Protein Alignment IKKbeta and ikbkb

DIOPT Version :10

• Sequence 1: NP_524751.3
• Gene: IKKbeta / 44432
• FlyBaseID: FBgn0024222
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: XP_017947506.1
• Gene: ikbkb / 448125
• XenbaseID: XB-GENE-949877
• Length: 769
• Species: Xenopus tropicalis
• Alignment Length: 693
• Identity: 183/693 - (26%)
• Similarity: 312/693 - (45%)
• Gaps: 105/693 - (15%)

  Fly     5 GNWERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWSRQFKNF 69
            |.||....||.||||.|:.|.::.||.::|.|..::      :...|..|||..|:...::. |.
 Frog    24 GPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQ------ELSPKNRERWCLEIQIMKKL-NH 81

  Fly    70 PHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGALR 134
            |::|:..::  ||.|:.|   ....||::.:|||.|||:||.|...||..||.|..:..:|..:.
 Frog    82 PNVVSAREV--PDGLQKL---APNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPILTLLSDIS 141

  Fly   135 KALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAPEV 199
            .||.:||.. .|.||||||:|||:|.|.. :.|:|:.|.|.|:.....::..|.|||..|.|||:
 Frog   142 SALRYLHEN-RIIHRDLKPENIVLQPGPQ-RLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 204

  Fly   200 VENGFYNSTVDLWSFGVIAYELVTGELPFIP-------HQTLKNIILNLIKKPAKCIAITEDPED 257
            :|...|..|||.||||.:|:|.:||..||:|       |..::       :|..:.|.:.||...
 Frog   205 LEQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVR-------EKSNEHIVVYEDLMG 262

  Fly   258 NTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPVVFADLDKILNMNVLTI 322
            ..:|.:  .||..:||:...|.:...||...|..:.::||....|.....|..||.||::.:|::
 Frog   263 AVKFSS--VLPTPNHLNSKLAGKLEHWLQCMLMWHQRQRGTDPQNPNVGCFQALDSILSLKLLSV 325

  Fly   323 FAVNNCERLEYAVSAEMTMKDLIALIVLDTGMDEKELYFVLPTSHPHKTITPKSTPLQLYVEEWS 387
            ..:.:.:...|.||....:::|.:.:..|||:.|:|...:..:.   ..:.| :.||..:|.:.
 Frog   326 LNMVSGKVHTYPVSENENLQNLKSRLEQDTGIPEEEQELLQASG---LALNP-AQPLTQFVVDC- 385

  Fly   388 DTSKDSRKWTKRSNPPVMLYIFQVKKECDYKIPEPILSILSR-KFIANKFKTKERWLQ----KRV 447
             |..|.|:     ....::::|..:|    .:.||.:|:.:. :.:....:..:|.|.    :||
 Frog   386 -TVNDGRQ-----GEGDLIFLFDNRK----TVYEPQISLPAHPESVTVILQDPKRPLTYTHLRRV 440

  Fly   448 ---VLDMLYVLTKEQARYEMLVSGINERALSLEDEMMENSFIDSIDKQRIIISFAYDQLTSLLKE 509
               ....:..:.::.||   |:.|             :.:|:.::.:....:|...:.:||..::
 Frog   441 WGQTWQTIRAMKEDCAR---LLHG-------------QRTFMVNLLRYNTELSKKKNLMTSEFEQ 489

  Fly   510 AQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSF------LEACLREAKDMVKTTNQLRKEVC 568
            .:||:...:.......||.:....|.|.|.|.:.::      :|.|.||.:........:   ..
 Frog   490 LKAKLDFFRNSIQIDLEKYSEQMEFGITSEKLLSAWRETEQTVELCGREREVQALVDKMM---AL 551

  Fly   569 EKDLFDCAR--FYKKYLCNGAIISPSELNNDAEEFAKSRFKLYNEGEARHLPKSIDHMHYLYFKT 631
            :.|..|..|  ..:|:  .|.:       :|.||.||..::...| ..|....:.|        :
 Frog   552 QTDSVDLQRNPLGRKH--RGTL-------DDLEEQAKDLYRRLRE-RPRDQRTAGD--------S 598

  Fly   632 KESIPVLLQQFCDIKKEIFQINLQMLMSASSTPPPK---LELS 671
            .|.:.:|:|.....:|.:..|..|:    |.|...|   ||||
 Frog   599 NEMVRLLIQAIQSFEKRVILIYDQL----SKTVACKHKALELS 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	Protein Kinases, catalytic domain	13..316	CDD:473864	107/309 (35%)
ikbkb	XP_017947506.1	STKc_IKK_beta	31..320	CDD:270940	108/311 (35%)
		Ubl_IKKA_like	321..401	CDD:340566	17/90 (19%)
		IKBKB_SDD	400..674	CDD:465745	55/283 (19%)
		IKKbetaNEMObind	718..754	CDD:463485