DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IKKbeta and tbk1

DIOPT Version :9

Sequence 1:	NP_524751.3	Gene:	IKKbeta / 44432	FlyBaseID:	FBgn0024222	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001135652.1	Gene:	tbk1 / 100216212	XenbaseID:	XB-GENE-955452	Length:	725	Species:	Xenopus tropicalis

Alignment Length:	688	Identity:	169/688 - (24%)
Similarity:	268/688 - (38%)	Gaps:	144/688 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHSFGN--WERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGAL-SADQQVKLSERWNKELNW 62
            |.|..|  |.....||:|....|...||:.||...|.|....:..| .||.|::..|.. |:||
Frog     1 MQSTANHLWLLSDILGQGATANVYRGRNKKTGDLYAVKVFNNLSFLRPADVQMREFEVL-KKLN- 63

  Fly    63 SRQFKNFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVR 127
               .||...:.|   ||:.         .|::..|:|:|:|....:...|:.|.||.||.|.|..
Frog    64 ---HKNIVKLFA---IEEE---------MSSRHKVLVMEFCPCASLYSVLEEPANAYGLPESEFL 113

  Fly   128 QILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTR 192
            .:...:...::.|... ||.|||:||.||:...|.||:.:|||||||.||...|.....|:.||.
Frog   114 IVSRDVVAGMNHLREN-GIIHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELDDDEQFVSLYGTE 177

  Fly   193 HYYAPEVVENGF--------YNSTVDLWSFGVIAYELVTGELPFIPHQ---TLKNIILNLIK-KP 245
            .|..|::.|...        |.:||||||.||..|...||.|||.|.:   ..|.::..:|. ||
Frog   178 EYLHPDMYERAVLRKEHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIIAGKP 242

  Fly   246 AKCIAITEDPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPVVFAD 310
            :..|:..:..| |.......|||.|.:||......||     |:.:|..|..|.........||.
Frog   243 SGAISGVQRAE-NGPIEWSGELPVTCNLSMGLQTLFT-----PVLANILEADQEKCWGFEQFFAV 301

  Fly   311 LDKILNMNVLTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTGM--DEKELYF-----VLPTSH- 367
            .:.:.|..|:.:|::......:..::....:.|...|:...|.:  ..:||.|     ||....
Frog   302 TNDVFNRIVIHVFSLQQMTPHKIYINTYDKVPDFHDLVYKQTKIPAQNQELLFEGRRLVLEQGRL 366

  Fly   368 -PHKTITPKSTPLQLYVEEWSDTSKDSRKWTKRSNPPV-MLYIFQVKKE---------CDY-KIP 420
             .|..||.:..|:.:...|.  .|....::.:...|.: ..|...|...         |.| :|.
Frog   367 AQHFPITTEENPIFVLTREM--VSVIGLRFDEIVIPKLHSHYDLDVDANMAKAVTGVACYYCRIA 429

  Fly   421 EPILSILS--RKFIANKFKTKERWLQK--------------RVVLDMLY---VLTKEQARYEMLV 466
            ..:|.:|.  ||.|        |||.:              .|.|.:.:   .:.|:...||.|:
Frog   430 ASLLLVLELMRKGI--------RWLSEILKEEYNENVHRNTEVSLKLSFCNRTIEKDLKTYEQLI 486

  Fly   467 S---------------GINERALSLEDEMME------------NSFID---------SIDKQRII 495
            .               .::....||:..:.|            :|:|:         :::|.:::
Frog   487 QTSVEPEVYVIHGKLLNLSSTQESLKSSLQEIKNKLTPGGVLMDSWINAEGTHSADRNVEKLQVL 551

  Fly   496 ISFAYDQLTSLLKEAQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSFLEACL-------REA 553
            :|...:......|:   |...|.|.:..|..|.::. ...|.|.|:...|.:.|:       .:|
Frog   552 LSLITEIYCQFKKD---KAQRRLLYNEEQIHKFDKQ-KMCIHSTKAYSLFKDECVGKYEGFRSKA 612

  Fly   554 KDMVKTTNQLRKEV------C---EKDLFDCARFYKKY 582
            .|.::....:||::      |   |:::..|..:..:|
Frog   613 LDWMRKMIHVRKQLFSLKSQCFEIEEEVSKCQHYINQY 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IKKbeta	NP_524751.3	S_TKc	7..245	CDD:214567	84/250 (34%)
IKKbeta	NP_524751.3	PKc_like	13..316	CDD:304357	102/315 (32%)
tbk1	NP_001135652.1	STKc_TBK1	15..330	CDD:270890	105/338 (31%)
		Ubl_TBK1	308..385	CDD:340647	14/76 (18%)
		TBK1_CCD1	400..651	CDD:408193	46/263 (17%)
		TBK1_C	674..720	CDD:409263
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910