DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sr-CIII and MEP1B

DIOPT Version :9

Sequence 1:	NP_524747.1	Gene:	Sr-CIII / 44382	FlyBaseID:	FBgn0020376	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_005916.2	Gene:	MEP1B / 4225	HGNCID:	7020	Length:	701	Species:	Homo sapiens

Alignment Length:	211	Identity:	56/211 - (26%)
Similarity:	84/211 - (39%)	Gaps:	51/211 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 KLGTCQLANSVGDHSCDFEREDMCGWRASKAIPQPWKRISAAADFLKEKCLQQDHTFQSDVEG-- 190
            :|..|..:.|..| ||.||.|::||...|......|:|:|..     .:..:.||:.....:|
Human   251 QLYNCSSSLSFMD-SCSFELENVCGMIQSSGDNADWQRVSQV-----PRGPESDHSNMGQCQGSG 309

  Fly   191 ---HFIRLQSQVHA-----SRTYHFISPIYPRNLTVGHSLWFQFELFMFGSEVRNLTISVKPSSM 247
               ||......|.|     |||      :||:.   |... .||.|:..|||...|.|.::..|.
Human   310 FFMHFDSSSVNVGATAVLESRT------LYPKR---GFQC-LQFYLYNSGSESDQLNIYIREYSA 364

  Fly   248 AVEDMWNSFRNICTKLTV--------SGDQGPNWKSQSISIDEMESDFQVVFTVVDPSSLH-GDI 303
                     .|:...||:        :|    :|:...::: ::...|:|||.....|... |.:
Human   365 ---------DNVDGNLTLVEEIKEIPTG----SWQLYHVTL-KVTKKFRVVFEGRKGSGASLGGL 415

  Fly   304 GIDDVKFIKSETNEPH 319
            .|||:..  |||..||
Human   416 SIDDINL--SETRCPH 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sr-CIII	NP_524747.1	CCP	27..>62	CDD:153056
		MAM	143..310	CDD:279023	46/185 (25%)
		MAM	143..310	CDD:99706	46/185 (25%)
MEP1B	NP_005916.2	ZnMc_meprin	26..255	CDD:239809	1/3 (33%)
		Astacin	69..257	CDD:279708	2/5 (40%)
		MAM	260..427	CDD:214533	52/198 (26%)
		MAM	265..427	CDD:99706	49/192 (26%)
		MATH	427..586	CDD:295307	2/3 (67%)
		Required for proteolytic processing	595..607
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910