DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and AAP1

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_011913.1	Gene:	AAP1 / 856443	SGDID:	S000001089	Length:	856	Species:	Saccharomyces cerevisiae

Alignment Length:	918	Identity:	256/918 - (27%)
Similarity:	407/918 - (44%)	Gaps:	113/918 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 PLHYSLLIEPSVATSISNGSLTIEIERDVSKVTSWE--PIVLDVHNVSISNVRVIRALADGASNA 358
            ||||.:.:||:.......|||.|:::.:...:.|.:  .:.:|.|:..|..|..|..      |.
Yeast    12 PLHYDITLEPNFRAFTFEGSLKIDLQINDHSINSVQINYLEIDFHSARIEGVNAIEV------NK 70

  Fly   359 SEEQD---LDFDSDYGEDNATFVINLSKTLAVETQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDT 420
            :|.|.   |.|      .|.||     :.|....:|.::    |...:.|.:.|.|:..||:..|
Yeast    71 NENQQKATLVF------PNGTF-----ENLGPSAKLEII----FSGILNDQMAGFYRAKYTDKVT 120

  Fly   421 KNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFRRGFIRDD 485
            ...::|.:||....||||||||||.|::||.|::::|.. .|...||||... :...:.|.....
Yeast   121 GETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSE-SFLTHLSNMDVR-NETIKEGKKYTT 183

  Fly   486 FETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFVGMTHYAYKMVRKFLPYYEDFF 550
            |.|||||.||||||||:   |.|....::...| |.:::.|.......:|..:..:.|.::||.|
Yeast   184 FNTTPKMSTYLVAFIVA---DLRYVESNNFRIP-VRVYSTPGDEKFGQFAANLAARTLRFFEDTF 244

  Fly   551 GIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAHQW 615
            .|:..|||:|:|:|.:|...|||||||:|:|...||:  |:: .||.:.:|.||.:|.|||||||
Yeast   245 NIEYPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLL--DIE-NSSLDRIQRVAEVIQHELAHQW 306

  Fly   616 FGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHDADNTSHAISFDV 680
            ||||||..||:.|||.||||.:||:.:.....||::..:.......:.::..|:..:||.|...|
Yeast   307 FGNLVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPV 371

  Fly   681 RSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLW-AMLTRHGH 744
            .:.:::.:|||.||||||:.||||::..:|:..|.......|.||.|||....||| |:....|
Yeast   372 NNADEINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASG- 435

  Fly   745 EQGTLPKDLSVKQIMDSWITQPGYPVVNVERRGADLVLRQERYLLPSKNTADQSTWFIPITFETD 809
                  ||  |..:|:.|..:.|:||::|:.....:.|.|.|||.......::.|...||.....
Yeast   436 ------KD--VCSVMNIWTKRVGFPVLSVKEHKNKITLTQHRYLSTGDVKEEEDTTIYPILLALK 492

  Fly   810 ELRKGDNIPTHWMRSEDEEELIVGNVFAHSSNSDNVIYLN-------LNRQGYYRVNYDMTS--- 864
            :                            |:..||.:.||       |..:.::::|.|.:.
Yeast   493 D----------------------------STGIDNTLVLNEKSATFELKNEEFFKINGDQSGIFI 529

  Fly   865 -------WLALKKNFSTLPRITRAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELLWIAAK 922
                   |..|.|..:.|....|..|:.||..||.:.| |.......|:..:...|..::|....
Yeast   530 TSYSDERWAKLSKQANLLSVEDRVGLVADAKALSASGY-TSTTNFLNLISNWKNEDSFVVWEQII 593

  Fly   923 PGLNYLIYNLKREPAYETFRAFMKF---IVRPAFDHYGLHEPDNESHLQLKHRALVAYFACKFNY 984
            ..|:.|......||. :...|..||   :|.......|.:..:::|....:.:..:...||....
Yeast   594 NSLSALKSTWVFEPE-DILNALDKFTLDLVLNKLSELGWNIGEDDSFAIQRLKVTLFSAACTSGN 657

  Fly   985 DRCTQKAQMKFREWMRDPKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILT 1049
            ::....|...|.|:....| ..|....|:|::.|....|....:...:..|:...|:.||...|.
Yeast   658 EKMQSIAVEMFEEYANGNK-QAIPALFKAVVFNTVARLGGENNYEKIFNIYQNPVSSEEKIIALR 721

  Fly  1050 SLGCTTKPWLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDG 1114
            :||......||.:.|:..::.|  :|.||..:..:.:..:..|.|..:.::|.:..||.:....|
Yeast   722 ALGRFEDKELLERTLSYLLDGT--VLNQDFYIPMQGIRVHKKGIERLWAWMQEHWDEIAKRLQPG 784

  Fly  1115 FSTLSEMIKSLTIYMNKDYHKHQLLDLAATCRKLGLHAVESAIELALEQVNNNIYW--------- 1170
            ...|..:   ||:.:........|..::|...:......:..:..||:.:.:...|
Yeast   785 SPVLGGV---LTLGLTNFTSFEALEKISAFYSRKVTKGFDQTLAQALDTIRSKAQWVSRDREIVA 846

  Fly  1171 ---RSHSY 1175
               |.|.|
Yeast   847 TYLREHEY 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	145/406 (36%)
		M1_APN_2	297..769	CDD:189008	169/477 (35%)
		ERAP1_C	846..1138	CDD:288671	64/311 (21%)
AAP1	NP_011913.1	PepN	2..844	CDD:223385	253/906 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	4	4.010