DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbp80 and NCBP1

DIOPT Version :9

Sequence 1:	NP_524750.2	Gene:	Cbp80 / 44409	FlyBaseID:	FBgn0022942	Length:	800	Species:	Drosophila melanogaster
Sequence 2:	NP_002477.1	Gene:	NCBP1 / 4686	HGNCID:	7658	Length:	790	Species:	Homo sapiens

Alignment Length:	800	Identity:	464/800 - (57%)
Similarity:	615/800 - (76%)	Gaps:	10/800 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRRRAHDTEDEGYDHRRNKRRRVSENQEIEDRLESLILRVGERSTSSVESNLEGLVSVLEADLG 65
            |||||..|..|.|..|   |||:.|:..|.||.|||||.:|||:|..|:|||||||..||||||.
Human     1 MSRRRHSDENDGGQPH---KRRKTSDANETEDHLESLICKVGEKSACSLESNLEGLAGVLEADLP 62

  Fly    66 TFRLKILRILSDCAVRMPEKCTVYTTLVGLLNAKNYKFGGEFVDHMVKTFKESLKMCRWDAARYS 130
            .::.||||:|...|..:|||.|:||||||||||:||.||||||:.|::..|||||...::.|.|.
Human    63 NYKSKILRLLCTVARLLPEKLTIYTTLVGLLNARNYNFGGEFVEAMIRQLKESLKANNYNEAVYL 127

  Fly   131 LRFLADLVNCHVISATSLLQLLDTMIDVSNEDTVPQVRRDWFVFAVLSTLPWVGRDLYEKKESAL 195
            :|||:||||||||:|.|::.:.:..:.|:.|:.||||||||:|:|.||:|||||::|||||::.:
Human   128 VRFLSDLVNCHVIAAPSMVAMFENFVSVTQEEDVPQVRRDWYVYAFLSSLPWVGKELYEKKDAEM 192

  Fly   196 ESLLLRIEVYLNKRSKKHHNALRVWSSDAPHPQEEYLDCLWAQIRKLRQDNWAEKHIPRPYLVFD 260
            :.:....|.||.:|.|.|...|:||::|.|||||||||||||||:||::|.|.|:||.||||.||
Human   193 DRIFANTESYLKRRQKTHVPMLQVWTADKPHPQEEYLDCLWAQIQKLKKDRWQERHILRPYLAFD 257

  Fly   261 SILCEALQHNLPTIVPPPHHDNFEYPMPWVVYRMFDYTDCPDGPNLPGAHSIERFLIEEHLHHII 325
            ||||||||||||...||||.::..||||.|::|||||||.|:||.:||:||:|||:|||:||.||
Human   258 SILCEALQHNLPPFTPPPHTEDSVYPMPRVIFRMFDYTDDPEGPVMPGSHSVERFVIEENLHCII 322

  Fly   326 ETYHHERKDCAAQLLSFPYKHKIPLEYCIVEVVFAELFHMPTPRYLDICYGSILIELCKLQPATL 390
            :::..|||.|||||:|:|.|:||||.|.||||:|||||.:|.|.::|:.|.::|||||||||.:|
Human   323 KSHWKERKTCAAQLVSYPGKNKIPLNYHIVEVIFAELFQLPAPPHIDVMYTTLLIELCKLQPGSL 387

  Fly   391 PQVLAQATEILFMRIDSMNTSCFDRFVNWFSYHLSNFKFTWSWDEWDSCLLLDGEHPRPKFIQEV 455
            |||||||||:|:||:|:|||:|.|||:||||:|||||:|.|||::|..||..|.|.|:|||::||
Human   388 PQVLAQATEMLYMRLDTMNTTCVDRFINWFSHHLSNFQFRWSWEDWSDCLSQDPESPKPKFVREV 452

  Fly   456 LQKCLRLSYHQRITEMMPTTYAKLIPLTPVPNYKYANEEAANLPGTTVAHQLVVAIRQKCTPEEV 520
            |:||:||||||||.:::|.|::.|.|..|...|||.:|.:.:|||.:||..|.||.:.|.|.:|:
Human   453 LEKCMRLSYHQRILDIVPPTFSALCPANPTCIYKYGDESSNSLPGHSVALCLAVAFKSKATNDEI 517

  Fly   521 VNILKDIPNSGYSGEEMSDGSFNALKIDVFVQTLLNLGSKSFSHSFAAISKFHSVFRALAETEEA 585
            .:||||:||.....::....|||.|||:|||||||:|.:|||||||:|::|||.||:.|||::|.
Human   518 FSILKDVPNPNQDDDDDEGFSFNPLKIEVFVQTLLHLAAKSFSHSFSALAKFHEVFKTLAESDEG 582

  Fly   586 QICILHNIFELWSSHQQMMVVLIDKLLKLQIVDCSAVATWIFSKEMTGEFTKLYLWEILHLTIKK 650
            ::.:|..:||:|.:|.||:.||:||:::.|||||:|||.||||.|::.:||:|::|||||.||:|
Human   583 KLHVLRVMFEVWRNHPQMIAVLVDKMIRTQIVDCAAVANWIFSSELSRDFTRLFVWEILHSTIRK 647

  Fly   651 MNKHVIKLNTELSEAKEKLAKADSSSSDSEDDSSHKRKKPITHADKPSEEVVERMEEKLEAANVN 715
            |||||:|:..||.|||||||:.....||.:|.||.::       |...||.:||::||:|:|...
Human   648 MNKHVLKIQKELEEAKEKLARQHKRRSDDDDRSSDRK-------DGVLEEQIERLQEKVESAQSE 705

  Fly   716 QKRLFLIVFQRFIMILSEHLLRSDTDGRDPDTDWYRWTIGRLQQVFLMHHEQVQKYSSTLETLLF 780
            ||.|||::||||||||:|||:|.:|||....|.||:..|.||||:||.||:.:|:|..|||.|||
Human   706 QKNLFLVIFQRFIMILTEHLVRCETDGTSVLTPWYKNCIERLQQIFLQHHQIIQQYMVTLENLLF 770

  Fly   781 TSDLDTHILEVFQQFVALRA 800
            |::||.|||.|||||.||:|
Human   771 TAELDPHILAVFQQFCALQA 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbp80	NP_524750.2	MIF4G	31..243	CDD:214713	124/211 (59%)
		MIF4G_like	307..473	CDD:286213	108/165 (65%)
		MIF4G_like_2	494..764	CDD:286214	142/269 (53%)
NCBP1	NP_002477.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		13/27 (48%)
		Nuclear localization signal. /evidence=ECO:0000255	3..20		9/19 (47%)
		MIF4G	28..240	CDD:214713	124/211 (59%)
		MIF4G_like	<351..470	CDD:370287	78/118 (66%)
		MIF4G_like_2	485..760	CDD:401145	148/281 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158924
Domainoid	1	1.000	307	1.000	Domainoid score	I1356
eggNOG	1	0.900	-	-		E1_KOG1104
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1859
Inparanoid	1	1.050	981	1.000	Inparanoid score	I313
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54571
OrthoDB	1	1.010	-	-		D130245at33208
OrthoFinder	1	1.000	-	-		FOG0005276
OrthoInspector	1	1.000	-	-		oto91844
orthoMCL	1	0.900	-	-		OOG6_103433
Panther	1	1.100	-	-	LDO	PTHR12412
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R798
SonicParanoid	1	1.000	-	-		X3789
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800