DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IKKbeta and Tbk1

DIOPT Version :9

Sequence 1:	NP_524751.3	Gene:	IKKbeta / 44432	FlyBaseID:	FBgn0024222	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_062760.3	Gene:	Tbk1 / 56480	MGIID:	1929658	Length:	729	Species:	Mus musculus

Alignment Length:	798	Identity:	184/798 - (23%)
Similarity:	295/798 - (36%)	Gaps:	228/798 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHSFGN--WERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGAL-SADQQVKLSERWNKELNW 62
            |.|..|  |.....||:|....|...|::.||...|.|....:..| ..|.|::..|.. |:||
Mouse     1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVL-KKLN- 63

  Fly    63 SRQFKNFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFE-- 125
               .||...:.|   ||:..         :.:..|:::|:|..|.:...|:.|.||.||.|.|
Mouse    64 ---HKNIVKLFA---IEEET---------TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 113

  Fly   126 --VRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSV 188
              :|.::|.:.   |...:  ||.|||:||.||:...|.||:.:|||||||.||...|.....|:
Mouse   114 IVLRDVVGGMN---HLREN--GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL 173

  Fly   189 VGTRHYYAPEVVENGF--------YNSTVDLWSFGVIAYELVTGELPFIPHQ---TLKNIILNLI 242
            .||..|..|::.|...        |.:||||||.||..|...||.|||.|.:   ..|.::..:|
Mouse   174 YGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238

  Fly   243 K-KPAKCIAITEDPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPV 306
            . ||:..|:..:..| |.......::|.:..||:...|     |.:|:.:|..|..|........
Mouse   239 TGKPSGAISGVQKAE-NGPIDWSGDMPLSCSLSQGLQA-----LLTPVLANILEADQEKCWGFDQ 297

  Fly   307 VFADLDKILNMNVLTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTGMDEKELYFVLPTSHPHKT 371
            .||:...:|:..|:.:|::.:.                                    |:|
Mouse   298 FFAETSDVLHRMVIHVFSLQHM------------------------------------TAH---- 322

  Fly   372 ITPKSTPLQLYVEEWSDTSKDSR---KWTKRSNPPVMLYIFQVKKECDYKIPEPILSILSRKFIA 433
                    ::|:..::..:....   |.||         |....:|..|:....:|. |.|  :|
Mouse   323 --------KIYIHSYNTAAVFHELVYKQTK---------IVSSNQELIYEGRRLVLE-LGR--LA 367

  Fly   434 NKF-KTKERWLQKRVVLDMLYVLTKEQ-----ARYEML-VSGINERALSLEDEMMENSFIDSIDK 491
            ..| ||.|.        :.::|.::||     .|||.: :..|:.|.....|..|..:...
Mouse   368 QHFPKTTEE--------NPIFVTSREQLNTVGLRYEKISLPKIHPRYDLDGDASMAKAVTG---- 420

  Fly   492 QRIIISFAYDQLTSLL--KEAQAKIPSRQLISSAQW--EKLNRNYNFIIQSAKSIRSFLEACLRE 552
               ::.:|....::||  :|...|        ..:|  |.:..:||..:.....:...|:.|:|.
Mouse   421 ---VVCYACRTASTLLLYQELMRK--------GVRWLVELVKDDYNETVHKKTEVVITLDFCIRN 474

  Fly   553 AKDMVKTTNQLRKEVCE-KDLFDCARFYKKYL----CNGAI----------ISPSELNNDA---- 598
            .:..||...:|.|...| .:|.:.:..:.|.|    ..|.|          :||..|..|.
Mouse   475 IEKTVKVYEKLMKVNLEAAELGEISDIHTKLLRLSSSQGTIESSLQDISSRLSPGGLLADTWAHQ 539

  Fly   599 ------------------------EEFAKSRFK---LYNEGEAR---------HLPKSIDHM--- 624
                                    .:|.|.:.:   .|||.:..         |..|::.|.
Mouse   540 EGTHPRDRNVEKLQVLLNCITEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMSHFSEE 604

  Fly   625 ---HYLYFKTK------------ESIPVLLQQFCDIKKEI-----FQINLQMLMSASSTPPPKLE 669
               .|..||.|            :.:..|..|..||::|:     :...||      .|.|.|:.
Mouse   605 CVRKYEAFKDKSEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDYTNELQ------ETLPQKML 663

  Fly   670 LSAAMDRLAISSGSPSSD 687
            .::...:.|::...|||:
Mouse   664 AASGGVKHAMAPIYPSSN 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567	83/254 (33%)
IKKbeta	NP_524751.3	PKc_like	13..316	CDD:304357	98/319 (31%)
Tbk1	NP_062760.3	S_TKc	9..242	CDD:214567	83/254 (33%)
		STKc_TBK1	15..330	CDD:270890	104/390 (27%)
		UBL_TBK1_like	297..385	CDD:240618	23/155 (15%)
		Interaction with AZI2, TANK and TBKBP1. /evidence=ECO:0000250\|UniProtKB:Q9UHD2	621..729		14/67 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810