Protein Alignment MSI1 and msi

DIOPT Version :10

• Sequence 1: NP_002433.1
• Gene: MSI1 / 4440
• HGNCID: 7330
• Length: 362
• Species: Homo sapiens
• Sequence 2: NP_733108.2
• Gene: msi / 43087
• FlyBaseID: FBgn0011666
• Length: 634
• Species: Drosophila melanogaster
• Alignment Length: 312
• Identity: 134/312 - (42%)
• Similarity: 180/312 - (57%)
• Gaps: 39/312 - (12%)

Human     8 PGLASPDSPHDPC--KMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMD 70
            |.| |..|..||.  |:|:|||||||:.:.|:|||..||.|.:.|:|:||:|:|||||||:||.:
  Fly   190 PSL-SGGSGSDPAPGKLFVGGLSWQTSSDKLKEYFNMFGTVTDVLIMKDPVTQRSRGFGFITFQE 253

Human    71 QAGVDKVLAQSRHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKQYFEQFGKV 135
            ...|:|||....|.||.|.||||.|.|:. :|:...:||||||||:|.:|:.|:||.||.|||.|
  Fly   254 PCTVEKVLKVPIHTLDGKKIDPKHATPKN-RPRQANKTKKIFVGGVSQDTSAEEVKAYFSQFGPV 317

Human   136 DDAMLMFDKTTNRHRGFGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPKEVMSPTGSARGRS 200
            ::.:::.|:.|.|||||||||||:||:|::|||||||.|.||.||||||||||.::|..... :.
  Fly   318 EETVMLMDQQTKRHRGFGFVTFENEDVVDRVCEIHFHTIKNKKVECKKAQPKEAVTPAAQLL-QK 381

Human   201 RVMPYGMDAFMLGIGMLGYPGFQATTYASRSYTGLAPGYTYQFPEFRVER-TPLPSAPVLPELTA 264
            |:             |||..|.|..|...:.......|.....|...::. |.|..:|.
  Fly   382 RI-------------MLGTLGVQLPTAPGQLIGARGAGVATMNPLAMLQNPTQLLQSPA------ 427

Human   265 IPLTAYGPMAAAAAAAAVVRGTGSHPWTM--APPPGSTPSRTG-GFLGTTSP 313
                    .||||..||::   ..:|:.:  |....|..::.| |.|.||.|
  Fly   428 --------AAAAAQQAALI---SQNPFQVQNAAAAASIANQAGFGKLLTTYP 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MSI1	NP_002433.1	RRM1_MSI	21..96	CDD:409990	42/74 (57%)
		PABP-1234	<32..339	CDD:130689	119/286 (42%)
		RRM2_MSI	110..183	CDD:240769	46/72 (64%)
msi	NP_733108.2	RRM_SF	204..278	CDD:473069	42/73 (58%)
		RRM2_MSI	292..365	CDD:240769	46/72 (64%)