DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sr-CIII and Sr-CIV

DIOPT Version :9

Sequence 1:	NP_524747.1	Gene:	Sr-CIII / 44382	FlyBaseID:	FBgn0020376	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_608789.1	Gene:	Sr-CIV / 33576	FlyBaseID:	FBgn0031547	Length:	406	Species:	Drosophila melanogaster

Alignment Length:	316	Identity:	128/316 - (40%)
Similarity:	186/316 - (58%)	Gaps:	23/316 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ILWALRLFMIYMVIQSIASCEPDILLRNGKVTELSSWLLGDSIKFECNPGFSLQGK---TWHLGN 69
            :|||  :.:|..|.::.|.|...:.|.:|     |:.::..||.|.|:.|:.|||.   |...|.
  Fly     3 LLWA--IVLISSVDRTNARCLESVHLEHG-----STEIVNGSIIFHCDQGYFLQGSKVFTCDRGI 60

  Fly    70 GNMMKRYCAKAGCNDIEKQANGTILTATDGLKAEIECDDEFVLSGNSFTYCNGTKWIIKLGTCQL 134
            ....|.:|||:||.:.|:..||.:|.|.  :||:|.|.|...|.||...||:|.||..:||:|.|
  Fly    61 PRGKKPFCAKSGCQEYEQIQNGFVLNAP--MKAKIICSDGHGLVGNRIAYCDGEKWSTQLGSCAL 123

  Fly   135 ANSVGDHSCDFEREDMCGWRASKAIPQPWKRISAAADFLKEKC-LQQDHTFQSDVEGHFIRLQSQ 198
            .....|.|||||.||||||.|..:....|||:|..|||..||. .|:|||||:...||::|::::
  Fly   124 RRQTIDVSCDFESEDMCGWTAELSFLGTWKRVSTVADFHSEKTGPQKDHTFQNQSIGHYVRMETE 188

  Fly   199 VHASRTYHFISPIYPRNLTVGHSLWFQFELFMFGSEVRNLTISVKPSSMAVEDMWNS-----FRN 258
            ..|..||||:||:||:.|::..:. |||..|||||.|.:|.:|:||.|:.:.|::.:     |
  Fly   189 SDAFGTYHFLSPLYPKELSLSGAC-FQFHYFMFGSGVGSLLVSIKPVSVTIGDIFKTNHPYKF-- 250

  Fly   259 ICTKLTVSGDQGPNWKSQSISIDEMESDFQVVFTVVDPSSLHGDIGIDDVKFIKSE 314
              .:..::|.||..|...:|.|::|:.||||:||..|..|.:|||.|||||.:.::
  Fly   251 --DQFVMTGSQGARWLEHTIDINKMDEDFQVIFTATDARSQYGDIAIDDVKLMAAK 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sr-CIII	NP_524747.1	CCP	27..>62	CDD:153056	10/34 (29%)
		MAM	143..310	CDD:279023	77/172 (45%)
		MAM	143..310	CDD:99706	77/172 (45%)
Sr-CIV	NP_608789.1	MAM	132..306	CDD:279023	78/178 (44%)
		MAM	132..301	CDD:99706	78/173 (45%)
		Somatomedin_B	336..376	CDD:279385
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470081
Domainoid	1	1.000	66	1.000	Domainoid score	I9895
eggNOG	1	0.900	-	-		E1_2CMY0
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006092
OrthoInspector	1	1.000	-	-		mtm9576
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23282
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.840