DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and Lvrn

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_083284.1	Gene:	Lvrn / 74574	MGIID:	1921824	Length:	991	Species:	Mus musculus

Alignment Length:	1102	Identity:	298/1102 - (27%)
Similarity:	485/1102 - (44%)	Gaps:	202/1102 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 SGVYVSKACLIIAAFITVLALLFTIAI-TYFVTRQGLNPKEVTPPSCITADHPDVNATPIQTAGW 213
            ||||||:...::.|.:|.:.||..:|: :.:.:...:.|.|            ..|:....|:.|
Mouse     7 SGVYVSRGVALLLAALTAVLLLVLVALASLYGSCAHVQPSE------------QGNSRVKNTSLW 59

  Fly   214 VSMNSPPPLQAATPTPMASPTPTNTPTVTTTLAM-PASSEKPEIRMVDPKVGDIPVVEPAAGEVE 277
                 ||..|     ..|.|||...|||.|:..: |.|.....:|:
Mouse    60 -----PPGGQ-----EWALPTPAQEPTVGTSQDLGPPSGPWDHLRL------------------- 95

  Fly   278 DNTTKPINRPLKLYEGWR-PLHYSLLIEP-------SVATSISNGSLTIEIERDVS--------- 325
                          ..|. ||||.|.:.|       |.......|.:.|.:...|:
Mouse    96 --------------PPWLVPLHYDLELWPWLQPDKLSPPNLTFTGRVNITVRCTVASSRLLLHSF 146

  Fly   326 -----KVTSWEPIVLDVHNVSISNVRVIRALADGASNASEEQDLDFDSDYGEDNATFVINLSKTL 385
                 :|..|.|:..|..|.::..|:|.:..                  :..|....|::|.::|
Mouse   147 LLNYKQVEVWGPLAQDTRNATVGRVQVEKVW------------------FAPDMQFVVLDLGQSL 193

  Fly   386 AVETQLRVLLSLDFVSQVTDT-LQGIYKTSYTNPDTKNEEWMISTQFSPVDARRAFPCFDRPDMK 449
              |...|..||..|..||... |:|::...|.:.|....  :::||..|..||..|||||.|.:|
Mouse   194 --EPGSRYELSFHFSGQVLQVGLEGLFLNLYHDEDELRA--LVATQMEPTFARHVFPCFDEPALK 254

  Fly   450 ANFSISIVRPMQFKMALSNMPK---------SGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMV 505
            |.|:|:::....: .||||||:         :|||     :....|.|||:|||||||.:|.::
Mouse   255 ATFNITVIHHPGY-AALSNMPQLGQSERIDVNGSR-----WTVTTFHTTPRMPTYLVALVVCDL- 312

  Fly   506 DSRLASQDSGLTPRVEIWTRPQFV--GMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFG 568
             ..::..:.|  ..:.:|.|...:  |...:|..:......:.||.|.|..:|||.|:|::|.|.
Mouse   313 -DHISRTERG--KEIRVWARKDDIASGYLDFAANITGPIFSFLEDLFNISYRLPKTDIVALPIFA 374

  Fly   569 FAAMENWGLITFRDSALLV-PEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKE 632
            ..|||||||:.|.:|:||: |||    ..:|...::..|||||:.|||||||||..||:::||.|
Mouse   375 SGAMENWGLLIFDESSLLLEPED----ELTEKRAMILSIIAHEVGHQWFGNLVTMSWWNNIWLNE 435

  Fly   633 GFACYMSYKALEHAHPE--FQSMDTLTMLEFKESMEHDADNTSHAISFDVRS---TNDVRRIFDP 692
            |||.|...:...:.:|:  ...:...|:|......:|..:  |.|:|..|.:   |:::.|:||.
Mouse   436 GFASYFELELTNYFYPKVPMNMIFFFTVLHGILGEDHALE--SRAVSTAVENFTETSEINRLFDL 498

  Fly   693 ISYSKGTILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQ 757
            .:|.||..:..||.|.:....|.:|.:..|:.|:|.|.::||||..:.....||.......:||.
Mouse   499 YTYKKGACMAWMLASFLSPHLFINALKSYLETFSYSNAEQDDLWRHIQMAIGEQNVTHLPATVKG 563

  Fly   758 IMDSWITQPGYPVVNVERRGADLVLRQERYLLPSKNT----ADQSTWFIPITFETDELRKGDNIP 818
            |||||..:.|:|::.|.....  |::||.:.|.....    :..|||.:||.:    ::.|...|
Mouse   564 IMDSWTHRGGFPIITVNVSTG--VVKQEPFYLDKVENQTLLSHNSTWIVPIFW----MKNGIPQP 622

  Fly   819 THWMRSEDEEELIVGNVFAHSSNSDNVIYLNLNRQGYYRVNYDMTSWL----ALKKNFSTLPRIT 879
            ..|:   |:..::...:....|:||.|| ||.|..||||||||...|.    .|:|:...:|.|.
Mouse   623 LVWL---DKSNMMFPGMKLSDSDSDWVI-LNFNVTGYYRVNYDELGWKKLSEQLEKDPKAIPVIN 683

  Fly   880 RAQLLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELL-WIAAKPGL----------NYLIYNLK 933
            |.||:.||..|::..|:..:..|.  :..:.|.:||:| |......|          ||.:|.|.
Mouse   684 RLQLVSDAFALTKNNYIEIETALD--LTKYIAEEDEILVWFEVLLNLINREVIYDVNNYALYPLL 746

  Fly   934 RE-------PAYETFRAFMKFIVRPAFDHYGLHEPDNESHLQLKHRALVAYFACKFNYDRCTQKA 991
            ::       ..:.|:.|.::..|....|:|          |.|.....:...||....:.|.|.:
Mouse   747 KKYLLKRFNSIWNTYSAIIRENVASLQDNY----------LSLFSLERIFETACWLGLEDCLQLS 801

  Fly   992 QMKFREWMRDPKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTT---SASEKEEILTSLGC 1053
            :..|::|...|: ..|.|.:::.:.|:::|.||..:|.|.:..|..||   ..|.:..::.::.|
Mouse   802 RELFKKWTAHPE-TAIPPQIENAVLCSAVALGSDKDWDFLFNLYINTTEEEDESRRRRLVHAMSC 865

  Fly  1054 TTKPWLLSKYLNMTINPTSGILKQDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYG-DGFST 1117
            :..||:|::::...|...|....:...:.  .||::.:|..||.|||..|...:.|.|| |....
Mouse   866 SKDPWILNRFMEYAITAVSSNFSETNIIV--VVATSEVGRYIAKDFLMDNWVAVTERYGMDWLDA 928

  Fly  1118 L----------SEMIKSLTIYMNKDYHKHQLLDLAATCRKLGLHAVESAIELA--LEQVNNN 1167
            |          .:.:..|..:.:....:||.:.:.|..:.:....:::...:|  :|.:..|
Mouse   929 LVPVLGRTVSTDQQVTELQHFFSTVLEEHQRVVVQAKLQAMKTKNLQNKKRIARVVEWLRKN 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	135/440 (31%)
		M1_APN_2	297..769	CDD:189008	159/510 (31%)
		ERAP1_C	846..1138	CDD:288671	83/327 (25%)
Lvrn	NP_083284.1	Peptidase_M1	94..504	CDD:279741	137/480 (29%)
		M1_APN_2	102..575	CDD:189008	159/510 (31%)
		Substrate binding. /evidence=ECO:0000250	376..380		2/3 (67%)
		ERAP1_C	646..964	CDD:288671	85/333 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845870
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750