Protein Alignment Rab18 and RAB5A

DIOPT Version :10

• Sequence 1: NP_524744.2
• Gene: Rab18 / 44360
• FlyBaseID: FBgn0015794
• Length: 197
• Species: Drosophila melanogaster
• Sequence 2: NP_004153.2
• Gene: RAB5A / 5868
• HGNCID: 9783
• Length: 215
• Species: Homo sapiens
• Alignment Length: 181
• Identity: 75/181 - (41%)
• Similarity: 114/181 - (62%)
• Gaps: 6/181 - (3%)

  Fly     7 KLLVIGESGVGKSSLIRRFVENKFDQNHDVTIGMDFKSKVMQVDGIDYKVALWDTAGAERFRSLT 71
            ||:::|||.||||||:.|||:.:|.:..:.|||..|.::.:.:|....|..:|||||.||:.||.
Human    22 KLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLA 86

  Fly    72 PSFYRKALGAILVYDITSRDSLVKLETWLAELDSYSDNPNIAIIVVGNKID--EERVVDREEGRK 134
            |.:||.|..||:|||||:.:|..:.:.|:.||...: :|||.|.:.|||.|  .:|.||.:|.:.
Human    87 PMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQA-SPNIVIALSGNKADLANKRAVDFQEAQS 150

  Fly   135 FARKHRALFIETSAKCDQFVSDVFKDVVEKIVSSEYFNNGNASA---GLDI 182
            :|..:..||:|||||....|:::|..:.:|:..:|..|.|..||   |:|:
Human   151 YADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDL 201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab18	NP_524744.2	Rab18	6..165	CDD:206656	67/159 (42%)
RAB5A	NP_004153.2	Rab5_related	20..182	CDD:206653	68/160 (43%)
		Switch 1. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	44..56		4/11 (36%)
		Switch 2. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	77..93		9/15 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..215		7/21 (33%)