Protein Alignment Rab18 and RAB2A

DIOPT Version :10

• Sequence 1: NP_524744.2
• Gene: Rab18 / 44360
• FlyBaseID: FBgn0015794
• Length: 197
• Species: Drosophila melanogaster
• Sequence 2: NP_002856.1
• Gene: RAB2A / 5862
• HGNCID: 9763
• Length: 212
• Species: Homo sapiens
• Alignment Length: 182
• Identity: 82/182 - (45%)
• Similarity: 120/182 - (65%)
• Gaps: 8/182 - (4%)

  Fly     7 KLLVIGESGVGKSSLIRRFVENKFDQNHDVTIGMDFKSKVMQVDGIDYKVALWDTAGAERFRSLT 71
            |.::||::|||||.|:.:|.:.:|...||:|||::|.::::.:||...|:.:|||||.|.|||:|
Human     8 KYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSIT 72

  Fly    72 PSFYRKALGAILVYDITSRDSLVKLETWLAELDSYSDNPNIAIIVVGNKIDEE--RVVDREEGRK 134
            .|:||.|.||:||||||.||:...|.|||.:...:| |.|:.|:::|||.|.|  |.|.:|||..
Human    73 RSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHS-NSNMVIMLIGNKSDLESRREVKKEEGEA 136

  Fly   135 FARKHRALFIETSAKCDQFVSDVF----KDVVEKIVSSEYFNNGNASAGLDI 182
            |||:|..:|:|||||....|.:.|    |::.||| ....|:..|.:.|:.|
Human   137 FAREHGLIFMETSAKTASNVEEAFINTAKEIYEKI-QEGVFDINNEANGIKI 187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab18	NP_524744.2	Rab18	6..165	CDD:206656	76/163 (47%)
RAB2A	NP_002856.1	PLN03108	1..188	CDD:178655	82/182 (45%)
		Required for interaction with PRKCI. /evidence=ECO:0000269|PubMed:14570876	2..19		5/10 (50%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P61106	37..42		3/4 (75%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P61106	63..72		6/8 (75%)