Protein Alignment CG46339 and AAP1

DIOPT Version :10

• Sequence 1: NP_001263001.1
• Gene: CG46339 / 44359
• FlyBaseID: FBgn0285963
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_011913.1
• Gene: AAP1 / 856443
• SGDID: S000001089
• Length: 856
• Species: Saccharomyces cerevisiae
• Alignment Length: 918
• Identity: 256/918 - (27%)
• Similarity: 407/918 - (44%)
• Gaps: 113/918 - (12%)

  Fly   296 PLHYSLLIEPSVATSISNGSLTIEIERDVSKVTSWE--PIVLDVHNVSISNVRVIRALADGASNA 358
            ||||.:.:||:.......|||.|:::.:...:.|.:  .:.:|.|:..|..|..|..      |.
Yeast    12 PLHYDITLEPNFRAFTFEGSLKIDLQINDHSINSVQINYLEIDFHSARIEGVNAIEV------NK 70

  Fly   359 SEEQD---LDFDSDYGEDNATFVINLSKTLAVETQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDT 420
            :|.|.   |.|      .|.||     :.|....:|.::    |...:.|.:.|.|:..||:..|
Yeast    71 NENQQKATLVF------PNGTF-----ENLGPSAKLEII----FSGILNDQMAGFYRAKYTDKVT 120

  Fly   421 KNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFRRGFIRDD 485
            ...::|.:||....||||||||||.|::||.|::::|.. .|...||||... :...:.|.....
Yeast   121 GETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSE-SFLTHLSNMDVR-NETIKEGKKYTT 183

  Fly   486 FETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFVGMTHYAYKMVRKFLPYYEDFF 550
            |.|||||.||||||||:   |.|....::...| |.:::.|.......:|..:..:.|.::||.|
Yeast   184 FNTTPKMSTYLVAFIVA---DLRYVESNNFRIP-VRVYSTPGDEKFGQFAANLAARTLRFFEDTF 244

  Fly   551 GIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAHQW 615
            .|:..|||:|:|:|.:|...|||||||:|:|...||:  |:: .||.:.:|.||.:|.|||||||
Yeast   245 NIEYPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLL--DIE-NSSLDRIQRVAEVIQHELAHQW 306

  Fly   616 FGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHDADNTSHAISFDV 680
            ||||||..||:.|||.||||.:||:.:.....||::..:.......:.::..|:..:||.|...|
Yeast   307 FGNLVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPV 371

  Fly   681 RSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLW-AMLTRHGH 744
            .:.:::.:|||.||||||:.||||::..:|:..|.......|.||.|||....||| |:....|
Yeast   372 NNADEINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASG- 435

  Fly   745 EQGTLPKDLSVKQIMDSWITQPGYPVVNVERRGADLVLRQERYLLPSKNTADQSTWFIPITFETD 809
                  ||  |..:|:.|..:.|:||::|:.....:.|.|.|||.......::.|...||.....
Yeast   436 ------KD--VCSVMNIWTKRVGFPVLSVKEHKNKITLTQHRYLSTGDVKEEEDTTIYPILLALK 492

  Fly   810 ELRKGDNIPTHWMRSEDEEELIVGNVFAHSSNSDNVIYLN-------LNRQGYYRVNYDMTS--- 864
            :                            |:..||.:.||       |..:.::::|.|.:.
Yeast   493 D----------------------------STGIDNTLVLNEKSATFELKNEEFFKINGDQSGIFI 529

  Fly   865 -------WLALKKNFSTLPRITRAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELLWIAAK 922
                   |..|.|..:.|....|..|:.||..||.:.| |.......|:..:...|..::|....
Yeast   530 TSYSDERWAKLSKQANLLSVEDRVGLVADAKALSASGY-TSTTNFLNLISNWKNEDSFVVWEQII 593

  Fly   923 PGLNYLIYNLKREPAYETFRAFMKF---IVRPAFDHYGLHEPDNESHLQLKHRALVAYFACKFNY 984
            ..|:.|......||. :...|..||   :|.......|.:..:::|....:.:..:...||....
Yeast   594 NSLSALKSTWVFEPE-DILNALDKFTLDLVLNKLSELGWNIGEDDSFAIQRLKVTLFSAACTSGN 657

  Fly   985 DRCTQKAQMKFREWMRDPKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILT 1049
            ::....|...|.|:....| ..|....|:|::.|....|....:...:..|:...|:.||...|.
Yeast   658 EKMQSIAVEMFEEYANGNK-QAIPALFKAVVFNTVARLGGENNYEKIFNIYQNPVSSEEKIIALR 721

  Fly  1050 SLGCTTKPWLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDG 1114
            :||......||.:.|:..::.|  :|.||..:..:.:..:..|.|..:.::|.:..||.:....|
Yeast   722 ALGRFEDKELLERTLSYLLDGT--VLNQDFYIPMQGIRVHKKGIERLWAWMQEHWDEIAKRLQPG 784

  Fly  1115 FSTLSEMIKSLTIYMNKDYHKHQLLDLAATCRKLGLHAVESAIELALEQVNNNIYW--------- 1170
            ...|..:   ||:.:........|..::|...:......:..:..||:.:.:...|
Yeast   785 SPVLGGV---LTLGLTNFTSFEALEKISAFYSRKVTKGFDQTLAQALDTIRSKAQWVSRDREIVA 846

  Fly  1171 ---RSHSY 1175
               |.|.|
Yeast   847 TYLREHEY 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	M1_APN-Q_like	297..764	CDD:341064	168/472 (36%)
		ERAP1_C	846..1126	CDD:463368	62/299 (21%)
AAP1	NP_011913.1	M1_APN-Q_like	13..447	CDD:341064	168/472 (36%)
		ERAP1_C	517..833	CDD:463368	65/323 (20%)