DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sr-CIII and Sr-CI

DIOPT Version :9

Sequence 1:	NP_524747.1	Gene:	Sr-CIII / 44382	FlyBaseID:	FBgn0020376	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_001285599.1	Gene:	Sr-CI / 33621	FlyBaseID:	FBgn0014033	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	327	Identity:	133/327 - (40%)
Similarity:	187/327 - (57%)	Gaps:	20/327 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VEILWALRLFMIYMVIQSIASCEPDILLRNGKVTELSSWLLGDSIKFECNPGFSLQGKTWHL--- 67
            :|..|.|.:.:||.:......||..|.|.||.:    ::...:.::|.||.|::|||.....
  Fly     1 MEFFWTLAVIVIYCIGHIHGRCERSIDLDNGSI----NYRQRNVVRFRCNRGYTLQGTVMQTCDR 61

  Fly    68 -GNGNMMKRYCAKAGCNDIEKQANGTILTATDGLKAEIECDDEFVLSGNSFTYCNGTKWIIKLGT 131
             |.....|.:||..||...|...||.:...:  |:|::.|.|.:||.|....||:|.:|..:||:
  Fly    62 DGRLRGEKPFCASRGCARPEDPENGHVENLS--LRADVVCHDGYVLVGGRTAYCDGERWSTQLGS 124

  Fly   132 CQLANSVGDHSCDFEREDMCGWRASKAIPQPWKRISAAADFLKEKC-LQQDHTFQSDVEGHFIRL 195
            |:.:|...|||||||.||.|||.|.....:||||:|..:|....:. .:.||||:::..||::|:
  Fly   125 CRRSNHTRDHSCDFESEDQCGWEAETTFRRPWKRVSTVSDIHSLRTGPRHDHTFKNESGGHYMRM 189

  Fly   196 QSQVHASRTYHFISPIYPRNLTVGHSLWFQFELFMFGSEVRNLTISVKPSSMAVEDMWNSFRNIC 260
            ::|:.|..:||.:||||||:||:..:..|:|..||||:.|.||.:||||.||.:..|||.||..|
  Fly   190 ETQMGAYGSYHLLSPIYPRSLTLKTACCFRFHYFMFGAGVDNLVVSVKPVSMPMATMWNRFRANC 254

  Fly   261 TKLTVSGDQGPNWKSQSISIDEMESDFQVVFTVVDPSSLHGDIGIDDVKFIK---------SETN 316
            :|..:||.||..|...:||||||:.||||:||..|..|..|||.|||||.:.         |.|.
  Fly   255 SKFEISGQQGTQWLEHTISIDEMQEDFQVIFTATDARSQFGDIAIDDVKLMTGSECGTNGFSTTT 319

  Fly   317 EP 318
            ||
  Fly   320 EP 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sr-CIII	NP_524747.1	CCP	27..>62	CDD:153056	11/34 (32%)
		MAM	143..310	CDD:279023	83/167 (50%)
		MAM	143..310	CDD:99706	83/167 (50%)
Sr-CI	NP_001285599.1	CCP	22..72	CDD:214478	15/53 (28%)
		CCP	77..125	CDD:214478	17/49 (35%)
		MAM	131..308	CDD:214533	87/176 (49%)
		MAM	136..308	CDD:99706	84/171 (49%)
		Somatomedin_B	335..385	CDD:295334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470083
Domainoid	1	1.000	66	1.000	Domainoid score	I9895
eggNOG	1	0.900	-	-		E1_2CMY0
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006092
OrthoInspector	1	1.000	-	-		mtm9576
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23282
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.840