DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IKKbeta and TBK1

DIOPT Version :9

Sequence 1:	NP_524751.3	Gene:	IKKbeta / 44432	FlyBaseID:	FBgn0024222	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_037386.1	Gene:	TBK1 / 29110	HGNCID:	11584	Length:	729	Species:	Homo sapiens

Alignment Length:	739	Identity:	178/739 - (24%)
Similarity:	274/739 - (37%)	Gaps:	222/739 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHSFGN--WERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGAL-SADQQVKLSERWNKELNW 62
            |.|..|  |.....||:|....|...|::.||...|.|....:..| ..|.|::..|.. |:||
Human     1 MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVL-KKLN- 63

  Fly    63 SRQFKNFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFE-- 125
               .||...:.|   ||:..         :.:..|:::|:|..|.:...|:.|.||.||.|.|
Human    64 ---HKNIVKLFA---IEEET---------TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFL 113

  Fly   126 --VRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSV 188
              :|.::|.:.   |...:  ||.|||:||.||:...|.||:.:|||||||.||...|.....|:
Human   114 IVLRDVVGGMN---HLREN--GIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSL 173

  Fly   189 VGTRHYYAPEVVENGF--------YNSTVDLWSFGVIAYELVTGELPFIPHQ---TLKNIILNLI 242
            .||..|..|::.|...        |.:||||||.||..|...||.|||.|.:   ..|.::..:|
Human   174 YGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238

  Fly   243 K-KPAKCIAITEDPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPV 306
            . ||:..|:..:..| |.......::|.:..|||.     .:.|.:|:.:|..|..|........
Human   239 TGKPSGAISGVQKAE-NGPIDWSGDMPVSCSLSRG-----LQVLLTPVLANILEADQEKCWGFDQ 297

  Fly   307 VFADLDKILNMNVLTIFAVN------------NCERLEYAVSAEMTM-----KDLI---ALIVLD 351
            .||:...||:..|:.:|::.            |...:.:.:..:.|.     ::||   ..:||:
Human   298 FFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLE 362

  Fly   352 TG---------MDEKELYFV----------------LPTSHPH----------KTITPK------ 375
            .|         .:|..::.|                ||..||.          |.||..
Human   363 PGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACR 427

  Fly   376 -STPLQLYVE------EW-SDTSKDSRKWTKRSNPPVMLYI-FQVKK-ECDYKIPEPILSI---- 426
             ::.|.||.|      .| .:..||....|......|::.: |.::. |...|:.|.::.|
Human   428 IASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEA 492

  Fly   427 --------LSRKFI------------------------------ANKFKT--KERWLQKRVVL-- 449
                    :..|.:                              |::..|  |:|.::|..||
Human   493 AELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLN 557

  Fly   450 ---DMLYVLTKEQARYEMLVSGINERALSLEDEMMENSFIDSIDKQRIIISFAYDQLTSLLKEAQ 511
               ::.|...|::|          ||.|:..:|.     |...|||::.. .|...:|....|..
Human   558 CMTEIYYQFKKDKA----------ERRLAYNEEQ-----IHKFDKQKLYY-HATKAMTHFTDECV 606

  Fly   512 AKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSFLEACLREAKDMVKTTNQLRKEVCEKDLFDCA 576
            .|..:                 |:.:|.:.||..|.  ||  |.::..|||     |    ||..
Human   607 KKYEA-----------------FLNKSEEWIRKMLH--LR--KQLLSLTNQ-----C----FDIE 641

  Fly   577 RFYKKYLCNGAIISPSELNNDAEE 600
            ....||         .|..|:.:|
Human   642 EEVSKY---------QEYTNELQE 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567	83/254 (33%)
IKKbeta	NP_524751.3	PKc_like	13..316	CDD:304357	99/319 (31%)
TBK1	NP_037386.1	S_TKc	9..242	CDD:214567	83/254 (33%)
		STKc_TBK1	15..330	CDD:270890	102/342 (30%)
		UBL_TBK1_like	297..385	CDD:240618	15/87 (17%)
		Interaction with AZI2, TANK and TBKBP1. /evidence=ECO:0000269\|PubMed:21931631	621..729		16/58 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810