DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and AOPEP

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001372995.1	Gene:	AOPEP / 84909	HGNCID:	1361	Length:	859	Species:	Homo sapiens

Alignment Length:	655	Identity:	144/655 - (21%)
Similarity:	231/655 - (35%)	Gaps:	172/655 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 LTIEIERDVSKVTSWEPIV----LDVHNVSISNVRVIRALADGASNASEEQ-------------- 362
            |.:| |.||:.|...|...    |.|.:....| :::|.|....:|...||
Human   154 LKVE-EVDVAAVPGLEKFTRSPELTVVSEEFRN-QIVRELVTLPANRWREQLDYYARCSQAPGCG 216

  Fly   363 DLDFDSDYGEDNATFVINLSKTLAVETQLRVLLSLDFVSQVTDTLQGI---YKTSYTNPDTKNEE 424
            :|.||:|      |:.:.:.||.|              ...||....|   ||   |.|:.::..
Human   217 ELLFDTD------TWSLQIRKTGA--------------QTATDFPHAIRIWYK---TKPEGRSVT 258

  Fly   425 W--------MISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFRRGF 481
            |        .:.|..||::.|..|||.:.|...:.:..::.....|.:.:|....:...:.....
Human   259 WTSDQSGRPCVYTVGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGENSAKPTQLWEEC 323

  Fly   482 IRDDFETTPKMPTYLVAFIVSNMVDSRLASQDS-------------------GLTPRVEIWTRPQ 527
            ....:..|..||.......|....:.::.:..|                   |:...:|...|.|
Human   324 SSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLATERPFSPSEANFRHVGVCSHMEYPCRFQ 388

  Fly   528 FVGMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITF-RDSALLVPEDL 591
            ....|.......|.|.|..     :.....:..|..:|....||....|...| |...|:||.:.
Human   389 NASATTQEIIPHRVFAPVC-----LTGACQETLLRLIPPCLSAAHSVLGAHPFSRLDVLIVPANF 448

  Fly   592 -QLASSSEHMQVVAGII------------AHELAHQWFGNLVTPKWWDDLWLKEGFACYMS---- 639
             .|..:|.|:..::..|            .||:||.|||..:..:.|.:.||.||||.::.
Human   449 PSLGMASPHIMFLSQSILTGGNHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDVFW 513

  Fly   640 --------YKALE-----------HAHPEFQ-SMDTLTMLE-FKESMEHDADNTSHAISFDVRST 683
                    |:|.|           ....|.| |.:.:.:|. .|:...|.:|:.:..|...:
Human   514 ATAQQLAPYEAREQQELRACLRWRRLQDEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGL--- 575

  Fly   684 NDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGT 748
             :..:||..:.|.||..|||.|...:||..:.|..|..:..|....:...|...||..:..|:..
Human   576 -NPEKIFMQVHYLKGYFLLRFLAKRLGDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKR 639

  Fly   749 LPKDLSVKQIMDSWITQPGYP-VVNVERR-GADLVL----------------------RQER--- 786
            |  :|||:.|...|:...|.| .:..||| ||:..|                      |:|:
Human   640 L--ELSVENIYQDWLESSGIPKPLQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEV 702

  Fly   787 --YLLPS------KNTADQSTWFIPITFETDELRKGDNIPTHWMRSEDEE------ELIVGNVFA 837
              .|||.      ::..:|.| ..|.|.::  |::     |:.::.:|.|      ||||.:.|.
Human   703 FEKLLPDQLVLLLEHLLEQKT-LSPRTLQS--LQR-----TYHLQDQDAEVRHRWCELIVKHKFT 759

  Fly   838 HSSNS 842
            .:..|
Human   760 KAYKS 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	96/468 (21%)
		M1_APN_2	297..769	CDD:189008	118/539 (22%)
		ERAP1_C	846..1138	CDD:288671
AOPEP	NP_001372995.1	GluZincin	<244..652	CDD:417498	91/421 (22%)
		Nucleolar localization signal. /evidence=ECO:0000250\|UniProtKB:Q8BXQ6	689..699		1/9 (11%)
		Leuk-A4-hydro_C	721..>771	CDD:401171	14/52 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155428
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840