DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IKKbeta and IKKepsilon

DIOPT Version :9

Sequence 1:	NP_524751.3	Gene:	IKKbeta / 44432	FlyBaseID:	FBgn0024222	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_610048.2	Gene:	IKKepsilon / 35329	FlyBaseID:	FBgn0086657	Length:	720	Species:	Drosophila melanogaster

Alignment Length:	791	Identity:	188/791 - (23%)
Similarity:	297/791 - (37%)	Gaps:	194/791 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WERCRNLGEGGFGLVIHWRNRTTGREIATK------HIKEMGALSADQQVKLSERWNKELNWSRQ 65
            |.....||:|..|.|....|:.||..:|.|      |::     .||.|::..|...|
  Fly    12 WCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMR-----PADVQMREFEALKK------- 64

  Fly    66 FKNFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQIL 130
             .|..:||..:.||:..         ..:..|||:|.|.||.:...|..|||:.||.|.|...:|
  Fly    65 -VNHENIVKLLAIEEDQ---------EGRGKVIVMELCTGGSLFNILDDPENSYGLPEHEFLLVL 119

  Fly   131 GALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYY 195
            ..|...:..|... .:.||||||.||:.....||:.||||||||.||...|.....|:.||..|.
  Fly   120 EHLCAGMKHLRDN-KLVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGTEEYL 183

  Fly   196 APEVVENGF--------YNSTVDLWSFGVIAYELVTGELPFIPHQTLKN--IILNLIKKPAKCIA 250
            .|::.|...        :.:.|||||.||..|.:.||.|||.|....||  .:..:..|.|..:.
  Fly   184 HPDLYERAVLRKSIQRSFTANVDLWSIGVTLYHVATGNLPFRPFGGRKNRETMHQITTKKASGVI 248

  Fly   251 ITEDPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPVVFADLDKIL 315
            ......:|........||...|||     |..|.|.:||.:...|..:....:....|.::..||
  Fly   249 SGTQLSENGPIEWSTTLPPHAHLS-----QGLKTLVTPLLAGLLEENREKTWSFDRFFHEVTLIL 308

  Fly   316 NMNVLTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTGMDEKELYFVLPTSHPHKTITPKSTPLQ 380
            ...|:.:|..|....:|..:..:..:.:....|.|.|.:..::...:....|..|.:||::
  Fly   309 RKRVIHVFFTNRTSSVEVFLEPDEQIDNFRERIFLQTEVPLEKQILLFNNEHLEKKVTPRT---- 369

  Fly   381 LYVEEWSDTSKDSRKWTKRSNPPVMLYI-----FQVKKECDY-KIP--EPILSILSRKFIANKFK 437
             ..:.:..|:.|.         |:.||.     .|:.::.|. |.|  .|.:|:.:...:|....
  Fly   370 -IAKAFPATTTDQ---------PIFLYSNDDNNVQLPQQLDLPKFPVFPPNVSVENDASLAKSAC 424

  Fly   438 TKERWLQKRV-VLDMLYVLTKEQARY--EMLVSGINERALSLEDEMMENSFIDSIDKQRIIISFA 499
            :.....::|| :...:.:|.|:...:  ||||:.|.  .|..:.|..:|.....||...::.|.|
  Fly   425 SVGHECKRRVDIFTSMDILIKKGVEHFIEMLVTTIT--LLLKKTESFDNLLSTVIDYADVVHSMA 487

  Fly   500 -------------------------------------------YDQLTSLL----------KEAQ 511
                                                       .||.||.:          ..||
  Fly   488 RVTKGDQEIKTLLTALENVKSDFDGAADVISQMHKHFVIDDELNDQWTSSMHGKKCPCKTRASAQ 552

  Fly   512 AKIPSRQLISSAQWEKLNRN-------YN----------FIIQSAKSIRSFL-----------EA 548
            ||....:|..|  |:.|.|:       ||          .:..:.|.|::.|           ..
  Fly   553 AKYLVERLRDS--WQHLLRDRATRTLTYNDEQFHALEKIKVDHNGKRIKALLLDNVNPTVAQIAE 615

  Fly   549 CLREAKDMVKTTNQLRKEVCEKDLFDCARFYKKYLCNGAIISPSELNNDAEEF--AKSRFKLYNE 611
            ||.:...:.:|. .|:.::.|||:.||.|               :||...:|.  .||..||..:
  Fly   616 CLADWYKLAQTV-YLKTQILEKDVRDCER---------------KLNGIRDELYHVKSELKLDVD 664

  Fly   612 GEARHLPKSIDHMHYL-YFKTKESIPVLLQQFCDIKKEIFQINLQMLMSASSTPPPKLELSAAMD 675
                  .|:|::.:.| ..:.:..:.|:.||         |..:..:|..:|      ::.:.:.
  Fly   665 ------TKTINNNNQLAKIEERNRLRVMQQQ---------QQEVMAVMRTNS------DIISLLS 708

  Fly   676 RLAISSGSPSS 686
            :|.|::||..|
  Fly   709 KLGITNGSLES 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567	83/253 (33%)
IKKbeta	NP_524751.3	PKc_like	13..316	CDD:304357	98/318 (31%)
IKKepsilon	NP_610048.2	Pkinase	16..297	CDD:278497	96/308 (31%)
		STKc_TBK1	18..332	CDD:270890	103/341 (30%)
		UBL_TBK1_like	299..389	CDD:240618	19/103 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463164
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4250
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22969
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840