Protein Alignment MSI1 and Rb97D

DIOPT Version :10

• Sequence 1: NP_002433.1
• Gene: MSI1 / 4440
• HGNCID: 7330
• Length: 362
• Species: Homo sapiens
• Sequence 2: NP_524520.1
• Gene: Rb97D / 43231
• FlyBaseID: FBgn0004903
• Length: 471
• Species: Drosophila melanogaster
• Alignment Length: 401
• Identity: 119/401 - (29%)
• Similarity: 160/401 - (39%)
• Gaps: 104/401 - (25%)

Human    21 KMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHEL 85
            |:|||||:..||:|.|:.::||:|:|.:.:||||..|||||||||:|:.....||:......|.:
  Fly    33 KLFIGGLAPYTTEENLKLFYGQWGKVVDVVVMRDAATKRSRGFGFITYTKSLMVDRAQENRPHII 97

Human    86 DSKTIDPKVAFPRRAQPKMVTR--TKKIFVGGLSVNTTVEDVKQYFEQFGKVDDAMLMFDKTTNR 148
            |.||::.|.|.||..:....|.  .||:|||||..|...|.:::||.|||.|....|:.||||.:
  Fly    98 DGKTVEAKRALPRPERESRETNISVKKLFVGGLKDNHDEECLREYFLQFGNVVSVKLLTDKTTGK 162

Human   149 HRGFGFVTFESEDIVEKVCEIHFHEINNKMVECKKA----QPKEVMSPTGSARGRSRVMP-YGMD 208
            .|||.||.|:..|.|:|......|.|....|:.||:    ..||...|.|.|   :.:.| ....
  Fly   163 RRGFAFVEFDDYDAVDKAILKKQHAIKYVHVDVKKSIYNLDKKEKQQPGGLA---NAIKPSLNQQ 224

Human   209 AFMLGIGMLGYPGFQATTYASRSYTGLAPGYTYQFPEFRVERTPLP----SAPVLPELTAIPLTA 269
            ....|.|.                  ..|....|.|.|   |.|:|    ..|...:....|::|
  Fly   225 QQQQGGGQ------------------QPPNGNMQAPSF---RPPVPPQQAMGPYQQQPPPAPMSA 268

Human   270 -------YGPMAAA------AAAAAVVRGTGSHP------WTMAPPP------------------ 297
                   :||...|      ......:.|.|.:|      |...|||
  Fly   269 PPPNFNYWGPPPPAMPPYYQQPPPQQMNGWGPYPPPQQNGWNAPPPPPPGAQQWHANQWGCPPPV 333

Human   298 ------GSTPSRTGGFLGTTSPGPMA--------ELYGAA---NQDSGVSSYISAASPAPSTGFG 345
                  |:.|..    :|...|.|.|        .:.|||   :|..      |:..|.|...||
  Fly   334 QQVPPVGAVPPP----MGHNGPPPTAPGNWNMPPPVPGAAPPSHQQQ------SSQQPTPQPNFG 388

Human   346 HSL-----GGP 351
            ...     |||
  Fly   389 TGYQQNYGGGP 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MSI1	NP_002433.1	RRM1_MSI	21..96	CDD:409990	35/74 (47%)
		PABP-1234	<32..339	CDD:130689	105/371 (28%)
		RRM2_MSI	110..183	CDD:240769	31/72 (43%)
Rb97D	NP_524520.1	RRM2_hnRNPA_like	124..196	CDD:409766	31/71 (44%)
		RRM_SF	33..110	CDD:473069	36/76 (47%)