Protein Alignment IKKbeta and IKKbeta

DIOPT Version :10

• Sequence 1: NP_524751.3
• Gene: IKKbeta / 44432
• FlyBaseID: FBgn0024222
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: XP_061510813.1
• Gene: IKKbeta / 3291915
• VectorBaseID: AGAMI1_001872
• Length: 812
• Species: Anopheles gambiae
• Alignment Length: 777
• Identity: 213/777 - (27%)
• Similarity: 355/777 - (45%)
• Gaps: 145/777 - (18%)

  Fly     5 GNWERCRNLGEGGFGLVIHWRNRTTGREIATK--HIKEMGALSADQQVKLSERWNKELNWSRQFK 67
            |.|.|.:.||.||||:|..|||:.|.:.:|.|  ||.:..:...|   |..|||..|:....:..
Mosquito    12 GEWCREKRLGNGGFGVVTLWRNKQTQQAVAIKKFHILQDRSEITD---KHCERWRNEVKLMTETV 73

  Fly    68 NFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGA 132
            ...|||..||::...|:|.|....:..|||:.:|||.|||:|:.|...||.:||.|.:||.:|.:
Mosquito    74 QNDHIVRTVDVQPRAFIEELLRSSANGLPVLCMEYCEGGDLRRVLNRVENCSGLREQDVRDVLRS 138

  Fly   133 LRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAP 197
            ||.|:.:||| ..|.|||:||:|:|:::..| :.||||||.|.|:....|::..|:|||..|.||
Mosquito   139 LRSAIAYLHS-LKITHRDIKPENLVLKQHGD-RFIYKLTDLGYAKALDKQSLNASLVGTVEYIAP 201

  Fly   198 EVVENGFYNSTVDLWSFGVIAYELVTGELPFIPHQTLKNIILNLIKKPAKCIAITEDPEDNTRFV 262
            :::....||.:||.||.|||.:|:|||..|||||..:...::::.:|.:..||||||..:|  :.
Mosquito   202 DLIYCDRYNCSVDYWSMGVIGFEIVTGVRPFIPHAPITRWMMHVQQKKSADIAITEDNREN--YT 264

  Fly   263 NQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQL-----AANNVP---VVFAD--------- 310
            ...|:...:|:|.....|..:||...|..|.|:||.:     .|.:.|   |.||:
Mosquito   265 YHTEIFAENHISTCLRKQLERWLMLALEWNPKQRGYVPYSATVAEDTPPKSVTFAEDSRPGGSTV 329

  Fly   311 ------LDKILNMNVLTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTGMDEKELYFVLPTSHPH 369
                  ||:||:..:|.:|::::|..::..|:.:.:|..:...:...||:...|:.|:||.....
Mosquito   330 LKIFSLLDQILDKRILVLFSLHDCRWIDLEVTPDTSMAVVREHVYQLTGIPVDEIEFILPLEQKQ 394

  Fly   370 KTITPKSTPLQLYVEEWSDTSKDSRKWTKRSNPPVMLYIFQ-------VKKECDYKIPEPILSI- 426
            ..:...:.|..||:.:.|            |..| |:|:..       |:::...:||:.|..:
Mosquito   395 PRVGSDTRPYDLYLADLS------------SGKP-MVYVAHRASRESIVQRDLKPRIPKSITDVF 446

  Fly   427 ----------LSRKFIANKFKTKERWLQKRVVLDMLYVLTKEQARYEMLVSGINERALSLEDEMM 481
                      :.|:||||.:                |.:..||..|.:|:.|:....|:|.|.:.
Mosquito   447 QNIKVKLKPHMLRQFIANAY----------------YFIANEQRLYVLLLDGVRNYGLTLNDAIA 495

  Fly   482 EN------------SFIDSIDKQRIIISFAYDQLTSLLKEAQAKIPSRQL-ISSAQWE----KLN 529
            ..            ..:..::..::.:|...|.|     .|..:|||... .:|.|||    ::.
Mosquito   496 RRKEEIGRMNKVVYGIVGGVEYHKLTVSHTRDAL-----NAGKRIPSASFETASHQWEEKCSRVE 555

  Fly   530 RNYNFIIQSAKSIRSFLEACLREAKDMVKTTNQLRKEVCEKDLFDCARFYKKYLCNGAIISPSEL 594
            .|...:.:.|..|....|:.|:.::|.::  :.|.:|..::|.|.......:|
Mosquito   556 TNVRKLAEMADKISKRYESVLKRSRDALR--HALLQEYEQQDYFGLKTVEGRY------------ 606

  Fly   595 NNDAEEFAKSRF--KLYNEGEARHLPKSIDHMHYLYFKTKESIPVLL---------QQFCDIKKE 648
                 |..::|.  |:.||.....:.:::    |...|.::   |||         :|..|::.|
Mosquito   607 -----EQTRARILEKITNEKSHMDMSQAV----YECLKRRD---VLLRDAGFLELQRQLLDVRHE 659

  Fly   649 IFQINLQMLMSASSTPPPKLELSAAMDRLAISSGSPSSDPFDSLRTINAIEEAERINNILVN 710
            :.:|...:......|...|.||:    ||.:..   ..:.:..|.:::|..:|...|..|.|
Mosquito   660 MQEIEKVLEKVVELTEKYKRELA----RLTLEH---QDEVWKMLSSVDANGQAVTTNGTLSN 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	Protein Kinases, catalytic domain	13..316	CDD:473864	124/327 (38%)
IKKbeta	XP_061510813.1	None