DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG46339 and ERAP2

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001123612.1	Gene:	ERAP2 / 64167	HGNCID:	29499	Length:	960	Species:	Homo sapiens

Alignment Length:	970	Identity:	294/970 - (30%)
Similarity:	469/970 - (48%)	Gaps:	119/970 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 EPAAGEVEDNTTKPINRPLKLYEGWRPLHYSLLIEPSVATSISNGSLTIEIERDVSKVTSWEPIV 334
            :|.|..|..|..:...:.|:|.....||||.|.:.|::.:.....|..||:.  ||..|.:  |:
Human    49 DPGAFPVATNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVL--VSNATQF--II 109

  Fly   335 LDVHNVSISNVRVIRALADGASNASEEQDLDFDSDY---GEDNATFVINLSKTLA------VETQ 390
            |...::.|:|          |:..|||     ||.|   |::.........:.:|      :...
Human   110 LHSKDLEITN----------ATLQSEE-----DSRYMKPGKELKVLSYPAHEQIALLVPEKLTPH 159

  Fly   391 LRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKNEEWMI--STQFSPVDARRAFPCFDRPDMKANFS 453
            |:..:::||.:::.|..:|.||::|.   |...|..|  .|.|.|..||.||||||.|..|||||
Human   160 LKYYVAMDFQAKLGDGFEGFYKSTYR---TLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFS 221

  Fly   454 ISIVRPMQFKMALSNMPKSGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVDSRLASQDSGLTP 518
            |.|.|..: .:|||||||..:.....|.:.|.||||.||.|||||:||.:. .|......||:
Human   222 IKIRRESR-HIALSNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDF-HSLSGFTSSGV-- 282

  Fly   519 RVEIWTRPQFVGMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGFAAMENWGLITFRDS 583
            :|.|:..|.....||||.:...|.|.:||.:|.|...|.|:||:::|||...|||||||||:|::
Human   283 KVSIYASPDKRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRET 347

  Fly   584 ALLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAHP 648
            :||.  |.:.:|:|:.:.|.. :|||||||||||||||.:||:|:|||||||.||...|:...:|
Human   348 SLLF--DPKTSSASDKLWVTR-VIAHELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYP 409

  Fly   649 EFQSMDTLTMLEFKESMEHDADNTSHAISFDVRSTNDVRRIFDPISYSKGTILLRMLNSIVGDVA 713
            |.|..|....:.| |.:..|:.|:|..||....:...::.:||.:||:||..:|.||...:|:..
Human   410 ELQFDDYFLNVCF-EVITKDSLNSSRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEK 473

  Fly   714 FRSATRDLLKKFAYGNMDRDDLWAMLTR-------------HGHEQGT------LPKDLSVKQIM 759
            |:......||||:|.|...||||:.|:.             |...:.|      |.::..||::|
Human   474 FQKGIIQYLKKFSYRNAKNDDLWSSLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMM 538

  Fly   760 DSWITQPGYPVVNVERRGADLVLRQERYLL------PS-KNTADQSTWFIPITFETDELRKGDNI 817
            .:|..|.|.|::.|::.|..|.|:|||:|.      |. :...::..|.||:|:.|.   ..:.|
Human   539 TTWTLQKGIPLLVVKQDGCSLRLQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTS---SSNVI 600

  Fly   818 PTHWMRSE-DEEELIVGNVFAHSSNSDNVIYLNLNRQGYYRVNYDMTSW----LALKKNFSTLPR 877
            ..|.::|: |..:|         ....:.:..|::..|||.|:|:...|    ..|.:|.:.|..
Human   601 HRHILKSKTDTLDL---------PEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLNQNHTLLRP 656

  Fly   878 ITRAQLLDDALHLSQAEYLTYD--IPLTFLMELFDAVDDELLWIAAKPGLNYL--IYNL--KR-- 934
            ..|..|:.|...|..|..||.|  :.:|:.::      .|....|...||:||  .|::  :|
Human   657 KDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQ------HETSSPALLEGLSYLESFYHMMDRRNI 715

  Fly   935 EPAYETFRAFMKFIVRPAFDHYGLHEPDNESHLQLKHRALVAYFACKFNYDRCTQKAQMKFREWM 999
            ....|..:.::....:|..|....  .|..|......|:.:...||..|:..|.|||...|.:||
Human   716 SDISENLKRYLLQYFKPVIDRQSW--SDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWM 778

  Fly  1000 RDPKNNPIKPNLKSVIYCTSLAEGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTKPWLLSKYL 1064
            .......|..::..::|  |:...::..|.:..:||:.:.|::|:.:||.:|..:.....|.|.:
Human   779 ESSGKLNIPTDVLKIVY--SVGAQTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLI 841

  Fly  1065 NMTINPTSGILK-QDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSEMIKSLTIY 1128
            .:.:.  ..::| |:.|....|:|....|.::|:||::.|...:::.:..|...:..:|...|.:
Human   842 ELGME--GKVIKTQNLAALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAH 904

  Fly  1129 MNKDYHKHQLLDLAATCRKLGLHAVES------AIELALEQVNNNIYWRSHSYHSLKNFL 1182
            .:.   |.:|.::     ||...::|:      ..:..||.:..||.|...:..:|:.:|
Human   905 FSS---KDKLQEV-----KLFFESLEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWL 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	160/412 (39%)
		M1_APN_2	297..769	CDD:189008	186/501 (37%)
		ERAP1_C	846..1138	CDD:288671	70/304 (23%)
ERAP2	NP_001123612.1	Peptidase_M1	68..458	CDD:279741	161/419 (38%)
		M1_APN_2	76..548	CDD:189008	186/501 (37%)
		Substrate binding	334..338		2/3 (67%)
		ERAP1_C	621..938	CDD:288671	76/336 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155372
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850