Protein Alignment Rab18 and RAB6A

DIOPT Version :10

• Sequence 1: NP_524744.2
• Gene: Rab18 / 44360
• FlyBaseID: FBgn0015794
• Length: 197
• Species: Drosophila melanogaster
• Sequence 2: NP_002860.2
• Gene: RAB6A / 5870
• HGNCID: 9786
• Length: 208
• Species: Homo sapiens
• Alignment Length: 198
• Identity: 75/198 - (37%)
• Similarity: 115/198 - (58%)
• Gaps: 5/198 - (2%)

  Fly     4 RAIKLLVIGESGVGKSSLIRRFVENKFDQNHDVTIGMDFKSKVMQVDGIDYKVALWDTAGAERFR 68
            |..||:.:||..|||:|||.||:.:.||..:..|||:||.||.|.::....::.||||||.||||
Human    12 RKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTIRLQLWDTAGQERFR 76

  Fly    69 SLTPSFYRKALGAILVYDITSRDSLVKLETWLAELDSYSDNPNIAIIVVGNKID--EERVVDREE 131
            ||.||:.|.:..|::|||||:.:|..:...|:.::.: ....::.|::||||.|  ::|.|..||
Human    77 SLIPSYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRT-ERGSDVIIMLVGNKTDLADKRQVSIEE 140

  Fly   132 GRKFARKHRALFIETSAKCDQFVSDVFKDVVEKIVSSEYFNNGNASAGLDIASDRDLE--ASAST 194
            |.:.|::...:|||||||....|..:|:.|...:...|...:.:....:||..::..|  .|...
Human   141 GERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGG 205

  Fly   195 CYC 197
            |.|
Human   206 CSC 208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab18	NP_524744.2	Rab18	6..165	CDD:206656	67/160 (42%)
RAB6A	NP_002860.2	Rab6	14..174	CDD:206654	67/160 (42%)
		Switch 1. /evidence=ECO:0000269|PubMed:19141279, ECO:0007744|PDB:3CWZ	32..50		7/17 (41%)
		Switch 2. /evidence=ECO:0000269|PubMed:19141279, ECO:0007744|PDB:3CWZ	69..88		12/18 (67%)