DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab18 and RAB18

DIOPT Version :9

Sequence 1:	NP_524744.2	Gene:	Rab18 / 44360	FlyBaseID:	FBgn0015794	Length:	197	Species:	Drosophila melanogaster
Sequence 2:	NP_001243339.1	Gene:	RAB18 / 22931	HGNCID:	14244	Length:	235	Species:	Homo sapiens

Alignment Length:	225	Identity:	102/225 - (45%)
Similarity:	134/225 - (59%)	Gaps:	34/225 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKLLVIGESGVGKSSLIRRFVENKFDQNHDVTIGMDFKSKVMQVDGIDYKVALW----------- 59
            :|:|:|||||||||||:.||.::.||.....|||:|||.|.:.|||...|:|:|
Human     9 LKILIIGESGVGKSSLLLRFTDDTFDPELAATIGVDFKVKTISVDGNKAKLAIWVTLHQQTANFF 73

  Fly    60 ------------------DTAGAERFRSLTPSFYRKALGAILVYDITSRDSLVKLETWLAELDSY 106
                              ||||.||||:||||:||.|.|.|||||:|.||:.|||:.||.||::|
Human    74 LKSQIGNSPILKWAMWQYDTAGQERFRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETY 138

  Fly   107 SDNPNIAIIVVGNKIDEE-RVVDREEGRKFARKHRALFIETSAKCDQFVSDVFKDVVEKIVSSE- 169
            ....:|..::||||||:| |.|||.||.||||||..||||.|||....|...|:::||||:.:.
Human   139 CTRNDIVNMLVGNKIDKENREVDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPG 203

  Fly   170 YFNNGNASAGLDIASDRDLEASASTC--YC 197
            .:.:.|.:.|:.: |.|:.......|  ||
Human   204 LWESENQNKGVKL-SHREEGQGGGACGGYC 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab18	NP_524744.2	RAB	6..166	CDD:197555	94/189 (50%)
Rab18	NP_524744.2	Rab18	6..165	CDD:206656	93/188 (49%)
RAB18	NP_001243339.1	Rab18	9..198	CDD:206656	93/188 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	184	1.000	Domainoid score	I3409
eggNOG	1	0.900	-	-		E1_KOG0080
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40765
Inparanoid	1	1.050	187	1.000	Inparanoid score	I3934
Isobase	1	0.950	-	0	Normalized mean entropy	S547
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247169at2759
OrthoFinder	1	1.000	-	-		FOG0004111
OrthoInspector	1	1.000	-	-		oto88833
orthoMCL	1	0.900	-	-		OOG6_101993
Panther	1	1.100	-	-	LDO	PTHR24073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2740
SonicParanoid	1	1.000	-	-		X2853
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.810