DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cbp80 and CG7907

DIOPT Version :9

Sequence 1:	NP_524750.2	Gene:	Cbp80 / 44409	FlyBaseID:	FBgn0022942	Length:	800	Species:	Drosophila melanogaster
Sequence 2:	NP_001097860.1	Gene:	CG7907 / 42539	FlyBaseID:	FBgn0038887	Length:	753	Species:	Drosophila melanogaster

Alignment Length:	844	Identity:	278/844 - (32%)
Similarity:	430/844 - (50%)	Gaps:	141/844 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRRRAHDTEDEGYDHRRNKRRRVSENQEIEDRLESLI--------LRVGERSTSSVESNLEGLV 57
            |.||:..|:.||..|..|.||...:..:.:|..:..|.        |::|         ||..|:
  Fly     1 MGRRKREDSSDEEGDDCRQKRTAETTVKTVEQLMRELSFPGHTPLELKLG---------NLGYLL 56

  Fly    58 SV-LEADLGTFRLKILRILSDCAVRMPEKCTVYTTLVGLLNAKNYKFGGEFVDHMVKTFKESLKM 121
            .. :..||   :..::..|..|....|.:.:.|.|||||:|..:::||.|.:..|.....||:.:
  Fly    57 GKGMSVDL---KENLINELVICLGYYPGQASAYATLVGLINVADFEFGSECLLFMAHKVGESVHI 118

  Fly   122 CRWDAARYSLRFLADLVNCHVISATSLLQLL-------------DTMIDVSNEDTVPQVRRDWFV 173
            ..|:..|..:..:.||.:|.|:.::.:|:||             |.::.|:     ||:|||:..
  Fly   119 RDWNRCRGVVHCMVDLYHCQVLPSSYILKLLAAFLKDCEALKDPDDLVGVT-----PQIRRDFLA 178

  Fly   174 FAVLSTLPWVGRDLYEKKESALESLLLRIEVYLNKRSKKHHNALRVWSSDAPHPQEEYLDCLWAQ 238
            :.|||.:|.:||||  :.|:|.:.|::.:::|:.|||..|.|.|.||..   ..|.:||:.||.|
  Fly   179 YCVLSAMPLIGRDL--EGETAFDKLIVSLQIYIKKRSALHTNMLSVWPD---FNQRDYLELLWQQ 238

  Fly   239 IRKLRQDNWAE-KH--IPRPYLVFDSILCEALQHNLPTIVPPPHHDNFEYPMPWVVYRMFDYTDC 300
            :..:||::||| :|  |||||..|...|.....|.|.......|.:...||:|.|.:|:|.....
  Fly   239 VDGMRQNHWAEPEHQLIPRPYKSFSETLSHGRIHQLRDYDLAAHEERCRYPLPRVCFRIFSCDSV 303

  Fly   301 PDGPNLPGAHSIERFLIEEHLHHIIETYHHERKDCAAQLLSF-PYKHKIPLEYCIVEVVFAELFH 364
            .:.||:|...||||.|:|.|:..|:.::|.|||.||..||.: ..|.::|:.||||||:..|:..
  Fly   304 GEIPNMPPPVSIERHLLEAHILDILISFHKERKICADSLLMYAASKPQLPVYYCIVEVILGEMLR 368

  Fly   365 MPTPRYLDICYGSILIELCKLQPATLPQVLAQATEILFMRIDSMNTSCFDRFVNWFSYHLSNFKF 429
            :||..:..|.|||||:||||.||..:|||:|||.:|::.|::||:.:||||.|||.|:|:|||.|
  Fly   369 LPTANWSTIAYGSILVELCKRQPDKIPQVVAQALDIIYNRLNSMSVACFDRLVNWVSHHISNFGF 433

  Fly   430 TWSWDEWDSCL--LLDGE----HPRPKFIQEVLQKCLRLSYHQRITEMMPTTYAKLIPLTPVPNY 488
            ...|.:|...|  .:|..    .|:..|::|:|:||.||||||||.:::|...|..:|...:|::
  Fly   434 NCQWSKWAQGLPSPIDPSATNLQPKVVFLRELLKKCFRLSYHQRIKDVVPDILADFLPPPVLPHF 498

  Fly   489 KYANEEAANLPGTTVAHQLVVAIRQ-KCTPEEVVNILKDIPNSGYSGEEMSDGSFNALKIDVFVQ 552
            |:.:|   .|||..::..|:.|:|. :.:||.:..|:|.           |.|....|||:||.|
  Fly   499 KFVDE---TLPGAILSKDLLEAMRSPQASPEMISEIIKS-----------STGIGPLLKINVFTQ 549

  Fly   553 TLLNLGSKSFSHSFAAISKFHSVFRAL-AETEEAQICILHNIFELWSSHQQMMVVLIDKLLKLQI 616
            ..|:||||||||:|..:.|:||||:.| |...|.|..:|:.||::|.:..|...|:.:||:...|
  Fly   550 NCLHLGSKSFSHTFGILRKYHSVFKDLVAGDPERQAAVLNGIFDVWVASDQYKFVVTEKLVTGLI 614

  Fly   617 VDCSAVATWIFSKEMTGEFTKLYLWEILHLTIKKMNKHVIKLNTELSEAKEKLAKADSSSSDSED 681
            ::..:|..|||...|..|.||:|:||:||..::           .|...::|:...|
  Fly   615 IEPISVVRWIFGPSMRKELTKIYIWELLHSALR-----------HLKRVQQKIEVVD-------- 660

  Fly   682 DSSHKRKKPITHADKPS--EEVVERMEEKLEAANVNQKRLFLIVFQRFIMIL----------SEH 734
                        .|.||  :.||:.:             ||.|| |||:..|          .||
  Fly   661 ------------VDDPSACDPVVKGI-------------LFTIV-QRFVKTLCGAPFADEGTEEH 699

  Fly   735 LLRSDTDGRDPDTDWYRWTIGRLQQVFLMHHEQVQKYSSTLETLL-FTSDLDTHILEVFQQFVA 797
            .             |::|.:|||::...::.:..:..::.|..:. ..|||...|.:....|||
  Fly   700 Y-------------WFQWVLGRLEETLFIYADDFRVINNKLIKMSEDASDLRPEISKTIAAFVA 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cbp80	NP_524750.2	MIF4G	31..243	CDD:214713	67/233 (29%)
		MIF4G_like	307..473	CDD:286213	81/172 (47%)
		MIF4G_like_2	494..764	CDD:286214	82/283 (29%)
CG7907	NP_001097860.1	MIF4G	27..243	CDD:214713	67/237 (28%)
		MIF4G_like	310..484	CDD:286213	81/173 (47%)
		MIF4G_like_2	502..709	CDD:286214	81/278 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468925
Domainoid	1	1.000	101	1.000	Domainoid score	I2327
eggNOG	1	0.900	-	-		E1_KOG1104
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	292	1.000	Inparanoid score	I821
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54571
OrthoDB	1	1.010	-	-		D130245at33208
OrthoFinder	1	1.000	-	-		FOG0005276
OrthoInspector	1	1.000	-	-		otm3566
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3789
	11	10.910