DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG46339 and TMA108

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_012129.1	Gene:	TMA108 / 854669	SGDID:	S000001399	Length:	946	Species:	Saccharomyces cerevisiae

Alignment Length:	885	Identity:	205/885 - (23%)
Similarity:	348/885 - (39%)	Gaps:	169/885 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 PLHYSLLIE--PSVATSISNGSLTIEIERDVSKVT--------------SWEPIVLDVHNVSISN 344
            |.||.|.:|  |..::....||..|.::.:.:..|              |.:.|||..|
Yeast    14 PSHYELRLEIDPKQSSPNFKGSAIIHLKFNPNSTTLASIEDSFTQFKLHSKDLIVLSAH------ 72

  Fly   345 VRVIRALADGASNASEEQDLDFDSDYGEDNATFVINLSKTLAVETQLRVLLSLDFVSQVTDTLQ- 408
                      |:..|.:.||....|.|:..:.|  |....:.:.....::||:.:|.::.|...
Yeast    73 ----------ATIGSTKFDLKISQDTGKHLSIF--NSESPIQLSNDCPLILSVQYVGKIRDIKTH 125

  Fly   409 -----GIYKTSYTNPDTKN-EEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALS 467
                 ||:||::.:..|.. ...:::|...|..|...|||.|.|..|:.|.::|....|:| |:|
Yeast   126 HDKTFGIFKTNFMDRKTGTANNHVVATHCQPFSASNIFPCIDEPSNKSTFQLNIATDAQYK-AVS 189

  Fly   468 NMP-------KSGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNM--VDSRLASQDSGLTPRVEIW 523
            |.|       .|..:...:      |..||.|.|.:..|.:.::  :.:.:..:.....| |.|:
Yeast   190 NTPVEMVEALDSSQKHLVK------FAKTPLMTTSVFGFSIGDLEFLKTEIKLEGDRTIP-VSIY 247

  Fly   524 TRPQFVGMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVP 588
            . |..:....:....|:|:||..|.:|.....|||:|.|.:|.....||||:|:||.:.:.||:|
Yeast   248 A-PWDIANAAFTLDTVQKYLPLLESYFKCPYPLPKLDFVLLPYLSDMAMENFGMITIQLNHLLIP 311

  Fly   589 EDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEH----AHPE 649
            .: .||:.:...| ...:|.|||.|||.||.::...|:.||..|.||.:::...||.    :|
Yeast   312 PN-ALANETVREQ-AQQLIVHELVHQWMGNYISFDSWESLWFNESFATWLACHILEQNGDLSH-- 372

  Fly   650 FQSMDTLTMLEFKESMEHDADNTSHAISFDVRSTN-----DVRRIFDPISYSKGTILLRMLNSIV 709
            :.:.:...:.:.:.:|..||.:.:....|.:...|     ....||||.:|:||.|:||.|....
Yeast   373 YWTSEPYLLQQVEPTMCRDAADVNGRSIFQIAQRNTGIDSQTSDIFDPEAYTKGIIMLRSLQLAT 437

  Fly   710 GDVAFRSATRDLL---KKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVV 771
            |:...:.....:.   |.|...::...|:|       :..|...|..::...:.||...||.|||
Yeast   438 GESHLQKGLESVFEDTKTFHARSVKPMDIW-------NHIGKFLKSQNITNFVSSWTRTPGLPVV 495

  Fly   772 NVERRGAD----LVLRQERYL----LPSKNTADQSTWFIPI-------------TFETDELRKGD 815
            .||....|    ..|.|.|::    ...|:..:...:.:|:             ...||...|.|
Yeast   496 KVEVEEKDGKTQTKLTQHRFINQLSTEEKDQLEDVPYQVPLFGVLPDGKMDTKNVLLTDRTLKFD 560

  Fly   816 NIPTHWMRSEDEEELIVGNVFAHSSNSDNVIYLNLNRQGYYRVNYDMTSWLALKKNFSTLPRITR 880
             .|                          ::.:|...||||||:|:.....||..:..|...::.
Yeast   561 -YP--------------------------ILVINHLAQGYYRVSYESEECYALINDKITEETLSE 598

  Fly   881 AQLLDDALHLSQ---AEYLTYDIPLTFLMELFDAVDDELLWIAAK------PGLNYLIYNLKREP 936
            ..|....|.|||   .|.....|.|..|.::.:.:......||:|      .||..|....:...
Yeast   599 IDLRKIFLDLSQFIGDEGFQNSIHLHGLFKILNHIASPSTKIASKYWDPLSKGLEVLQTIDRASL 663

  Fly   937 AYETFRAFM-KFIVRPAFDH----YGLHEPDNESHLQLKHRALVAYFACKFNYDRCTQKAQMKFR 996
            .....::|: |.||.|.|:.    :|..:.....| :||..:.|.:.  ..|..:|.:..|:.|:
Yeast   664 TSSKLQSFLKKKIVIPLFNKIDWPHGEFDKSTNPH-ELKVMSQVLFL--NKNSAKCAELCQIYFK 725

  Fly   997 EWMRDPKNNPIKPNLKSVI-----YCTSLAE--------------GSSPEWYFAYKQYKTTTSAS 1042
            ..::.|:::.....:.|::     :|.::.:              |.:......|.|..:.|:..
Yeast   726 HLLQGPRSSVPLELVNSILVVVSQHCANIKQWKKIFDLVKRSSCTGITNHVINMYDQNSSETAML 790

  Fly  1043 EKEEILTSLGCTTKPWLLSKYLNMTINPTSGILKQDGALA 1082
            .:...:.|||......::.|.||..   ||.|..:...||
Yeast   791 IQNGAIESLGFCLDSDIVKKTLNFI---TSNIESEGMELA 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	113/442 (26%)
		M1_APN_2	297..769	CDD:189008	129/515 (25%)
		ERAP1_C	846..1138	CDD:288671	59/270 (22%)
TMA108	NP_012129.1	PepN	7..941	CDD:223385	205/885 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010