DRSC/TRiP Functional Genomics Resources

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Protein Alignment IKKbeta and Ikbkb

DIOPT Version :10

Sequence 1:NP_524751.3 Gene:IKKbeta / 44432 FlyBaseID:FBgn0024222 Length:717 Species:Drosophila melanogaster
Sequence 2:NP_001153246.1 Gene:Ikbkb / 16150 MGIID:1338071 Length:757 Species:Mus musculus


Alignment Length:683 Identity:185/683 - (27%)
Similarity:298/683 - (43%) Gaps:114/683 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 GNWERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWSRQFKNF 69
            |.||....||.||||.||.|.|:.||.:||.|..::      :...|..:||..|:...|:. |.
Mouse    13 GAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQ------ELSPKNRDRWCLEIQIMRRL-NH 70

  Fly    70 PHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGALR 134
            |::||..|:.     |.:..:....||::.:|||.|||:|:.|...||..||.|..|..:|..:.
Mouse    71 PNVVAARDVP-----EGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREGAVLTLLSDIA 130

  Fly   135 KALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAPEV 199
            .||.:||.. .|.||||||:|||:|:| :.:.|:|:.|.|.|:.....::..|.|||..|.|||:
Mouse   131 SALRYLHEN-RIIHRDLKPENIVLQQG-EKRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPEL 193

  Fly   200 VENGFYNSTVDLWSFGVIAYELVTGELPFIP-------HQTLKNIILNLIKKPAKCIAITEDPED 257
            :|...|..|||.||||.:|:|.:||..||:|       |..::       :|....|.::||...
Mouse   194 LEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVR-------QKSEVDIVVSEDLNG 251

  Fly   258 NTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERG---QLAANNVPVVFADLDKILNMNV 319
            ..:|.:  .||..::|:...|.:..|||...|..:.::||   |...|.   .|..||.|||:.:
Mouse   252 AVKFSS--SLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNG---CFRALDDILNLKL 311

  Fly   320 LTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTGM--DEKEL-----YFVLPTSHPHKTITPKST 377
            :.:..:.......|.|:.:.:::.|...|..|||:  .::||     ..:||.....:.|:...|
Mouse   312 VHVLNMVTGTVHTYPVTEDESLQSLKTRIQEDTGILETDQELLQEAGLVLLPDKPATQCISDSKT 376

  Fly   378 ----PLQLYVEEWSDTSKDS--RKWTKRSNPPVMLYIFQVKKECDYKIPEPILSILSRKFIANKF 436
                .|.:.:....|.||.:  .:.|.|..|..:        .|..:.|:..||.         |
Mouse   377 NEGLTLDMDLVFLFDNSKINYETQITPRPQPESV--------SCILQEPKRNLSF---------F 424

  Fly   437 KTKERWLQKRVVLDMLYVLTKEQARYEMLVSGINERALSLEDEMMENSFIDSIDKQRIIISFAYD 501
            :.::.|.|   |...:..|.::..|   |..|.....:||   :..||.:..:.          :
Mouse   425 QLRKVWGQ---VWHSIQTLKEDCNR---LQQGQRAAMMSL---LRNNSCLSKMK----------N 470

  Fly   502 QLTSLLKEAQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSF------LEACLRE--AKDMVK 558
            .:.|..::.:||:...:.......||......|.|.|.|.:.::      :|.|.||  .|.:|:
Mouse   471 AMASTAQQLKAKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVE 535

  Fly   559 TTNQLRKEVCEKDLFDCARFYKKYLCNGAIISPSELNNDAEEFAKSRFKLYNEGEARHLPKSIDH 623
                 |....:.|:.|..|........|.:       :|.||.|:..::...| :.|......| 
Mouse   536 -----RMMALQTDIVDLQRSPMGRKQGGTL-------DDLEEQARELYRRLRE-KPRDQRTEGD- 586

  Fly   624 MHYLYFKTKESIPVLLQQFCDIKKEIFQINLQM 656
                   ::|.:.:|||.....:|::..|..|:
Mouse   587 -------SQEMVRLLLQAIQSFEKKVRVIYTQL 612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IKKbetaNP_524751.3 Protein Kinases, catalytic domain 13..316 CDD:473864 110/312 (35%)
IkbkbNP_001153246.1 STKc_IKK_beta 20..309 CDD:270940 111/314 (35%)
Ubl_IKKA_like 310..390 CDD:340566 14/79 (18%)
IKBKB_SDD 389..663 CDD:465745 56/281 (20%)
Leucine-zipper 458..479 4/33 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 683..703
IKKbetaNEMObind 706..742 CDD:463485
NEMO-binding. /evidence=ECO:0000250|UniProtKB:O14920 737..742
Blue background indicates that the domain is not in the aligned region.

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