Protein Alignment CG46339 and Lvrn

DIOPT Version :10

• Sequence 1: NP_001263001.1
• Gene: CG46339 / 44359
• FlyBaseID: FBgn0285963
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_083284.1
• Gene: Lvrn / 74574
• MGIID: 1921824
• Length: 991
• Species: Mus musculus
• Alignment Length: 1102
• Identity: 298/1102 - (27%)
• Similarity: 485/1102 - (44%)
• Gaps: 202/1102 - (18%)

  Fly   150 SGVYVSKACLIIAAFITVLALLFTIAI-TYFVTRQGLNPKEVTPPSCITADHPDVNATPIQTAGW 213
            ||||||:...::.|.:|.:.||..:|: :.:.:...:.|.|            ..|:....|:.|
Mouse     7 SGVYVSRGVALLLAALTAVLLLVLVALASLYGSCAHVQPSE------------QGNSRVKNTSLW 59

  Fly   214 VSMNSPPPLQAATPTPMASPTPTNTPTVTTTLAM-PASSEKPEIRMVDPKVGDIPVVEPAAGEVE 277
                 ||..|     ..|.|||...|||.|:..: |.|.....:|:
Mouse    60 -----PPGGQ-----EWALPTPAQEPTVGTSQDLGPPSGPWDHLRL------------------- 95

  Fly   278 DNTTKPINRPLKLYEGWR-PLHYSLLIEP-------SVATSISNGSLTIEIERDVS--------- 325
                          ..|. ||||.|.:.|       |.......|.:.|.:...|:
Mouse    96 --------------PPWLVPLHYDLELWPWLQPDKLSPPNLTFTGRVNITVRCTVASSRLLLHSF 146

  Fly   326 -----KVTSWEPIVLDVHNVSISNVRVIRALADGASNASEEQDLDFDSDYGEDNATFVINLSKTL 385
                 :|..|.|:..|..|.::..|:|.:..                  :..|....|::|.::|
Mouse   147 LLNYKQVEVWGPLAQDTRNATVGRVQVEKVW------------------FAPDMQFVVLDLGQSL 193

  Fly   386 AVETQLRVLLSLDFVSQVTDT-LQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMK 449
              |...|..||..|..||... |:|::...|.:.|....  :::||..|..||..|||||.|.:|
Mouse   194 --EPGSRYELSFHFSGQVLQVGLEGLFLNLYHDEDELRA--LVATQMEPTFARHVFPCFDEPALK 254

  Fly   450 ANFSISIVRPMQFKMALSNMPK---------SGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMV 505
            |.|:|:::....: .||||||:         :|||     :....|.|||:|||||||.:|.::
Mouse   255 ATFNITVIHHPGY-AALSNMPQLGQSERIDVNGSR-----WTVTTFHTTPRMPTYLVALVVCDL- 312

  Fly   506 DSRLASQDSGLTPRVEIWTRPQFV--GMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFG 568
             ..::..:.|  ..:.:|.|...:  |...:|..:......:.||.|.|..:|||.|:|::|.|.
Mouse   313 -DHISRTERG--KEIRVWARKDDIASGYLDFAANITGPIFSFLEDLFNISYRLPKTDIVALPIFA 374

  Fly   569 FAAMENWGLITFRDSALLV-PEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKE 632
            ..|||||||:.|.:|:||: |||    ..:|...::..|||||:.|||||||||..||:::||.|
Mouse   375 SGAMENWGLLIFDESSLLLEPED----ELTEKRAMILSIIAHEVGHQWFGNLVTMSWWNNIWLNE 435

  Fly   633 GFACYMSYKALEHAHPE--FQSMDTLTMLEFKESMEHDADNTSHAISFDVRS---TNDVRRIFDP 692
            |||.|...:...:.:|:  ...:...|:|......:|..:  |.|:|..|.:   |:::.|:||.
Mouse   436 GFASYFELELTNYFYPKVPMNMIFFFTVLHGILGEDHALE--SRAVSTAVENFTETSEINRLFDL 498

  Fly   693 ISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQ 757
            .:|.||..:..||.|.:....|.:|.:..|:.|:|.|.::||||..:.....||.......:||.
Mouse   499 YTYKKGACMAWMLASFLSPHLFINALKSYLETFSYSNAEQDDLWRHIQMAIGEQNVTHLPATVKG 563

  Fly   758 IMDSWITQPGYPVVNVERRGADLVLRQERYLLPSKNT----ADQSTWFIPITFETDELRKGDNIP 818
            |||||..:.|:|::.|.....  |::||.:.|.....    :..|||.:||.:    ::.|...|
Mouse   564 IMDSWTHRGGFPIITVNVSTG--VVKQEPFYLDKVENQTLLSHNSTWIVPIFW----MKNGIPQP 622

  Fly   819 THWMRSEDEEELIVGNVFAHSSNSDNVIYLNLNRQGYYRVNYDMTSWL----ALKKNFSTLPRIT 879
            ..|:   |:..::...:....|:||.|| ||.|..||||||||...|.    .|:|:...:|.|.
Mouse   623 LVWL---DKSNMMFPGMKLSDSDSDWVI-LNFNVTGYYRVNYDELGWKKLSEQLEKDPKAIPVIN 683

  Fly   880 RAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELL-WIAAKPGL----------NYLIYNLK 933
            |.||:.||..|::..|:..:..|.  :..:.|.:||:| |......|          ||.:|.|.
Mouse   684 RLQLVSDAFALTKNNYIEIETALD--LTKYIAEEDEILVWFEVLLNLINREVIYDVNNYALYPLL 746

  Fly   934 RE-------PAYETFRAFMKFIVRPAFDHYGLHEPDNESHLQLKHRALVAYFACKFNYDRCTQKA 991
            ::       ..:.|:.|.::..|....|:|          |.|.....:...||....:.|.|.:
Mouse   747 KKYLLKRFNSIWNTYSAIIRENVASLQDNY----------LSLFSLERIFETACWLGLEDCLQLS 801

  Fly   992 QMKFREWMRDPKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTT---SASEKEEILTSLGC 1053
            :..|::|...|: ..|.|.:::.:.|:::|.||..:|.|.:..|..||   ..|.:..::.::.|
Mouse   802 RELFKKWTAHPE-TAIPPQIENAVLCSAVALGSDKDWDFLFNLYINTTEEEDESRRRRLVHAMSC 865

  Fly  1054 TTKPWLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYG-DGFST 1117
            :..||:|::::...|...|....:...:.  .||::.:|..||.|||..|...:.|.|| |....
Mouse   866 SKDPWILNRFMEYAITAVSSNFSETNIIV--VVATSEVGRYIAKDFLMDNWVAVTERYGMDWLDA 928

  Fly  1118 L----------SEMIKSLTIYMNKDYHKHQLLDLAATCRKLGLHAVESAIELA--LEQVNNN 1167
            |          .:.:..|..:.:....:||.:.:.|..:.:....:::...:|  :|.:..|
Mouse   929 LVPVLGRTVSTDQQVTELQHFFSTVLEEHQRVVVQAKLQAMKTKNLQNKKRIARVVEWLRKN 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	M1_APN-Q_like	297..764	CDD:341064	158/505 (31%)
		ERAP1_C	846..1126	CDD:463368	81/315 (26%)
Lvrn	NP_083284.1	M1_APN-Q_like	102..570	CDD:341064	158/505 (31%)
		ERAP1_C	645..964	CDD:463368	85/334 (25%)