DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IKKbeta and Ikbkb

DIOPT Version :9

Sequence 1:	NP_524751.3	Gene:	IKKbeta / 44432	FlyBaseID:	FBgn0024222	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_445807.2	Gene:	Ikbkb / 84351	RGDID:	621375	Length:	757	Species:	Rattus norvegicus

Alignment Length:	683	Identity:	183/683 - (26%)
Similarity:	298/683 - (43%)	Gaps:	114/683 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GNWERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWSRQFKNF 69
            |.||....||.||||.||.|.|:.||.:||.|..::      :...|..:||..|:...|:. |.
  Rat    13 GAWEMKERLGTGGFGNVIRWHNQVTGEQIAIKQCRQ------ELSPKNRDRWCLEIQIMRRL-NH 70

  Fly    70 PHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGALR 134
            |::||..|:.     |.:..:....||::.:|||.|||:|:.|...||..||.|..:..:|..:.
  Rat    71 PNVVAARDVP-----EGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREGAILTLLSDIA 130

  Fly   135 KALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAPEV 199
            .||.:||.. .|.||||||:|||:|:| :.:.|:|:.|.|.|:.....::..|.|||..|.|||:
  Rat   131 SALRYLHEN-RIIHRDLKPENIVLQQG-EKRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 193

  Fly   200 VENGFYNSTVDLWSFGVIAYELVTGELPFIP-------HQTLKNIILNLIKKPAKCIAITEDPED 257
            :|...|..|||.||||.:|:|.:||..||:|       |..::       :|....|.::||...
  Rat   194 LEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVR-------QKSEVDIVVSEDLNG 251

  Fly   258 NTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERG---QLAANNVPVVFADLDKILNMNV 319
            ..:|.:  .||..::|:...|.:..|||...|....::||   |...|.   .|..||.|||:.:
  Rat   252 TVKFSS--SLPFPNNLNSVLAERLEKWLQLMLTWQPRQRGVDPQYGPNG---CFRALDDILNLKL 311

  Fly   320 LTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTGM--DEKEL-----YFVLPTSHPHKTITPKST 377
            :.|..:.......|.|..:.:::.|...|..|||:  .::||     ..:||.....:.|:...|
  Rat   312 VHILNMVTGTIHTYPVMEDESLQSLKTRIREDTGILETDQELLQEAGLVLLPDKPATQCISDSKT 376

  Fly   378 ----PLQLYVEEWSDTSKDS--RKWTKRSNPPVMLYIFQVKKECDYKIPEPILSILSRKFIANKF 436
                .|.:.:....|.||.|  .:.|.|..|..:        .|..:.|:..||.         |
  Rat   377 NEGLTLDMDLVFLFDNSKMSYETQITPRPQPESV--------SCVLQEPKRNLSF---------F 424

  Fly   437 KTKERWLQKRVVLDMLYVLTKEQARYEMLVSGINERALSLEDEMMENSFIDSIDKQRIIISFAYD 501
            :.::.|.|   |...:..|.::..|.:.     .:|| ::.:.:..||.:..:.          :
  Rat   425 QMRKVWGQ---VWHSIQTLKEDCNRLQQ-----GQRA-AMMNLLRNNSCLSKMK----------N 470

  Fly   502 QLTSLLKEAQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSF------LEACLRE--AKDMVK 558
            .:.|..::.:||:...:.......||......|.|.|.|.:.::      :|.|.||  .|.:|:
  Rat   471 AMASTAQQLKAKLDFFKTSIQIDLEKYREQTEFGITSDKLLLAWREMEQAVEQCGRENDVKVLVE 535

  Fly   559 TTNQLRKEVCEKDLFDCARFYKKYLCNGAIISPSELNNDAEEFAKSRFKLYNEGEARHLPKSIDH 623
                 |....:.|:.|..|........|.:       :|.||.|:..::...| :.|......|
  Rat   536 -----RMMALQTDIVDLQRSPMGRKQGGTL-------DDLEEQARELYRRLRE-KPRDQRTEGD- 586

  Fly   624 MHYLYFKTKESIPVLLQQFCDIKKEIFQINLQM 656
                   :::.:.:|||.....:|::..|..|:
  Rat   587 -------SQDMVRLLLQAIQSFEKKVRVIYSQL 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567	90/244 (37%)
IKKbeta	NP_524751.3	PKc_like	13..316	CDD:304357	109/312 (35%)
Ikbkb	NP_445807.2	STKc_IKK_beta	20..309	CDD:270940	110/314 (35%)
		Ubl_IKKA_like	310..390	CDD:340566	15/79 (19%)
		IKBKB_SDD	389..663	CDD:408196	54/281 (19%)
		Leucine-zipper	458..479		3/30 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..703
		IKKbetaNEMObind	708..742	CDD:403417
		NEMO-binding	737..742
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350235
Domainoid	1	1.000	159	1.000	Domainoid score	I3988
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013139at2759
OrthoFinder	1	1.000	-	-		FOG0003594
OrthoInspector	1	1.000	-	-		otm45925
orthoMCL	1	0.900	-	-		OOG6_105964
Panther	1	1.100	-	-	LDO	PTHR22969
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2467
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.710