DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nnp-1 and Rrp1

DIOPT Version :9

Sequence 1:	NP_651976.1	Gene:	Nnp-1 / 44391	FlyBaseID:	FBgn0022069	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_001012073.1	Gene:	Rrp1 / 309674	RGDID:	1307286	Length:	443	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	137/529 - (25%)
Similarity:	219/529 - (41%)	Gaps:	135/529 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 EVKIIRALACNDVVERNRQIRILRKWFKARA-GSSFPFNEDDFMRIWKGLYYTMWMSDKPLVQEE 103
            |:::.:.||.|:.|.|:|.:|.|:|:..||: .::..|..::.:::||||:|.|||.||||.||:
  Rat    10 EIQLAQRLAGNEQVTRDRALRKLQKYIVARSQRATGGFTPEELLKVWKGLFYCMWMQDKPLQQED 74

  Fly   104 LAEKLAQMVDSFGGNTACSLAYFSAFMRTMCQEYFGIDQWRMDKFLMLTRRMVRYLLRFLKQNNW 168
            |...:||:|.:| ..|.....:..||.:||.:|:.|||:.|:|||.||.|.::...|:.:|...|
  Rat    75 LGRTIAQLVHAF-QTTESQHLFLRAFWQTMIREWVGIDRLRLDKFYMLMRMVLSESLKAVKTGGW 138

  Fly   169 NADLIAAFNSSMQLSVMSEQPKS-RGMTMHYLDVFFEELAKAANGEITAAQVNMFLRPFVTYIAT 232
            ....|......:...::|...:: .|:..|:|::|.|||.|....|:||.|...|::||....|.
  Rat   139 EERQIEQLLQLLTTEILSPDSQAPNGVKSHFLEIFLEELTKVGAAELTADQNLQFIKPFCQIAAR 203

  Fly   233 QRDAKLVAQCRTRVLYHLMYQSDLGRQYSEKYNAWKQMGFPTASIDDIEKLDS------GFDEED 291
            .:|:.::.:....:...::.|:                  |.|..|.:.:||:      |.||:|
  Rat   204 TKDSLVLHKITQSIFEAIVEQA------------------PLAIEDLMNELDAQSGEGEGSDEDD 250

  Fly   292 -----DEVNAEEE--QPRATSLDPRAGNV---DVHM------------PELPLNADCVLDELQTQ 334
                 ||.:.:|:  |..|....| ||:|   |:.:            |.|..:.:.|.::|...
  Rat   251 GDDDSDEASEDEQDLQDTAPKNQP-AGSVSRADLEVDEEAWDDEEDTGPVLQFDYEAVANKLFKL 314

  Fly   335 LRTNDFNSKRRKGLRKLIQIFETYQRGEFPLGVRTMPKVEGQTLSEMVEQKVAALDKMEDEVFAT 399
            .......|:.||.|.|:||.......|.||                            ||:|  .
  Rat   315 ASRQSTPSQNRKRLYKVIQKLRDLAGGIFP----------------------------EDDV--P 349

  Fly   400 GRKLKKL------NKSKRKRL--LQSINFEEVDEHNYDEVISKALPPELQKKVNYNAKVRSSINN 456
            .:..|||      .|.|:|||  ||..|.|...|
  Rat   350 EKAYKKLLEGRRKQKKKKKRLPTLQPQNKEGGSE------------------------------- 383

  Fly   457 AWVVEEVKEAEPKSKKAKKEEPPQQNKDDQTKVKKKSQLKPKNDQSKPKIEDQPTLKAEKEEPAK 521
                .|...|:|...:.:|    :..|.|:    |..|..|...:.||...    .|..:.:..|
  Rat   384 ----TEASSADPSRGRKRK----RSRKTDE----KAGQRGPPGKRRKPGAR----AKGPRVQQPK 432

  Fly   522 RKKLDHSKT 530
            |||...|::
  Rat   433 RKKKGSSQS 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nnp-1	NP_651976.1	Nop52	41..247	CDD:283618	69/207 (33%)
Rrp1	NP_001012073.1	Nop52	11..219	CDD:283618	69/208 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353425
Domainoid	1	1.000	129	1.000	Domainoid score	I5117
eggNOG	1	0.900	-	-		E1_KOG3911
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I4535
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1337189at2759
OrthoFinder	1	1.000	-	-		FOG0003215
OrthoInspector	1	1.000	-	-		otm45914
orthoMCL	1	0.900	-	-		OOG6_102179
Panther	1	1.100	-	-	O	PTHR13026
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2173
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760