DRSC/TRiP Functional Genomics Resources

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Protein Alignment IKKbeta and ikbkb

DIOPT Version :9

Sequence 1:NP_524751.3 Gene:IKKbeta / 44432 FlyBaseID:FBgn0024222 Length:717 Species:Drosophila melanogaster
Sequence 2:XP_017947506.1 Gene:ikbkb / 448125 XenbaseID:XB-GENE-949877 Length:769 Species:Xenopus tropicalis


Alignment Length:693 Identity:183/693 - (26%)
Similarity:312/693 - (45%) Gaps:105/693 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 GNWERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWSRQFKNF 69
            |.||....||.||||.|:.|.::.||.::|.|..::      :...|..|||..|:...::. |.
 Frog    24 GPWEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQ------ELSPKNRERWCLEIQIMKKL-NH 81

  Fly    70 PHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGALR 134
            |::|:..::  ||.|:.|   ....||::.:|||.|||:||.|...||..||.|..:..:|..:.
 Frog    82 PNVVSAREV--PDGLQKL---APNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPILTLLSDIS 141

  Fly   135 KALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAPEV 199
            .||.:||.. .|.||||||:|||:|.|.. :.|:|:.|.|.|:.....::..|.|||..|.|||:
 Frog   142 SALRYLHEN-RIIHRDLKPENIVLQPGPQ-RLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 204

  Fly   200 VENGFYNSTVDLWSFGVIAYELVTGELPFIP-------HQTLKNIILNLIKKPAKCIAITEDPED 257
            :|...|..|||.||||.:|:|.:||..||:|       |..::       :|..:.|.:.||...
 Frog   205 LEQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVR-------EKSNEHIVVYEDLMG 262

  Fly   258 NTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPVVFADLDKILNMNVLTI 322
            ..:|.:  .||..:||:...|.:...||...|..:.::||....|.....|..||.||::.:|::
 Frog   263 AVKFSS--VLPTPNHLNSKLAGKLEHWLQCMLMWHQRQRGTDPQNPNVGCFQALDSILSLKLLSV 325

  Fly   323 FAVNNCERLEYAVSAEMTMKDLIALIVLDTGMDEKELYFVLPTSHPHKTITPKSTPLQLYVEEWS 387
            ..:.:.:...|.||....:::|.:.:..|||:.|:|...:..:.   ..:.| :.||..:|.:. 
 Frog   326 LNMVSGKVHTYPVSENENLQNLKSRLEQDTGIPEEEQELLQASG---LALNP-AQPLTQFVVDC- 385

  Fly   388 DTSKDSRKWTKRSNPPVMLYIFQVKKECDYKIPEPILSILSR-KFIANKFKTKERWLQ----KRV 447
             |..|.|:     ....::::|..:|    .:.||.:|:.:. :.:....:..:|.|.    :||
 Frog   386 -TVNDGRQ-----GEGDLIFLFDNRK----TVYEPQISLPAHPESVTVILQDPKRPLTYTHLRRV 440

  Fly   448 ---VLDMLYVLTKEQARYEMLVSGINERALSLEDEMMENSFIDSIDKQRIIISFAYDQLTSLLKE 509
               ....:..:.::.||   |:.|             :.:|:.::.:....:|...:.:||..::
 Frog   441 WGQTWQTIRAMKEDCAR---LLHG-------------QRTFMVNLLRYNTELSKKKNLMTSEFEQ 489

  Fly   510 AQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSF------LEACLREAKDMVKTTNQLRKEVC 568
            .:||:...:.......||.:....|.|.|.|.:.::      :|.|.||.:........:   ..
 Frog   490 LKAKLDFFRNSIQIDLEKYSEQMEFGITSEKLLSAWRETEQTVELCGREREVQALVDKMM---AL 551

  Fly   569 EKDLFDCAR--FYKKYLCNGAIISPSELNNDAEEFAKSRFKLYNEGEARHLPKSIDHMHYLYFKT 631
            :.|..|..|  ..:|:  .|.:       :|.||.||..::...| ..|....:.|        :
 Frog   552 QTDSVDLQRNPLGRKH--RGTL-------DDLEEQAKDLYRRLRE-RPRDQRTAGD--------S 598

  Fly   632 KESIPVLLQQFCDIKKEIFQINLQMLMSASSTPPPK---LELS 671
            .|.:.:|:|.....:|.:..|..|:    |.|...|   ||||
 Frog   599 NEMVRLLIQAIQSFEKRVILIYDQL----SKTVACKHKALELS 637

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IKKbetaNP_524751.3 S_TKc 7..245 CDD:214567 89/244 (36%)
PKc_like 13..316 CDD:304357 107/309 (35%)
ikbkbXP_017947506.1 STKc_IKK_beta 31..320 CDD:270940 108/311 (35%)
Ubl_IKKA_like 321..401 CDD:340566 17/90 (19%)
IKBKB_SDD 400..674 CDD:375823 55/283 (19%)
IKKbetaNEMObind 720..754 CDD:371944
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 152 1.000 Domainoid score I4282
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1013139at2759
OrthoFinder 1 1.000 - - FOG0003594
OrthoInspector 1 1.000 - - otm49011
Panther 1 1.100 - - LDO PTHR22969
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6738
SonicParanoid 1 1.000 - - X2467
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
88.050

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