DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IKKbeta and chuk

DIOPT Version :9

Sequence 1:	NP_524751.3	Gene:	IKKbeta / 44432	FlyBaseID:	FBgn0024222	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_956611.1	Gene:	chuk / 393287	ZFINID:	ZDB-GENE-040426-1069	Length:	758	Species:	Danio rerio

Alignment Length:	773	Identity:	188/773 - (24%)
Similarity:	311/773 - (40%)	Gaps:	178/773 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GNWERCRNLGEGGFGLVIHWRNRTTGREIATKHIK-EMGALSADQQVKLSERWNKELNWSRQFKN 68
            |:|.....||.||||.|..::|:.|..:||.|..: |:.:       |..:||::|:...::.|:
Zfish    13 GSWVMKERLGTGGFGHVYLYQNQETSEKIAVKLCRLELNS-------KNKDRWSREIQIMKKLKH 70

  Fly    69 FPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGAL 133
            . ::|...|:.:......||     .||::.:|||:.||:||.|..|||..||.|.||..:|..:
Zfish    71 L-NVVTAKDVPEEMMHIALN-----DLPLLAMEYCSKGDLRKLLSKPENCCGLKESEVLSLLNDV 129

  Fly   134 RKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAPE 198
            ...:.:||.. .|.||||||:|||:|. ::||.::|:.|.|.|:.....::..|.|||..|.|||
Zfish   130 GSGIQYLHEN-KIIHRDLKPENIVLQE-INGKLVHKIIDLGYAKDLDQGSLCTSFVGTLQYLAPE 192

  Fly   199 VVENGFYNSTVDLWSFGVIAYELVTGELPFIPHQTLKNIILNLIKKPAKCIAITEDPEDNTRFVN 263
            :.|...|..|||.||||.:.:|...|..||:.:.........:..|..|.|...||.....||
Zfish   193 LFEGKSYTVTVDFWSFGTMIFECCCGFRPFLHNLQPVQWTSKVRNKGPKDIMAVEDMNGEVRF-- 255

  Fly   264 QFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAAN---NVPVVFADLDKILNMNVLTIFAV 325
            ...||..::|||.........|...|..:..:|| |..|   ..|..|..||:||:|.|:.|..:
Zfish   256 STHLPYPNNLSRTLLEPLEGLLQLMLKWDPVQRG-LGLNTDSKQPQCFVLLDQILSMKVVHILNM 319

  Fly   326 NNC-----------------ERLEYAVSAEMTMKDLI-------------ALIVLD--TGMDEKE 358
            ...                 :|:|.....|:..:||:             |..|||  .|.|...
Zfish   320 TTTQVHSFLLSPDEGLHSLQQRIENETKIELLNQDLLQETGVMLDPRKPAAQCVLDGVRGWDSYI 384

  Fly   359 LYF---------------VLPTS-----HPHKTITPKSTPLQL------YV----EEWSDTSKDS 393
            :|.               .||.|     ...||..|.||..::      |:    |::|...:..
Zfish   385 VYLFDKSLTKYMGPLTARTLPESVNFIVRETKTQLPLSTLKKVWGEAVSYICGPREDYSRLFQGQ 449

  Fly   394 R-----------KWTKRSNPPVMLYIF--QVKKECDYKIPEPILSILSRKFIANKFKTKERWLQK 445
            |           ..|:..|   |::.|  |:|.:.|:                  |||..::..:
Zfish   450 RAAMLSLLRFNTNLTRYKN---MMFSFSQQLKAKLDF------------------FKTSIQYDLE 493

  Fly   446 RVVLDMLYVLTKEQ------------ARYEML--VSGINERALSLEDEMMENSFIDSIDKQRIII 496
            :....|.|.::.|:            |.:..:  :..::|..::|..|::|........:|..::
Zfish   494 KYSDQMQYGISSEKMLKAWHENEERAAAFAQVAEIGHLDEEIMALHSEIVELQRSPYARRQGDVM 558

  Fly   497 SFAYDQLTSLLKE--AQAKIPSRQ------------LISSAQ------------WEKLNRNYNFI 535
            ....::...|.|:  |:.|:|..|            ::.:.|            ..|:..:...|
Zfish   559 EQLQEKAIELYKQLKAKCKMPDPQHGYSDSSEMVKVIVQTVQNQDRVLRDLYAHLSKIPLSKQKI 623

  Fly   536 IQSAKSIRSFLEACLREAKDMVKTTNQLRKEVCEKDLFD-----CARFYKKYLCNGAIISPSELN 595
            |.....|...|| |::|| |......|:::   :::.:.     ||:...:...:.:...||.|:
Zfish   624 IDLFPKIERTLE-CIKEA-DTTVMQMQIKR---QREFWHLLKIACAQNTTRSSVSQSGEMPSSLS 683

  Fly   596 NDAEEFAKSRFKLYNEGEARHLPKSIDHM-----HYLYFKTKESIPVLLQQFCDIKKE 648
            ...:..|:...:|....:..|...|::|:     .||     ..:..|||:..:.|.|
Zfish   684 TWNQTQAQCSSRLPMSLQVPHEGDSVNHLLEENQRYL-----TQLTSLLQETTEEKSE 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567	82/238 (34%)
IKKbeta	NP_524751.3	PKc_like	13..316	CDD:304357	104/306 (34%)
chuk	NP_956611.1	S_TKc	15..288	CDD:214567	96/289 (33%)
		PKc_like	21..310	CDD:304357	104/306 (34%)
		Leucine-zipper	456..477		4/23 (17%)
		IKKbetaNEMObind	712..746	CDD:288990	7/30 (23%)
		NEMO-binding. /evidence=ECO:0000250	741..746
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591910
Domainoid	1	1.000	147	1.000	Domainoid score	I4458
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013139at2759
OrthoFinder	1	1.000	-	-		FOG0003594
OrthoInspector	1	1.000	-	-		otm26380
orthoMCL	1	0.900	-	-		OOG6_105964
Panther	1	1.100	-	-	O	PTHR22969
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2467
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.710