DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IKKbeta and ikbkb

DIOPT Version :9

Sequence 1:	NP_524751.3	Gene:	IKKbeta / 44432	FlyBaseID:	FBgn0024222	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001116737.1	Gene:	ikbkb / 563560	ZFINID:	ZDB-GENE-071115-2	Length:	779	Species:	Danio rerio

Alignment Length:	817	Identity:	195/817 - (23%)
Similarity:	339/817 - (41%)	Gaps:	194/817 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GNWERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWSRQFKNF 69
            |.||....||.||||.|..|:|:.|..:||.|..::      :..||...||:.|:...::..:.
Zfish    13 GPWELKERLGTGGFGNVTLWQNKETSIQIAIKQCRQ------ELSVKNKGRWSLEIQIMKRLTHM 71

  Fly    70 PHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGALR 134
             ::||..|:.     |.|..:.:..||::.:|:|.|||:||.|...||..|:.|..|..::..:.
Zfish    72 -NVVAARDVP-----EELQKLATNDLPLLAMEFCQGGDLRKYLNLVENCCGMREAAVLTLIQDIS 130

  Fly   135 KALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAPEV 199
            .||.:||.. .|.||||||:|||:|:| :.:.::|:.|.|.|:.....::..|.|||..|.|||:
Zfish   131 SALTYLHGM-RIIHRDLKPENIVLQQG-EKRLVHKIIDLGYAKELDQSSLCTSFVGTLQYLAPEL 193

  Fly   200 VENGFYNSTVDLWSFGVIAYELVTGELPFIP-------HQTLKNIILNLIKKPAKCIAITEDPED 257
            :|...|...||.||||.:.:|.:||..||:|       |..|:       :|....|.:.||...
Zfish   194 LEQQKYTVAVDYWSFGTLVFECITGFRPFLPTWQPVQWHSKLQ-------QKHVDDIVVYEDLGG 251

  Fly   258 NTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQ------------------------ 298
            ..|:..  .||..|:|::..|.:..:||...|..:.||||:
Zfish   252 EVRYSK--HLPNPHNLNKLLAGELERWLQMMLRWSPKERGKDLKQRNKESQETPKDAEEESKETS 314

  Fly   299 -LAANNVP----VVFADLDKILNMNVLTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTGMDEKE 358
             ..|.:.|    ..|.:|..|||:.::.:..:.:.|...|:|..|..:..|...|..|||:....
Zfish   315 PEGAKDAPKAPCFCFDELSHILNLKLVHVLNMTSAEIFNYSVQPEDDVASLQERIAQDTGIPPAN 379

  Fly   359 LYFVLPTSHPHKTITPKSTPLQLYVEEWSDTSKDSRKWTKRSNPPVMLYIFQVKKECDYK----- 418
            ...:|...   ..:.|:::.:|..::.   :..|:|    |::.| ::::|. :..|.|:
Zfish   380 QELLLEAG---LALEPQNSVMQCAIDY---SLMDNR----RADEP-LVFLFD-RSCCSYEPQFTP 432

  Fly   419 --IPEPILSILSRKFIANKFK---------------------TKERWL-----QKRVVLDMLY-- 453
              :||.|      :|:.|:.|                     .||.|.     ||..::.:|.
Zfish   433 RVLPENI------RFVQNEPKRPLPYSSQRRTWGQAWHTIRALKEDWQRLQQGQKVAIMSLLRHN 491

  Fly   454 -VLTKEQARYEMLVSGINERALSLEDEMMENSFID--SIDKQRIIISFAYDQLTSLLKE-AQAKI 514
             .|:|:  :.||:  .:::|..:..|....:..:|  ...:|| ....|.::|.|:.:| .|..:
Zfish   492 GTLSKQ--KNEMV--SMHQRLKATLDFFGASLHVDISKYQEQR-ATGIASEKLLSVWREMEQTAL 551

  Fly   515 PSRQL--ISSAQWEKLNRNYNFIIQSAKSIRS--FLEACLREAKDMVKTTNQLRKEVCEKDLFDC 575
            ...|.  :...:.|.:....:.:....:..||  .||....:|.::.:...:..:|  ::.:.||
Zfish   552 DCGQTEDVFKLEEEMMTLQTDIVDLQRQPWRSGEALETLEVKAMELFRKLREKPRE--QRSMGDC 614

  Fly   576 ----------ARFYKKYL------------CNGAIIS--PSELNNDAEEFAKSRFKLYNEGEARH 616
                      .:||::.|            |...:::  |..                 ||....
Zfish   615 QEVIKLVVQAVQFYERKLRDFYTHLSKTMVCRQRVLALLPRV-----------------EGLVSA 662

  Fly   617 LPKSIDHMHYLYFKTKESIPVLLQQFCDIKKEIFQINLQMLMSAS----STPP---PKLELSAAM 674
            :.:|...:.:|..|.::.:..||:..|.        .::..:|.|    .|||   |:|
Zfish   663 MARSEKQLLHLQEKRQKELWNLLKVACS--------KVRSPVSGSPDGGRTPPAPTPQL------ 713

  Fly   675 DRLAISSGSPSSDPFDSLRT---INAIEEAERINNIL 708
              ::.....|||.|.|...|   ::.|||:....|.|
Zfish   714 --MSHRPSHPSSPPSDGPHTEESLHVIEESRIFENRL 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567	84/244 (34%)
IKKbeta	NP_524751.3	PKc_like	13..316	CDD:304357	104/338 (31%)
ikbkb	NP_001116737.1	STKc_IKK_beta	20..338	CDD:270940	105/340 (31%)
ikbkb	NP_001116737.1	TGS	329..>380	CDD:330245	14/50 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591911
Domainoid	1	1.000	147	1.000	Domainoid score	I4458
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013139at2759
OrthoFinder	1	1.000	-	-		FOG0003594
OrthoInspector	1	1.000	-	-		otm26380
orthoMCL	1	0.900	-	-		OOG6_105964
Panther	1	1.100	-	-	LDO	PTHR22969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6738
SonicParanoid	1	1.000	-	-		X2467
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.740