DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nnp-1 and RRP1B

DIOPT Version :9

Sequence 1:	NP_651976.1	Gene:	Nnp-1 / 44391	FlyBaseID:	FBgn0022069	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_055871.1	Gene:	RRP1B / 23076	HGNCID:	23818	Length:	758	Species:	Homo sapiens

Alignment Length:	778	Identity:	177/778 - (22%)
Similarity:	285/778 - (36%)	Gaps:	260/778 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 EVKIIRALACNDVVERNRQIRILRKWFKARA-GSSFPFNEDDFMRIWKGLYYTMWMSDKPLVQEE 103
            |::..:.||.::...|:|.::.||::...:. ..:..|::::.::|||||:|.||:.|:||:|||
Human     9 EIQFAQRLASSEKGIRDRAVKKLRQYISVKTQRETGGFSQEELLKIWKGLFYCMWVQDEPLLQEE 73

  Fly   104 LAEKLAQMVDSFGGNTACSLAYFSAFMRTMCQEYFGIDQWRMDKFLMLTRRMVRYLLRFLKQNNW 168
            ||..:||:|.:. .|:|....:...|.:||.:|:.|||:.|:||:.||.|.::|.....||:|.|
Human    74 LANTIAQLVHAV-NNSAAQHLFIQTFWQTMNREWKGIDRLRLDKYYMLIRLVLRQSFEVLKRNGW 137

  Fly   169 NADLIAAFNSSMQLSVMSEQPKS-RGMTMHYLDVFFEELAKAANGEITAAQVNMFLRPFVTYIAT 232
            ....|..|...:...|:..:.:| .|:..|::|::.:||:|....|:.|.|...|:.||....|.
Human   138 EESRIKVFLDVLMKEVLCPESQSPNGVRFHFIDIYLDELSKVGGKELLADQNLKFIDPFCKIAAK 202

  Fly   233 QRDAKLVAQCRTRVLYHLMYQSDLGRQYSEKYNAWKQMGFPTASIDDIEKLDSGFDEEDDEVNAE 297
            .:|..||......|...::.||..               .|..:::: :|...|    |.:::||
Human   203 TKDHTLVQTIARGVFEAIVDQSPF---------------VPEETMEE-QKTKVG----DGDLSAE 247

  Fly   298 EEQPRATSL----------------------DPR----AGNVDVHMPELPLNADCVLD---ELQT 333
            |......||                      |.|    .|..:...|.|..:...|.|   |:.:
Human   248 EIPENEVSLRRAVSKKKTALGKNHSRKDGLSDERGRDDCGTFEDTGPLLQFDYKAVADRLLEMTS 312

  Fly   334 QLRTNDFNSKRRKGLRKLIQIFETYQRGEFPLGVRTMPKVEGQTLSEMVEQKVAALDKMEDEVFA 398
            :..|..||.||   |.|||:.|:...              ||.::|::...:..:.|: :|::.:
Human   313 RKNTPHFNRKR---LSKLIKKFQDLS--------------EGSSISQLSFAEDISADE-DDQILS 359

  Fly   399 TGRKLKKLNKSKRKRLLQSINFEEVDEHNYDEVISKALPPELQKKVNYNAKVRSSINNAWVVEEV 463
            .|:..||.||     ||:..|.|                           |.:.|  ..:.|||
Human   360 QGKHKKKGNK-----LLEKTNLE---------------------------KEKGS--RVFCVEE- 389

  Fly   464 KEAEPKSKKAKKEEPPQQNKDDQTKVKKKSQLKPKN----------DQSK---PKIEDQPTLKAE 515
            :::|...:|.::            |.|||..|:|:|          :|::   |:......|||.
Human   390 EDSESSLQKRRR------------KKKKKHHLQPENPGPGGAAPSLEQNRGREPEASGLKALKAR 442

  Fly   516 KEEPAKRKKLD---------------HSKTKEEQSK---------------PKTDEQPKPTPKVE 550
            ..||.......               |:|.|..:.|               |:...|..|:....
Human   443 VAEPGAEATSSTGEESGSEHPPAVPMHNKRKRPRKKSPRAHREMLESAVLPPEDMSQSGPSGSHP 507

  Fly   551 GQSKAKPT------PKTKAAGVDDDAPTNG-------W---------DAPLEDGEQDIFVPS-RK 592
            ...:..||      .:.:..||   .|.||       |         ..|.|.......:|. |:
Human   508 QGPRGSPTGGAQLLKRKRKLGV---VPVNGSGLSTPAWPPLQQEGPPTGPAEGANSHTTLPQRRR 569

  Fly   593 LQVKQA---------------------------------NSKL------PQ---------STPKQ 609
            ||.|:|                                 |..|      ||         |..||
Human   570 LQKKKAGPGSLELCGLPSQKTASLKKRKKMRVMSNLVEHNGVLESEAGQPQALGSSGTCSSLKKQ 634

  Fly   610 PARAE-----FATPQTGSGKHVRIVTKSNCIYPKSDYYRQLKLS-----PQVPYDANRLPGKS 662
            ..|||     |.||                ..||..::|:.|.|     |......|:.|..|
Human   635 KLRAESDFVKFDTP----------------FLPKPLFFRRAKSSTATHPPGPAVQLNKTPSSS 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nnp-1	NP_651976.1	Nop52	41..247	CDD:283618	66/207 (32%)
RRP1B	NP_055871.1	Nop52	10..218	CDD:283618	67/208 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..285		2/25 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..598		43/234 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..681		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	707..758
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159389
Domainoid	1	1.000	131	1.000	Domainoid score	I5148
eggNOG	1	0.900	-	-		E1_KOG3911
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	139	1.000	Inparanoid score	I4510
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1337189at2759
OrthoFinder	1	1.000	-	-		FOG0003215
OrthoInspector	1	1.000	-	-		otm41777
orthoMCL	1	0.900	-	-		OOG6_102179
Panther	1	1.100	-	-	LDO	PTHR13026
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2267
SonicParanoid	1	1.000	-	-		X2173
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790