Protein Alignment IKKbeta and ERLIN1

DIOPT Version :9

• Sequence 1: NP_524751.3
• Gene: IKKbeta / 44432
• FlyBaseID: FBgn0024222
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: NP_001094096.1
• Gene: ERLIN1 / 10613
• HGNCID: 16947
• Length: 348
• Species: Homo sapiens
• Alignment Length: 262
• Identity: 45/262 - (17%)
• Similarity: 92/262 - (35%)
• Gaps: 77/262 - (29%)

  Fly   483 NSFIDSIDKQRIIISFAYDQLTSLLKEA--------------------QAKIPSRQLISSAQWEK 527
            |.|..:...|.:.|.. :||:...||:|                    :.|||          |.
Human   127 NQFCSAHTLQEVYIEL-FDQIDENLKQALQKDLNLMAPGLTIQAVRVTKPKIP----------EA 180

  Fly   528 LNRNYNFIIQSAKSIRSFLEACLREAKDMVKTTNQLRKEVCEKDLFDCA--RFYKKY-------- 582
            :.|  ||.:..|:..:..:.|..::..:....|.:.:..:..:.:...|  ||.:|.
Human   181 IRR--NFELMEAEKTKLLIAAQKQKVVEKEAETERKKAVIEAEKIAQVAKIRFQQKVMEKETEKR 243

  Fly   583 ---LCNGAIISPSELNNDAEEFAKSRFKLYNEGEARHLPKSIDHMHYLYFKTKESIPVLLQQFCD 644
               :.:.|.::..:...|||.:|..::...|:.:                        |..::.:
Human   244 ISEIEDAAFLAREKAKADAEYYAAHKYATSNKHK------------------------LTPEYLE 284

  Fly   645 IKKEIFQINLQMLMSASSTPPPKLELSAAMDRLAISSGSPSSDPFDSLRTINAIEEAERINNILV 709
            :||.....:...:...|:.|...::.|.|:....|.:|..||.|     :..|:|.:.  .|::.
Human   285 LKKYQAIASNSKIYFGSNIPNMFVDSSCALKYSDIRTGRESSLP-----SKEALEPSG--ENVIQ 342

  Fly   710 NE 711
            |:
Human   343 NK 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567
		PKc_like	13..316	CDD:304357
ERLIN1	NP_001094096.1	SPFH_like_u3	23..310	CDD:259804	34/219 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	325..348		7/27 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4396
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950