DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IKKbeta and Chuk

DIOPT Version :9

Sequence 1:	NP_524751.3	Gene:	IKKbeta / 44432	FlyBaseID:	FBgn0024222	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_030106592.1	Gene:	Chuk / 12675	MGIID:	99484	Length:	757	Species:	Mus musculus

Alignment Length:	695	Identity:	184/695 - (26%)
Similarity:	298/695 - (42%)	Gaps:	151/695 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GNWERCRNLGEGGFGLVIHWRNRTTGREIATKHIK-EMGALSADQQVKLSERWNKELNWSRQFKN 68
            |.||....||.||||.|..:::|....:||.|..: |:.:       |..|||..|:...::. :
Mouse    13 GPWEMRERLGTGGFGNVSLYQHRELDLKIAIKSCRLELSS-------KNRERWCHEIQIMKKL-D 69

  Fly    69 FPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGAL 133
            ..::|...|:  |:.|.:|..    .:|::.:|||:|||:||.|..|||..||.|.::..:|..:
Mouse    70 HANVVKACDV--PEELNFLIN----DVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDI 128

  Fly   134 RKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAPE 198
            ...:.:||.. .|.||||||:|||:| .|.||.|:|:.|.|.|:.....::..|.|||..|.|||
Mouse   129 GSGIRYLHEN-KIIHRDLKPENIVLQ-DVGGKTIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPE 191

  Fly   199 VVENGFYNSTVDLWSFGVIAYELVTGELPFIP-------HQTLKNIILNLIKKPAKCIAITEDPE 256
            :.||..|.:|||.||||.:.:|.:.|..||:.       |:.:|       ||..|||...|:..
Mouse   192 LFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIK-------KKDPKCIFACEEMT 249

  Fly   257 DNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERG---QLAANNVPVVFADLDKILNMN 318
            ...||.:  .|||.:.|..........||...||.:.::||   .|.... |..||.:|.|||:.
Mouse   250 GEVRFSS--HLPQPNSLCSLIVEPMESWLQLMLNWDPQQRGGPIDLTLKQ-PRCFALMDHILNLK 311

  Fly   319 VLTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTGMD--EKELYFVLPTSHPHKTITPKSTPLQL 381
            ::.|..:.:.:.:.:.:..:.::..|.:.|..:||::  .:||     .|....::.|:....|.
Mouse   312 IVHILNMTSAKIISFLLPCDESLHSLQSRIERETGINTGSQEL-----LSETGISLDPRKPASQC 371

  Fly   382 ----------YVEEWSDTSKD--SRKWTKRSNPPVMLYIFQVKKECDYKIPEPILSILSRKFIAN 434
                      |:....|.||.  ...:..||....:.||.|     |.||..||:.:
Mouse   372 VLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQ-----DSKIQLPIIQL-------- 423

  Fly   435 KFKTKERWLQKRVVLDMLYVLTKEQARYEMLVSGINERALSLEDEMMENSFIDSIDKQRIIISFA 499
                      ::|..:.::.::..:..|..|..|.....|||   :..|:   ::.|.:..:..|
Mouse   424 ----------RKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSL---LRYNA---NLTKMKNTLISA 472

  Fly   500 YDQLTSLLKEAQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSFLEACLREAKDMVKTTNQLR 564
            ..||.:.|:..:..|   ||    ..|:.:....:.|.|.|.::::
Mouse   473 SQQLKAKLEFFRKSI---QL----DLERYSEQMTYGISSEKMLKAW------------------- 511

  Fly   565 KEVCEKDLFDCARFYKK-----YLCNGAIISPSELNNDAEEFAKSRF----------------KL 608
            ||:.||     |..|.:     || ...|:|   |:.:..|..||.:                .|
Mouse   512 KEMEEK-----AIHYSEVGVIGYL-EDQIMS---LHTEIMELQKSPYGRRQGDLMESLEQRAIDL 567

  Fly   609 YNEGEARHLPKSIDHMHYLYFKTKESIPVL---LQQFCDIKKEIF 650
            |.  :.:|.|.  ||   ||..:.|.:.::   :|....:.||:|
Mouse   568 YK--QLKHRPP--DH---LYSDSTEMVKIIVHTVQSQDRVLKELF 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567	87/245 (36%)
IKKbeta	NP_524751.3	PKc_like	13..316	CDD:304357	108/313 (35%)
Chuk	XP_030106592.1	STKc_IKK_alpha	21..309	CDD:270941	108/313 (35%)
		Ubl_IKKA_like	311..387	CDD:340566	11/80 (14%)
		IKBKB_SDD	386..659	CDD:375823	60/291 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846706
Domainoid	1	1.000	159	1.000	Domainoid score	I4077
eggNOG	1	0.900	-	-		E2759_KOG4250
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4396
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013139at2759
OrthoFinder	1	1.000	-	-		FOG0003594
OrthoInspector	1	1.000	-	-		otm43838
orthoMCL	1	0.900	-	-		OOG6_105964
Panther	1	1.100	-	-	O	PTHR22969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6738
SonicParanoid	1	1.000	-	-		X2467
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.690