Protein Alignment Rab18 and RAB4A

DIOPT Version :10

• Sequence 1: NP_524744.2
• Gene: Rab18 / 44360
• FlyBaseID: FBgn0015794
• Length: 197
• Species: Drosophila melanogaster
• Sequence 2: NP_004569.2
• Gene: RAB4A / 5867
• HGNCID: 9781
• Length: 218
• Species: Homo sapiens
• Alignment Length: 212
• Identity: 88/212 - (41%)
• Similarity: 124/212 - (58%)
• Gaps: 21/212 - (9%)

  Fly     3 DRAIKLLVIGESGVGKSSLIRRFVENKF--DQNHDVTIGMDFKSKVMQVDGIDYKVALWDTAGAE 65
            |...|.||||.:|.|||.|:.:|:|.||  |.||  |||::|.||::.|.|...|:.:|||||.|
Human    11 DFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNH--TIGVEFGSKIINVGGKYVKLQIWDTAGQE 73

  Fly    66 RFRSLTPSFYRKALGAILVYDITSRDSLVKLETWLAELDSYSDNPNIAIIVVGNK--IDEERVVD 128
            ||||:|.|:||.|.||:||||||||::...|..||.:....: :.||.||:.|||  :|.:|.|.
Human    74 RFRSVTRSYYRGAAGALLVYDITSRETYNALTNWLTDARMLA-SQNIVIILCGNKKDLDADREVT 137

  Fly   129 REEGRKFARKHRALFIETSAKCDQFVSDVF----KDVVEKIVSSEY--------FNNGNASAGLD 181
            ..|..:||:::..:|:||||...:.|.:.|    :.::.||.|.|.        ...|:| |...
Human   138 FLEASRFAQENELMFLETSALTGENVEEAFVQCARKILNKIESGELDPERMGSGIQYGDA-ALRQ 201

  Fly   182 IASDRDLEA-SASTCYC 197
            :.|.|..:| :|..|.|
Human   202 LRSPRRAQAPNAQECGC 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab18	NP_524744.2	Rab18	6..165	CDD:206656	74/166 (45%)
RAB4A	NP_004569.2	Rab4	14..174	CDD:206696	74/162 (46%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P61106	44..49		4/6 (67%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P61106	70..79		7/8 (88%)