DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IKKbeta and IKBKB

DIOPT Version :9

Sequence 1:	NP_524751.3	Gene:	IKKbeta / 44432	FlyBaseID:	FBgn0024222	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_005273547.1	Gene:	IKBKB / 3551	HGNCID:	5960	Length:	805	Species:	Homo sapiens

Alignment Length:	677	Identity:	176/677 - (25%)
Similarity:	301/677 - (44%)	Gaps:	102/677 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GNWERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWSRQFKNF 69
            |.||....||.||||.||.|.|:.||.:||.|..::      :...:..|||..|:...|:..:
Human    13 GAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQ------ELSPRNRERWCLEIQIMRRLTH- 70

  Fly    70 PHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGALR 134
            |::||..|:.     |.:..:....||::.:|||.|||:||.|...||..||.|..:..:|..:.
Human    71 PNVVAARDVP-----EGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIA 130

  Fly   135 KALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAPEV 199
            .||.:||.. .|.||||||:|||:|:| :.:.|:|:.|.|.|:.....::..|.|||..|.|||:
Human   131 SALRYLHEN-RIIHRDLKPENIVLQQG-EQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 193

  Fly   200 VENGFYNSTVDLWSFGVIAYELVTGELPFIP-------HQTLKNIILNLIKKPAKCIAITEDPED 257
            :|...|..|||.||||.:|:|.:||..||:|       |..::       :|....|.::||...
Human   194 LEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVR-------QKSEVDIVVSEDLNG 251

  Fly   258 NTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPVVFADLDKILNMNVLTI 322
            ..:|.:  .||..::|:...|.:..|||...|..:.::||..........|..||.|||:.::.|
Human   252 TVKFSS--SLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCFKALDDILNLKLVHI 314

  Fly   323 FAVNNCERLEYAVSAEMTMKDLIALIVLDTGMDEKELYF-------VLPTSHPHKTITP----KS 376
            ..:.......|.|:.:.:::.|.|.|..|||:.|::...       ::|.....:.|:.    :.
Human   315 LNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEG 379

  Fly   377 TPLQLYVEEWSDTSKDSRKWTKRSNPPVMLYIFQVKKECDYKIPEPILSILS--RKFIANKFKTK 439
            ..|.:.:....|.||             :.|..|:.....   ||.:..||.  ::.:| .|:.:
Human   380 HTLDMDLVFLFDNSK-------------ITYETQISPRPQ---PESVSCILQEPKRNLA-FFQLR 427

  Fly   440 ERWLQKRVVLDMLYVLTKEQARYEMLVSGINERALSLEDEMMENSFIDSIDKQRIIISFAYDQLT 504
            :.|.|   |...:..|.::..|.:.     .:|| ::.:.:..||.:..:.          :.:.
Human   428 KVWGQ---VWHSIQTLKEDCNRLQQ-----GQRA-AMMNLLRNNSCLSKMK----------NSMA 473

  Fly   505 SLLKEAQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSFLEACLREAKDMVKTTNQL-----R 564
            |:.::.:||:...:.......||.:....|.|.|.|.:.::.|  :.:|.::....|::     |
Human   474 SMSQQLKAKLDFFKTSIQIDLEKYSEQTEFGITSDKLLLAWRE--MEQAVELCGRENEVKLLVER 536

  Fly   565 KEVCEKDLFDCARFYKKYLCNGAIISPSELNNDAEEFAKSRFKLYNEGEARHLPKSIDHMHYLYF 629
            ....:.|:.|..|........|.:       :|.||.|:..::...| :.|......|
Human   537 MMALQTDIVDLQRSPMGRKQGGTL-------DDLEEQARELYRRLRE-KPRDQRTEGD------- 586

  Fly   630 KTKESIPVLLQQFCDIKKEIFQINLQM 656
             ::|.:.:|||.....:|::..|..|:
Human   587 -SQEMVRLLLQAIQSFEKKVRVIYTQL 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567	90/244 (37%)
IKKbeta	NP_524751.3	PKc_like	13..316	CDD:304357	107/309 (35%)
IKBKB	XP_005273547.1	S_TKc	15..290	CDD:214567	104/297 (35%)
		STKc_IKK_beta	20..309	CDD:270940	108/311 (35%)
		GVQW	785..>805	CDD:290611
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156299
Domainoid	1	1.000	159	1.000	Domainoid score	I4088
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013139at2759
OrthoFinder	1	1.000	-	-		FOG0003594
OrthoInspector	1	1.000	-	-		otm41786
orthoMCL	1	0.900	-	-		OOG6_105964
Panther	1	1.100	-	-	LDO	PTHR22969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6738
SonicParanoid	1	1.000	-	-		X2467
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.740