DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IKKbeta and ikbke

DIOPT Version :9

Sequence 1:	NP_524751.3	Gene:	IKKbeta / 44432	FlyBaseID:	FBgn0024222	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001002751.1	Gene:	ikbke / 437024	ZFINID:	ZDB-GENE-040718-251	Length:	721	Species:	Danio rerio

Alignment Length:	679	Identity:	156/679 - (22%)
Similarity:	261/679 - (38%)	Gaps:	150/679 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHSFGN--WERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWS 63
            |.|..|  |.:...||:|....|...||:.||..:|   :|....:|.::..::..|..:.|
Zfish     1 MTSTANYLWSQEDILGQGATANVYKARNKKTGELVA---VKVFNLVSYNRPYEVQMREFEVL--- 59

  Fly    64 RQFKNFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQ 128
             |..|..:||....:|:.        :.:.|..::|:|||:||.:...|:.||:|.||.|.|...
Zfish    60 -QLLNHVNIVKLFAVEEI--------ISNPKQKILVMEYCSGGSLLNMLEQPEHAFGLPESEFLI 115

  Fly   129 ILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRH 193
            :|..:...::.|... .:.|||:||.||:.|.|.||:.:|||.|||.||...|.....|:.||..
Zfish   116 VLHCVAHGMNHLREN-SVVHRDIKPGNIMRQVGEDGRSVYKLADFGAARELEDDEKFVSIYGTEE 179

  Fly   194 YYAPEVVENGF--------YNSTVDLWSFGVIAYELVTGELPFIP-------HQTLKNIILNLIK 243
            |..|::.|...        |..:|||||.||..|.:.||.|||.|       .|.:..|   ..:
Zfish   180 YLHPDMYERAVLRSPQQKAYGVSVDLWSIGVTIYHMATGSLPFRPFGGPRKNKQMMHKI---TTE 241

  Fly   244 KPAKCIAITEDPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPVVF 308
            |||..||..:..||.. ...:.:||.:..||.....|....||:.|.::.::..:.     |..|
Zfish   242 KPAGTIAGVQKEEDGP-IEWRDKLPLSCQLSEGLKTQLVPVLANILLADDEKCWKF-----PQFF 300

  Fly   309 ADLDKILNMNVLTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTGMDEKELYFVLPTSHPHKTIT 373
            :..:.|||...:.||::.........:....|:......:...||::.....::. ..|| ..:.
Zfish   301 SATNDILNRITIYIFSLQQATTYSIYIQFHNTVSIFFEDVQAQTGIEPAAQQYLF-QGHP-LILD 363

  Fly   374 PKSTPLQLYVEEWSDTSKDSRKWTKRSNPPVMLYIFQVKKECDYKIPEP---------------- 422
            |     .:.|.....||.|.         |::|...::::...|...||
Zfish   364 P-----SMKVVNIPHTSSDK---------PMILISRRLERIIGYPFEEPESPPMPGKFDVVADFV 414

  Fly   423 ----ILSILS------------RKFIANKFKTKERWLQKRVVLDMLYVLTKEQARYEMLVS---- 467
                |:.::.            |:||...|.:........|: |:.:.::|.:.:....:|
Zfish   415 FTKTIVKVIHQYLRIAYSLQEYRQFILQGFNSYIEQTSSEVI-DVAHRISKVKMKLHSSISTEKT 478

  Fly   468 -----------------------------------GINE---------RALSLEDEMMENSFIDS 488
                                               ||.|         ..||...|.:.|.  .|
Zfish   479 LHVFTQTFAHEFPDFIDSKKKFPLIEAELQHMCGRGIREFQNILQYLRVTLSKHSETLAND--KS 541

  Fly   489 IDKQRIIISFAYDQLTSLLKEAQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSFLEACLREA 553
            |.|..:::|...|......::.|.:..........::|||  |.:..::..||:  |.:.|.::.
Zfish   542 IQKMEVLLSQIVDVHFQYFRDRQTRKLGYNDEQIHKFEKL--NLSSYLKKFKSL--FKDDCFQKY 602

  Fly   554 KDMVKTTNQLRKEVCEKDLFDCARFYKKY 582
            .|::.||::     |.:.|:|......|:
Zfish   603 LDVLNTTDR-----CSRALYDMQTHLDKF 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567	79/252 (31%)
IKKbeta	NP_524751.3	PKc_like	13..316	CDD:304357	96/317 (30%)
ikbke	NP_001002751.1	S_TKc	9..243	CDD:214567	79/252 (31%)
		PKc_like	15..327	CDD:304357	100/336 (30%)
		UBQ	298..386	CDD:294102	18/103 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810