DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cbp80 and Ncbp1

DIOPT Version :9

Sequence 1:	NP_524750.2	Gene:	Cbp80 / 44409	FlyBaseID:	FBgn0022942	Length:	800	Species:	Drosophila melanogaster
Sequence 2:	NP_001028373.2	Gene:	Ncbp1 / 433702	MGIID:	1891840	Length:	790	Species:	Mus musculus

Alignment Length:	800	Identity:	461/800 - (57%)
Similarity:	612/800 - (76%)	Gaps:	10/800 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRRRAHDTEDEGYDHRRNKRRRVSENQEIEDRLESLILRVGERSTSSVESNLEGLVSVLEADLG 65
            |||||.....|.|..|   |||:.|:..|.||.|||||.:|||:|..|:|||||||..||||||.
Mouse     1 MSRRRHSYENDGGQPH---KRRKTSDANETEDHLESLICKVGEKSACSLESNLEGLAGVLEADLP 62

  Fly    66 TFRLKILRILSDCAVRMPEKCTVYTTLVGLLNAKNYKFGGEFVDHMVKTFKESLKMCRWDAARYS 130
            .::.||||:|...|..:|||.|:||||||||||:||.||||||:.|::..|||||...::.|.|.
Mouse    63 NYKSKILRLLCTVARLLPEKLTIYTTLVGLLNARNYNFGGEFVEAMIRQLKESLKANNYNEAVYL 127

  Fly   131 LRFLADLVNCHVISATSLLQLLDTMIDVSNEDTVPQVRRDWFVFAVLSTLPWVGRDLYEKKESAL 195
            :|||:||||||||:|.|::.:.:..:.|:.|:.||||||||:|:|.||:|||||::|||||::.:
Mouse   128 VRFLSDLVNCHVIAAPSMVAMFENFVSVTQEEDVPQVRRDWYVYAFLSSLPWVGKELYEKKDAEM 192

  Fly   196 ESLLLRIEVYLNKRSKKHHNALRVWSSDAPHPQEEYLDCLWAQIRKLRQDNWAEKHIPRPYLVFD 260
            :.:....|.||.:|.|.|...|:||::|.|||||||||||||||:||::|.|.|:||.||||.||
Mouse   193 DRIFSTTESYLKRRQKTHVPMLQVWTADKPHPQEEYLDCLWAQIQKLKKDRWQERHILRPYLAFD 257

  Fly   261 SILCEALQHNLPTIVPPPHHDNFEYPMPWVVYRMFDYTDCPDGPNLPGAHSIERFLIEEHLHHII 325
            ||||||||||||...||||.::..||||.|::|||||||.|:||.:||:||:|||:|||:||.||
Mouse   258 SILCEALQHNLPPFTPPPHTEDSVYPMPRVIFRMFDYTDDPEGPVMPGSHSVERFVIEENLHCII 322

  Fly   326 ETYHHERKDCAAQLLSFPYKHKIPLEYCIVEVVFAELFHMPTPRYLDICYGSILIELCKLQPATL 390
            ::|..|||.|||||:|:|.|:||||.|.||||:|||||.:|.|.::|:.|.::|||||||||.:|
Mouse   323 KSYWKERKTCAAQLVSYPGKNKIPLNYHIVEVIFAELFQLPAPPHIDVMYTTLLIELCKLQPGSL 387

  Fly   391 PQVLAQATEILFMRIDSMNTSCFDRFVNWFSYHLSNFKFTWSWDEWDSCLLLDGEHPRPKFIQEV 455
            |||||||||:|:||:|:|:|:|.|||:||||:|||||:|.|||::|..||..|.|.|:|||::||
Mouse   388 PQVLAQATEMLYMRLDTMSTTCVDRFINWFSHHLSNFQFRWSWEDWSDCLTQDLESPKPKFVREV 452

  Fly   456 LQKCLRLSYHQRITEMMPTTYAKLIPLTPVPNYKYANEEAANLPGTTVAHQLVVAIRQKCTPEEV 520
            |:||:||||||.|.:::|.|::.|.|..|...|||.:|.:.:|||.:||..|.||.:.|.|.:|:
Mouse   453 LEKCMRLSYHQHILDIVPPTFSALCPANPTCIYKYGDESSNSLPGHSVALCLSVAFKSKATNDEI 517

  Fly   521 VNILKDIPNSGYSGEEMSDGSFNALKIDVFVQTLLNLGSKSFSHSFAAISKFHSVFRALAETEEA 585
            .:||||:||.....::.....||.|||:|||||||:|.:|||||||:|::|||.||:.|||:::.
Mouse   518 FSILKDVPNPNQVDDDDEGFRFNPLKIEVFVQTLLHLAAKSFSHSFSALAKFHEVFKTLAESDKG 582

  Fly   586 QICILHNIFELWSSHQQMMVVLIDKLLKLQIVDCSAVATWIFSKEMTGEFTKLYLWEILHLTIKK 650
            ::.:|..:||:|.:|.||:.||:||:::.|||||:|||.||||.|::.:||:|::|||||.||:|
Mouse   583 KLHVLRVMFEVWRNHPQMIAVLVDKMIRTQIVDCAAVANWIFSSELSRDFTRLFVWEILHSTIRK 647

  Fly   651 MNKHVIKLNTELSEAKEKLAKADSSSSDSEDDSSHKRKKPITHADKPSEEVVERMEEKLEAANVN 715
            |||||:|:..||.|||||||:.....||.:|.||.::       |...||.:||::||:|||...
Mouse   648 MNKHVLKIQKELEEAKEKLARQHKRRSDDDDRSSDRK-------DGALEEQIERLQEKVEAAQSE 705

  Fly   716 QKRLFLIVFQRFIMILSEHLLRSDTDGRDPDTDWYRWTIGRLQQVFLMHHEQVQKYSSTLETLLF 780
            ||.|||::||||||||:|||:|.:|||....|.||:..|.||||:||.||:.:|:|..|||.|||
Mouse   706 QKNLFLVIFQRFIMILTEHLVRCETDGTSILTPWYKNCIERLQQIFLQHHQTIQQYMVTLENLLF 770

  Fly   781 TSDLDTHILEVFQQFVALRA 800
            |::||.|||.|||||.||:|
Mouse   771 TAELDPHILAVFQQFCALQA 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbp80	NP_524750.2	MIF4G	31..243	CDD:214713	124/211 (59%)
		MIF4G_like	307..473	CDD:286213	107/165 (65%)
		MIF4G_like_2	494..764	CDD:286214	141/269 (52%)
Ncbp1	NP_001028373.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		12/27 (44%)
		Nuclear localization signal. /evidence=ECO:0000255	3..20		8/19 (42%)
		MIF4G	28..240	CDD:214713	124/211 (59%)
		MIF4G_like	<351..470	CDD:286213	76/118 (64%)
		MIF4G_like_2	485..759	CDD:312575	147/280 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	666..685		7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849303
Domainoid	1	1.000	306	1.000	Domainoid score	I1354
eggNOG	1	0.900	-	-		E1_KOG1104
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1859
Inparanoid	1	1.050	971	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54571
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005276
OrthoInspector	1	1.000	-	-		oto95423
orthoMCL	1	0.900	-	-		OOG6_103433
Panther	1	1.100	-	-	LDO	PTHR12412
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R798
SonicParanoid	1	1.000	-	-		X3789
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790