Protein Alignment IKKbeta and IKKepsilon

DIOPT Version :10

• Sequence 1: NP_524751.3
• Gene: IKKbeta / 44432
• FlyBaseID: FBgn0024222
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: XP_318573.4
• Gene: IKKepsilon / 1278956
• VectorBaseID: AGAMI1_003749
• Length: 763
• Species: Anopheles gambiae
• Alignment Length: 741
• Identity: 181/741 - (24%)
• Similarity: 293/741 - (39%)
• Gaps: 168/741 - (22%)

  Fly     1 MHSF--GN----WERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKE 59
            |:||  |:    |.....||:|..|.|....|:..|..:|.|...::..: ..|.|::
Mosquito     1 MNSFLRGSMNYVWCTTSVLGKGSTGAVFQGVNKHNGEPVAVKTFNQLSHM-RPQDVQM------- 57

  Fly    60 LNWSRQFK-----NFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENAN 119
                |:|:     |..:||..:||||..         ..:..|||:|.|.||.:...|..|||..
Mosquito    58 ----REFEVLRKVNHNNIVKLLDIEDDQ---------EGRGKVIVMELCTGGSLFNILDDPENTY 109

  Fly   120 GLTEFEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTM 184
            ||.:.|...:|..|...:..|... .:.||||||.||:.....||:.:|||||||.||...:...
Mosquito   110 GLQQKEFLLVLEHLSAGMKHLRDN-NLVHRDLKPGNIMKYISEDGQTVYKLTDFGAARELGENQQ 173

  Fly   185 VQSVVGTRHYYAPEVVE--------NGFYNSTVDLWSFGVIAYELVTGELPFIPH------QTLK 235
            ..|:.||..|..|::.|        |..:.:.|||||.||..|.:.||.|||.|:      :|:.
Mosquito   174 FASLYGTEEYLHPDMYERAVLRKSINRSFTANVDLWSIGVTLYHVATGNLPFRPYGGRKNKETMY 238

  Fly   236 NIILNLIKKPAKCIAITEDPEDNTRFVNQFELPQTHHLSRPWAAQF---TKWLASPLNSNYKERG 297
            :|   ..||....|:.|:..|:.       .:..:.||  |...|.   .|.|.:||.:...|..
Mosquito   239 HI---TTKKAPGVISGTQTSENG-------PIEWSKHL--PAHCQLKEGLKQLVTPLMAGLLEES 291

  Fly   298 QLAANNVPVVFADLDKILNMNVLTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTGMDEKELYFV 362
            |....:....|.::..|||..||.||.||....:|..:..|.|:..|:..|:..|.:
Mosquito   292 QGRMWSFDKFFLEVQNILNKTVLHIFYVNRATSIEVYLEPEQTLVHLLEHILAQTDV-------- 348

  Fly   363 LPTSHPHKTITPKSTPLQLYVEEWSDTSKDSRKWTKRSNP-----PVMLYIFQVKKECDYKIPEP 422
                       |:::.|.|...|...|..|:....:...|     ||||:..:     :|.:
Mosquito   349 -----------PQASQLLLLDNELFATKVDANTSARGYPPTDPSNPVMLFNIE-----NYNV--- 394

  Fly   423 ILSILSRKFIANKFKT-----------------------KERWLQKRVVLDMLYVLTKEQARYEM 464
               ||..::...||.|                       .:|.::...:||.|  :.|...::..
Mosquito   395 ---ILPTEWDLPKFPTFPNGISVENDASLAKVACSVGHECKRRVESLSLLDTL--MNKSVHQFSG 454

  Fly   465 LVSG----INERALSLED---------EMMENSFIDSIDKQR----IIISFA-----YDQLTSLL 507
            .::|    :.:|...|||         :|.|.:..:....|:    |:.|:.     :.:::..:
Mosquito   455 FLAGFLVKLLKRTRHLEDIEGLISELTKMFEVAASNHETYQKLGATILASYETQKSDFQRVSEPI 519

  Fly   508 KEAQAK-IPSRQLISSAQWEKLNR-----NYNFIIQSAKS----IRSFLEACLREAKDMVKTTNQ 562
            ::..|: :....|:  .:|....|     |.|...:.|||    :|...:..||:......|.|.
Mosquito   520 QQLYARFVKEESLV--REWNSGYRALRTPNKNRDSEKAKSLVDRLRDSWQHMLRDRATRSLTYND 582

  Fly   563 LRKEVCEK-DLFDCARFYKKYLCNG---AIISPSELNNDAEEFAKSRFKLYNEGEARHLPKSIDH 623
            .:..|.|| .:.:..:..|..|.:|   |:...:|...|..:.|::.|.     :.:.|.|.:..
Mosquito   583 EQFHVLEKVKIAETGKRLKTLLNDGVRQAVEQEAECLADWYKKAQTIFL-----QTQFLTKDVGA 642

  Fly   624 MHYLYFKTKESIPVLLQQFCDIKKEI 649
            .....::.:|.   |.|...|:|:||
Mosquito   643 YVDALYELREQ---LKQHREDLKEEI 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	Protein Kinases, catalytic domain	13..316	CDD:473864	96/324 (30%)
IKKepsilon	XP_318573.4	None