Protein Alignment Rab18 and RAB6C

DIOPT Version :10

• Sequence 1: NP_524744.2
• Gene: Rab18 / 44360
• FlyBaseID: FBgn0015794
• Length: 197
• Species: Drosophila melanogaster
• Sequence 2: NP_115520.2
• Gene: RAB6C / 84084
• HGNCID: 16525
• Length: 254
• Species: Homo sapiens
• Alignment Length: 199
• Identity: 70/199 - (35%)
• Similarity: 107/199 - (53%)
• Gaps: 7/199 - (3%)

  Fly     4 RAIKLLVIGESGVGKSSLIRRFVENKFDQNHDVTIGMDFKSKVMQVDGIDYKVALWDTAGAERFR 68
            |..||:.:||..|.|:|||.||..:.||..:...||:||.||.|.::.....:.||||||.||.|
Human    12 RKFKLVFLGEQSVAKTSLITRFRYDSFDNTYQAIIGIDFLSKTMYLEDGTIGLRLWDTAGQERLR 76

  Fly    69 SLTPSFYRKALGAILVYDITSRDSLVKLETWLAELDSYSDNPNIAIIVVGNKID--EERVVDREE 131
            ||.|.:.|.:..|::|||||:.:|..:...|:.::.: ....::.|.:|||:.|  ::|.|..||
Human    77 SLIPRYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRT-ERGSDVIITLVGNRTDLADKRQVSVEE 140

  Fly   132 GRKFARKHRALFIETSAKCDQFVSDVFKDVVEKIVSSEYFNNGNASAGLDIASDRDLEASAS--- 193
            |.:.|:.....||||.||....|..:|:.|...:...|...:|:.....||..::..|.:.|
Human   141 GERKAKGLNVTFIETRAKAGYNVKQLFRRVAAALPGMESTQDGSREDMSDIKLEKPQEQTVSEGG 205

  Fly   194 -TCY 196
             :||
Human   206 CSCY 209

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab18	NP_524744.2	Rab18	6..165	CDD:206656	61/160 (38%)
RAB6C	NP_115520.2	Required for centrosome localization	1..174		62/162 (38%)
		Rab6	14..174	CDD:206654	61/160 (38%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P20340	32..50		6/17 (35%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P20340	69..88		10/18 (56%)