DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MSI1 and SPBC660.15

DIOPT Version :9

Sequence 1:	NP_002433.1	Gene:	MSI1 / 4440	HGNCID:	7330	Length:	362	Species:	Homo sapiens
Sequence 2:	NP_595094.1	Gene:	SPBC660.15 / 2541150	PomBaseID:	SPBC660.15	Length:	474	Species:	Schizosaccharomyces pombe

Alignment Length:	362	Identity:	131/362 - (36%)
Similarity:	176/362 - (48%)	Gaps:	53/362 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     1 METDAPQPGLASPDSPHDPCKMFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGF 65
            ||::.......||.:..|. |||||||:|:||.:.||:||.|||||.:|.||||..|.|||||||
pombe   145 MESNEDNAEETSPFNREDG-KMFIGGLNWETTDDSLRDYFEQFGEVLDCTVMRDSTTGRSRGFGF 208

Human    66 VTFMDQAGVDKVLAQSRHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKQYFE 130
            :||.:...|::|::: .|.||.|.||||.|.||..|.|    |.|:||||:..:.|.|:.:.:|.
pombe   209 LTFKNPKCVNEVMSK-EHHLDGKIIDPKRAIPREEQEK----TAKMFVGGVPGDCTEEEFRNFFN 268

Human   131 QFGKVDDAMLMFDKTTNRHRGFGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPKEVMSPTGS 195
            |||:|.||.||.||.|.|.|||||||:|:|..||......:..|:.|.||.|:|.||..:..:..
pombe   269 QFGRVLDATLMMDKDTGRPRGFGFVTYENESAVEATMSQPYITIHGKPVEVKRATPKASLRDSHD 333

Human   196 ARGRSRVMPYGMDAFMLGIGMLGYPGFQATTYAS--RSYTGLAPG----YTYQFPEFRVERTPLP 254
            ....                  ||.|.....||.  ..|.|:.|.    |..|..::......:|
pombe   334 RHQH------------------GYHGNANPYYAQNMNMYGGMTPAMMAQYYRQMQQYMEAMRNMP 380

Human   255 SA--------PVLPELTAIPLTAYGPMAAAAAAAAVVRGTGSH-PWTMAPPPGSTPSRTGGFLGT 310
            :|        ||:|...|.........||....:.:.:|||.. |::.:.|.||:   .||:.|.
pombe   381 AAAGAVPYPQPVMPAGMADWQQQQQQGAAYFDPSKMNQGTGDGVPFSPSMPSGSS---RGGYHGR 442

Human   311 TSPGPMAELYGAANQDSGVSSYISAASPAPSTGFGHS 347
            ...||..:.|.......|           .:||.|||
pombe   443 NPGGPNRQRYRGRRDGRG-----------GNTGGGHS 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MSI1	NP_002433.1	RRM1_MSI	21..96	CDD:409990	44/74 (59%)
		PABP-1234	<32..339	CDD:130689	112/321 (35%)
		RRM2_MSI	110..183	CDD:240769	35/72 (49%)
SPBC660.15	NP_595094.1	RRM1_Hrp1p	165..240	CDD:241021	44/75 (59%)
SPBC660.15	NP_595094.1	RRM2_Hrp1p	248..322	CDD:240776	36/73 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	66	1.000	Domainoid score	I3150
eggNOG	1	0.900	-	-		E1_KOG4205
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	190	1.000	Inparanoid score	I1231
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000417
OrthoInspector	1	1.000	-	-		otm53392
orthoMCL	1	0.900	-	-		OOG6_101082
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1869
SonicParanoid	1	1.000	-	-		X310
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.790