Protein Alignment Rab18 and RAB35

DIOPT Version :10

• Sequence 1: NP_524744.2
• Gene: Rab18 / 44360
• FlyBaseID: FBgn0015794
• Length: 197
• Species: Drosophila melanogaster
• Sequence 2: NP_006852.1
• Gene: RAB35 / 11021
• HGNCID: 9774
• Length: 201
• Species: Homo sapiens
• Alignment Length: 172
• Identity: 73/172 - (42%)
• Similarity: 113/172 - (65%)
• Gaps: 4/172 - (2%)

  Fly     3 DRAIKLLVIGESGVGKSSLIRRFVENKFDQNHDVTIGMDFKSKVMQVDGIDYKVALWDTAGAERF 67
            |...|||:||:||||||||:.||.:|.|..::..|||:|||.:.::::|...|:.:|||||.|||
Human     6 DHLFKLLIIGDSGVGKSSLLLRFADNTFSGSYITTIGVDFKIRTVEINGEKVKLQIWDTAGQERF 70

  Fly    68 RSLTPSFYRKALGAILVYDITSRDSLVKLETWLAELDSYSDNPNIAIIVVGNKID--EERVVDRE 130
            |::|.::||...|.|:|||:||.:|.|.::.||.|::...|  ::..|:||||.|  |.:||:.|
Human    71 RTITSTYYRGTHGVIVVYDVTSAESFVNVKRWLHEINQNCD--DVCRILVGNKNDDPERKVVETE 133

  Fly   131 EGRKFARKHRALFIETSAKCDQFVSDVFKDVVEKIVSSEYFN 172
            :..|||.:......|||||.:..|.::|..:.|.::.::..|
Human   134 DAYKFAGQMGIQLFETSAKENVNVEEMFNCITELVLRAKKDN 175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab18	NP_524744.2	Rab18	6..165	CDD:206656	71/160 (44%)
RAB35	NP_006852.1	Rab35	3..201	CDD:133310	73/172 (42%)
		Switch 1. /evidence=ECO:0000269|PubMed:30905672, ECO:0007744|PDB:6IF2, ECO:0007744|PDB:6IF3	30..42		3/11 (27%)
		Switch 2. /evidence=ECO:0000269|PubMed:30905672, ECO:0007744|PDB:6IF2, ECO:0007744|PDB:6IF3	64..80		9/15 (60%)