DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IKKbeta and LOC101732839

DIOPT Version :9

Sequence 1:	NP_524751.3	Gene:	IKKbeta / 44432	FlyBaseID:	FBgn0024222	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001297046.1	Gene:	LOC101732839 / 101732839	-ID:	-	Length:	743	Species:	Xenopus tropicalis

Alignment Length:	772	Identity:	197/772 - (25%)
Similarity:	317/772 - (41%)	Gaps:	153/772 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GNWERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWSRQFKNF 69
            |.|:....||.||||.|..::||.||      .:|.:.:...:..:|..|||.:|:...::. |.
Frog    13 GPWDMKDRLGTGGFGNVCLYQNRETG------ELKAIKSCRLELSMKNKERWCQEIQIMKRL-NH 70

  Fly    70 PHIVAGVDI-EDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGAL 133
            |::|...:: .:.|||  :|     .:|.:.:|||.|||:||.|..|||..||.|.:|..::..:
Frog    71 PNVVKACEVPPEMDFL--VN-----DVPHLAMEYCAGGDLRKLLNKPENCCGLKESQVLNLMSDI 128

  Fly   134 RKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAPE 198
            ...:.:||.: .|.||||||:|||:|. .:||.::|:.|.|.|:.....::..|.|||..|.|||
Frog   129 GSGIQYLHEK-RIIHRDLKPENIVLQE-CNGKTVHKIIDLGYAKDLDQGSLCTSFVGTLQYLAPE 191

  Fly   199 VVENGFYNSTVDLWSFGVIAYELVTGELPFIP-------HQTLKNIILNLIKKPAKCIAITEDPE 256
            :.||..|:.|||.||||.:.:|.:.|..||:.       |:.:|       ||..|.|...|:..
Frog   192 LFENKPYSVTVDYWSFGTMVFECIAGFRPFLHNMQPFTWHEKIK-------KKDHKHIYAYEEMS 249

  Fly   257 DNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPVVFADLDKILNMNVLT 321
            ...||.:.  |||.::|......:...||...||.:..:||.......|..|..:|:|||:.::.
Frog   250 GEIRFSSY--LPQPNNLCSIIVDKIETWLQLLLNWDPIQRGGGMDCGRPQCFVLMDQILNLKIVH 312

  Fly   322 IFAVNNCERLEYAVSAEMTMKDLIALIVLDTGMD--EKELYFVLPTS-HPHKTITPKSTPLQLYV 383
            |..:.:.:...:.:..|.::..|.:.|..:||:.  .:||...:..| .|.|   |.|..:...|
Frog   313 ILNMTSAKIHSFHLQPEESLHTLQSRIETETGISTCNQELLLEMGVSLDPRK---PASQCVIDGV 374

  Fly   384 EEWSDTSKDSRKWTKRSNPPVMLYIFQVKK-------------EC------DYKIPEPILSILSR 429
            :.|     ||          .|:|:|...|             ||      |.|:..||..:
Frog   375 KGW-----DS----------YMVYLFDKSKTVYEGPFQSRSLSECLNYIVQDSKVQLPIPQL--- 421

  Fly   430 KFIANKFKTKERWLQKRVVLDMLYVLTKEQARYEMLVSGINERALSLEDEMMENSFIDSIDKQRI 494
                           ::|..:.::.::..:..|..|..|.....|||      ..|..::.|.:.
Frog   422 ---------------RKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSL------LRFNTNLTKMKN 465

  Fly   495 IISFAYDQLTSLLKEAQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSFLE-----ACLREAK 554
            .:..|..||.:.|:..:..|       ....|:.:....:.|.|.|.:|::.|     .|..:|.
Frog   466 TMVSASQQLGAKLQFFKRSI-------EIDLERYSDQMAYGISSEKMLRAWKEMEDKAVCFGKAG 523

  Fly   555 D---MVKTTNQLRKEVCEKDLFDCAR---------------FYKKYLCNGAIISPSELNNDAEEF 601
            .   :.:|...|..|:.|.....|||               .||:....    ||.:..:|:.|.
Frog   524 KIHFLDETIMGLHTEIVELQKSPCARRQGDVMEHLEQRAMELYKQLKPR----SPDKAYSDSTEM 584

  Fly   602 AKSRFKLYNEGEARHLPKSIDHMHYL-----------------YFKTKESIPVLLQQFCDIKKEI 649
            .|...:.. :|:.|.|.:...|:..|                 ....||:...|:|.....::||
Frog   585 VKILVQTV-QGQDRVLKELFGHLSKLLGCKQKIIDLLPQIEMTVNNIKEADSSLMQMQAKRQREI 648

  Fly   650 FQINLQML---MSASSTPPPKLELSAAMDRLAISSGSPSSDPFDSLRTINAIEEAER 703
            :.: |::.   .||.|..|..:|........|....|.|...|..|.|.:...|..|
Frog   649 WHL-LKIACTQSSARSLGPASVETPITPRTSAWPDQSSSQALFSMLTTKDKSREILR 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567	86/245 (35%)
IKKbeta	NP_524751.3	PKc_like	13..316	CDD:304357	105/310 (34%)
LOC101732839	NP_001297046.1	PKc_like	21..307	CDD:389743	105/310 (34%)
		Ubl_IKKA_like	309..385	CDD:340566	19/93 (20%)
		IKBKB_SDD	384..657	CDD:375823	56/309 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	152	1.000	Domainoid score	I4282
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1013139at2759
OrthoFinder	1	1.000	-	-		FOG0003594
OrthoInspector	1	1.000	-	-		otm49011
Panther	1	1.100	-	-	O	PTHR22969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6738
SonicParanoid	1	1.000	-	-		X2467
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.050