Protein Alignment MSI1 and Hrb27C

DIOPT Version :10

• Sequence 1: NP_002433.1
• Gene: MSI1 / 4440
• HGNCID: 7330
• Length: 362
• Species: Homo sapiens
• Sequence 2: NP_476869.1
• Gene: Hrb27C / 33968
• FlyBaseID: FBgn0004838
• Length: 421
• Species: Drosophila melanogaster
• Alignment Length: 419
• Identity: 130/419 - (31%)
• Similarity: 185/419 - (44%)
• Gaps: 91/419 - (21%)

Human    21 KMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHEL 85
            |:|:|||||:||||.|..||.:||::.:|:||::..:.||||||||||.|...|:.||....|.|
  Fly     8 KLFVGGLSWETTQENLSRYFCRFGDIIDCVVMKNNESGRSRGFGFVTFADPTNVNHVLQNGPHTL 72

Human    86 DSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKQYFEQFGKVDDAMLMFDKTTNRHR 150
            |.:|||||...||..|........|:|:|||..|.|..|::.:|.::|||.:.::|:|:...:.|
  Fly    73 DGRTIDPKPCNPRTLQKPKKGGGYKVFLGGLPSNVTETDLRTFFNRYGKVTEVVIMYDQEKKKSR 137

Human   151 GFGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPKEVM-------SPTGSARGR-----SRVM 203
            ||||::||.|..||.|....:..:|.|.||.|||:|::..       |..|.|.|:     |...
  Fly   138 GFGFLSFEEESSVEHVTNERYINLNGKQVEIKKAEPRDGSGGQNSNNSTVGGAYGKLGNECSHWG 202

Human   204 PY--------GMDAFMLG------IG----MLGYPGFQATTYASR-SYTGLAPGYTYQ------- 242
            |:        |.:..|.|      ||    |.||.|:..:....: .|....|| :||
  Fly   203 PHHAPINMMQGQNGQMGGPPLNMPIGAPNMMPGYQGWGTSPQQQQYGYGNSGPG-SYQGWGAPPG 266

Human   243 ----------------------FPEFRVERTPLPSAPV---------LPELTAIPLTAYGPMAAA 276
                                  :..:....|..||.|.         :|..:|.|..|.|    |
  Fly   267 PQGPPPQWSNYAGPQQTQGYGGYDMYNSTSTGAPSGPSGGGSWNSWNMPPNSAGPTGAPG----A 327

Human   277 AAAAAVVRGTGSHPWTMAPPPGSTPSRTGGFLGTTSPGPMAELYGA--------ANQDSGVSSYI 333
            .|..|....:.:..|....|  ||....|| :..|.||..|...|:        :..|...|:|:
  Fly   328 GAGTATDMYSRAQAWATGGP--STTGPVGG-MPRTGPGNSASKSGSEYDYGGYGSGYDYDYSNYV 389

Human   334 -----SAASPAPSTGFGH-SLGGPLIATA 356
                 |.....|.:.:|: |...|..||:
  Fly   390 KQEGASNYGAGPRSAYGNDSSTQPPYATS 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MSI1	NP_002433.1	RRM1_MSI	21..96	CDD:409990	41/74 (55%)
		PABP-1234	<32..339	CDD:130689	116/388 (30%)
		RRM2_MSI	110..183	CDD:240769	29/72 (40%)
Hrb27C	NP_476869.1	RRM1_hnRNPA_hnRNPD_like	9..80	CDD:409763	38/70 (54%)
		RRM2_DAZAP1	94..173	CDD:409765	32/78 (41%)