..|...||.|||||.   :..|.|:..:
Human   174 YGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRIT 238

  Fly   242 IKKPAKCIAITEDPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPV 306
            .:|||..||..:..| |......:.||.|..||....:|..     |:.:|..|..|........
Human   239 TEKPAGAIAGAQRRE-NGPLEWSYTLPITCQLSLGLQSQLV-----PILANILEVEQAKCWGFDQ 297

  Fly   307 VFADLDKILNMNVLTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTG--------MDEKELYFVL 363
            .||:...||...|:.:|:::........:.|..|:......:...|.        :.|..|..:.
Human   298 FFAETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCVLE 362

  Fly   364 PT-SHPHKTITPKSTPLQLYVE------EWSDTSKDSRKWTKRSNPPVMLYIFQVKKECDYKIPE 421
            |: |..|...|..|:||.|:..      .:.|.:.|..|           ::.:|..:.||...:
Human   363 PSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVPK-----------FVPKVDLQADYNTAK 416

  Fly   422 PILSI------LSRKFIANK---FKTKERWLQKRVVLDMLYVLTKEQARYEMLVSGINERALSLE 477
            .:|..      |:|..:..:   |:.. .|:.:  ||......|.|.||..:|.       ||
Human   417 GVLGAGYQALRLARALLDGQELMFRGL-HWVME--VLQATCRRTLEVARTSLLY-------LS-- 469

  Fly   478 DEMMENSFIDSIDKQRIIISFAYDQLTSLLKEAQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSI 542
                     .|:..:|........::..|...|:.:...|.|.     |.|:|....|.::.:|:
Human   470 ---------SSLGTERFSSVAGTPEIQELKAAAELRSRLRTLA-----EVLSRCSQNITETQESL 520

  Fly   543 RSFLEACLREAKDMVKTTNQLRKEVCEKDLFDCARFYKKYLCNGAIISPSELNNDAEEFAKSRFK 607
            .|.       .:::||:.:|:.::...:.:..|.               .::|...::|.|||.:
Human   521 SSL-------NRELVKSRDQVHEDRSIQQIQCCL---------------DKMNFIYKQFKKSRMR 563

  Fly   608 L---YNEGEARHLPKSIDHMHYLYFKTKESIPVLLQQF--------------------------- 642
            .   |||.:...|    |.:::.:...:     |||.|
Human   564 PGLGYNEEQIHKL----DKVNFSHLAKR-----LLQVFQEECVQKYQASLVTHGKRMRVVHETRN 619

  Fly   643 -----------CDIKKEIFQINLQMLM-------------SASSTPPP--------KLELSAAMD 675
                       |:.:.:..|.:|..|:             .|.::|||        :.:|...|.
Human   620 HLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQ 684

  Fly   676 RLAISSGSPSSDPFDSLRTINAIEEAERINNI 707
            .|.......:||..|:.|.|      ||:|.:
Human   685 ELCEGMKLLASDLLDNNRII------ERLNRV 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567	83/254 (33%)
		PKc_like	13..316	CDD:304357	102/319 (32%)
IKBKE	NP_054721.1	PKc_like	15..330	CDD:328722	106/342 (31%)
		UBL_TBK1_like	297..383	CDD:240618	19/85 (22%)
		Interaction with DDX3X	383..647		54/331 (16%)
		Leucine-zipper	436..457		4/23 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810