DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and APM1

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_195035.2	Gene:	APM1 / 829446	AraportID:	AT4G33090	Length:	879	Species:	Arabidopsis thaliana

Alignment Length:	913	Identity:	263/913 - (28%)
Similarity:	425/913 - (46%)	Gaps:	107/913 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 PLHYSLLIEPSVATSISNGSLTIEIERDVSKVTSWEPIVLDVHNVSISNVRV-------IRALAD 353
            |..|.|.:.|.:......|  |:.|:.|:...|.:  |||:..::|:::..|       .:|||.
plant    16 PKRYDLRLNPDLIACTFTG--TVAIDLDIVADTRF--IVLNAADLSVNDASVSFTPPSSSKALAA 76

  Fly   354 GASNASEEQDLDFDSDYGEDNATFVINLSKTLAVETQLRVLLSLDFVSQVTDTLQGIYKTSYT-N 417
            ......||.:: ...::||       .|...:.|       |.|.|...:.|.::|.|:::|. |
plant    77 PKVVLFEEDEI-LVLEFGE-------ILPHGVGV-------LKLGFNGVLNDKMKGFYRSTYEHN 126

  Fly   418 PDTKNEEWMISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMP-----KSGSRRF 477
            .:.||   |..|||.|.||||.|||:|.|..||.|.|::..|... :||||||     .:|:.:.
plant   127 GEKKN---MAVTQFEPADARRCFPCWDEPACKATFKITLEVPTDL-VALSNMPIMEEKVNGNLKI 187

  Fly   478 RRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFVGMTHYAYKMVRKF 542
                  ..::.:|.|.|||||.:| .:.|........|:  :|.::.:........:|..:..|.
plant   188 ------VSYQESPIMSTYLVAIVV-GLFDYVEDHTSDGI--KVRVYCQVGKADQGKFALHVGAKT 243

  Fly   543 LPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAGII 607
            |..::::|.:...|||:|::::|||...||||:||:|:|::|||..|....||:.   |.||.::
plant   244 LDLFKEYFAVPYPLPKMDMIAIPDFAAGAMENYGLVTYRETALLYDEQHSAASNK---QRVATVV 305

  Fly   608 AHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHPEF----QSMDTLTMLEFKESMEHD 668
            ||||||||||||||.:||..|||.||||.::||.|.:...||:    |.:|     |..|.:..|
plant   306 AHELAHQWFGNLVTMEWWTHLWLNEGFATWVSYLATDSLFPEWKIWTQFLD-----ESTEGLRLD 365

  Fly   669 ADNTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRD 733
            ....||.|..:|....::..|||.|||.||..::|||.|.:|...|:.:....:|..||.|...:
plant   366 GLEESHPIEVEVNHAAEIDEIFDAISYRKGASVIRMLQSYLGAEVFQKSLAAYIKNHAYSNAKTE 430

  Fly   734 DLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNVERRGADLVLRQERYLLPSKNTADQS 798
            ||||.|.....|        .|.::|.||..|.|||||:.:.:...|.|.|.|:|  |..:..:.
plant   431 DLWAALEAGSGE--------PVNKLMSSWTKQKGYPVVSAKIKDGKLELEQSRFL--SSGSPGEG 485

  Fly   799 TWFIPITFETDELRKGDNIPTHWMRSE----DEEELIVGNVFAHSSNSDNV------IYLNLNRQ 853
            .|.:|:|.......|..|.   .:.|:    |.:||:..::   :..||.:      |.:|:::.
plant   486 QWIVPVTLCCGSYEKRKNF---LLESKSGAYDLKELLGCSI---ADGSDKINGTCSWIKINVDQA 544

  Fly   854 GYYRVNYD--MTSWLALKKNFSTLPRITRAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDEL 916
            |:|||.||  :.:.|.......:|..|.|..:|||:..|:.|...:    |..|:.|..|...||
plant   545 GFYRVKYDDSLAAGLRNATESQSLTSIDRYGILDDSFALTMARQQS----LASLLTLCSAYKKEL 605

  Fly   917 LW--IAAKPGLNYLIYNLKREPAYETFRAFMKFIV---RPAFDHYGLHEPDNESHLQLKHRALVA 976
            .:  ::....::|.:..:..:...|.......|.:   :.|....|......||||....|..|.
plant   606 DYTVLSNLIAISYKVVKIGADANQELMSGIKHFFIGVFQFAAGKLGWDPKQGESHLDAMLRGEVL 670

  Fly   977 YFACKFNYDRCTQKAQMKFREWMRDPKNNP-IKPNLKSVIYCTSL--AEGSSPEWYFA-YKQYKT 1037
            .....|.:|...::|..:|..::.| :|.| :.|:::...|...:  |..|....|.: .:.|:.
plant   671 TALAVFGHDETLKEAVRRFDAFLAD-RNTPLLPPDIRRAAYVAVMQRANKSDKSGYESLLRVYRE 734

  Fly  1038 TTSASEKEEILTSLGCTTKPWLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQG 1102
            |..:.||..||.||.....|.::...||..:  :..:..||.......|:..  |.|:|:.:||.
plant   735 TDLSQEKTRILGSLASCPDPTIVQDVLNFVL--SDEVRNQDALYGLSGVSWE--GREVAWKWLQE 795

  Fly  1103 NIKEIVEYYGDGFSTLSEMIKSLTIYMNKDYHKHQLLDLAATCRKLGLHAVESAIELALEQVNNN 1167
            ..:.|...:|.|| .::..|.::...........::.:..||..|   .::...::.::|:|:.|
plant   796 KWEYIGNTWGSGF-LITRFISAVVSPFASFEKAKEVEEFFATRSK---PSMARTLKQSIERVHIN 856

  Fly  1168 IYW 1170
            ..|
plant   857 ANW 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	141/418 (34%)
		M1_APN_2	297..769	CDD:189008	164/488 (34%)
		ERAP1_C	846..1138	CDD:288671	70/302 (23%)
APM1	NP_195035.2	M1_APN-Q_like	18..453	CDD:341064	162/482 (34%)
APM1	NP_195035.2	ERAP1_C	536..855	CDD:403137	75/331 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020