DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IKKbeta and Ikbke

DIOPT Version :9

Sequence 1:	NP_524751.3	Gene:	IKKbeta / 44432	FlyBaseID:	FBgn0024222	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_062751.2	Gene:	Ikbke / 56489	MGIID:	1929612	Length:	717	Species:	Mus musculus

Alignment Length:	775	Identity:	182/775 - (23%)
Similarity:	299/775 - (38%)	Gaps:	143/775 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHSFGN--WERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWS 63
            |.|..|  |.....||:|....|...||:.:|..:|.|...                       |
Mouse     1 MQSTTNYLWHTDDLLGQGATASVYKARNKKSGEVVAVKVFN-----------------------S 42

  Fly    64 RQFKNFPHIVAGVDIEDPDFLEYLNGMFSAKL-----------PVIVLEYCNGGDVRKRLQSPEN 117
            ..::..|.    |.:.:.:.|..||.....||           .|:::|||:.|.:...|:.|||
Mouse    43 ASYRRPPE----VQVREFEVLRRLNHQNIVKLFAVEETGGSRQKVLIMEYCSSGSLLSVLEDPEN 103

  Fly   118 ANGLTEFEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQ 182
            ..||:|.|...:|..:...::.|... ||.|||:||.||:...|.:|:.||||:|||.||...|.
Mouse   104 TFGLSEEEFLVVLRCVVAGMNHLREN-GIVHRDIKPGNIMRLVGEEGQSIYKLSDFGAARKLDDD 167

  Fly   183 TMVQSVVGTRHYYAPEVVENGF--------YNSTVDLWSFGVIAYELVTGELPFIPH---QTLKN 236
            ....||.||..|..|::.|...        :..||||||.||..|...||.|||||.   :..|.
Mouse   168 EKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRNKE 232

  Fly   237 IILNL-IKKPAKCIAITEDPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLA 300
            |:..: .:|||..|:.|: .::|......:.||.|..||.....|..     |:.:|..|..:..
Mouse   233 IMYRITTEKPAGAISGTQ-KQENGPLEWSYSLPITCRLSMGLQNQLV-----PILANILEVEEDK 291

  Fly   301 ANNVPVVFADLDKILNMNVLTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTGMDEKELYFVLPT 365
            .......||:...||...|:.:|::.........:.|..|:...:..:...|.:..|...::. .
Mouse   292 CWGFDQFFAETSDILQRTVIHVFSLPQAVLHHVYIHAHNTIAIFLEAVYEQTNVTPKHQEYLF-E 355

  Fly   366 SHP----------HKTITPKSTPLQLYVEEWSDTSKDSRKWTKRSNP--PVMLYIFQVKKECDYK 418
            .||          |...|..|:||.|:     ..|.|:.|.....:|  .|..::.:|..:.||.
Mouse   356 GHPCVLEPSLSAQHIAHTAASSPLTLF-----SMSSDTPKGLAFRDPALDVPKFVPKVDLQADYS 415

  Fly   419 IPEPILSILSRKFIANKFKTKERWLQKRVVLD----ML----YVLTKEQARYEMLVSGINERALS 475
            ..:.:|..          ..:..|| .||:||    ||    :||...|...:..:.......|.
Mouse   416 TAKGVLGA----------GYQALWL-ARVLLDGQALMLRGLHWVLEVLQDTCQQTLEVTRTALLY 469

  Fly   476 LEDEMMENSFIDSID-------KQRIIISFAYDQLTSLLKEAQAKIPSRQLISSAQWEKLNRNYN 533
            |...:....|.....       |:...:......|:.:|.:....:...|...|...|:|.:|.:
Mouse   470 LSSSLGTERFSSGAGMPDVQERKEATELRTRLQTLSEILSKCSHNVTETQRSLSCLGEELLKNRD 534

  Fly   534 FIIQSAKSIRSFLEACLREAKDMVKTTNQLRKEVCEKDL-FDCARFYKKYLCNGAIISPSELNND 597
            .|.:..|||:. ::.||.:...:.|   |.:|......| ::..:.:|....|.:.::...|...
Mouse   535 QIHEDNKSIQK-IQCCLDKMHFIYK---QFKKSRMRPGLSYNEEQIHKLDKVNFSHLAKRLLQVF 595

  Fly   598 AEEFAKS-RFKLYNEGE-ARHLPKSIDHMHYLYFKTKESIPVLLQQFCDIKKEIFQINLQMLMSA 660
            .||..:: :..|...|: .|.:.::.:|:|.:    ..|:.....:....::.:.:|..|:|:..
Mouse   596 QEECVQTYQVSLVTHGKRMRQVQRAQNHLHLI----GHSVATCNSEARGAQESLNKIFDQLLLDR 656

  Fly   661 SS------TPPPKLELSAAMDRLAISSGSPSSDPFDSLRTINAIEEAERINNILVNEMKI 714
            :|      :|.|             .:..|..||.|   .:..::|       |.|:||:
Mouse   657 ASEQGAEVSPQP-------------MAPHPGPDPKD---LVFHMQE-------LCNDMKL 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567	79/260 (30%)
IKKbeta	NP_524751.3	PKc_like	13..316	CDD:304357	96/325 (30%)
Ikbke	NP_062751.2	PKc_like	15..330	CDD:389743	100/348 (29%)
		Ubl_IKKE	308..383	CDD:340648	14/80 (18%)
		Interaction with DDX3X. /evidence=ECO:0000250	385..650		53/283 (19%)
		TBK1_CCD1	402..648	CDD:375820	47/264 (18%)
		Leucine-zipper	452..473		3/20 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810