DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG46339 and Enpep

DIOPT Version :9

Sequence 1:	NP_001263001.1	Gene:	CG46339 / 44359	FlyBaseID:	FBgn0285963	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_071587.2	Gene:	Enpep / 64017	RGDID:	621228	Length:	945	Species:	Rattus norvegicus

Alignment Length:	1011	Identity:	293/1011 - (28%)
Similarity:	477/1011 - (47%)	Gaps:	115/1011 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 KEVTPPSCITADHPDVNATPIQTAGWVSMNSPPPLQAATPTPMASPTPTNTPTVTTTLAMPASSE 252
            :|.:...||...|..:....:...|.:...|....::..|.  .:|.|:|.|..|:| |:|
  Rat     6 EEPSKKYCIKGKHVAIICATVVAVGLIVGLSVGLTRSCEPG--TTPAPSNPPPHTST-ALP---- 63

  Fly   253 KPEIRMVDPKVGDIPVVEPAAGEVEDNTTKPINRPLKLYEGWRPLHYSL----LIEPSVATSISN 313
             |:.:.|.|...|      .:||.::         .:|.:..:|:||.|    |:|....|.|.
  Rat    64 -PQDQNVCPDSDD------ESGEWKN---------FRLPDFIQPVHYDLEVKVLMEEDRYTGIV- 111

  Fly   314 GSLTIEIERDVSKVTSWEPIVLDVHNVSISNVRVIRALADGASNASEEQDLDFDSDYGEDNATFV 378
             |:::.:.:|...:  |    |.:....|:.:..:|      ..:.|:..:....:|.:.... |
  Rat   112 -SISVNLSKDTRDL--W----LHIRETRITKLPELR------RPSGEQVPIRRCFEYKKQEYV-V 162

  Fly   379 INLSKTLAVETQLRVL-LSLDFVSQVTDTLQGIYKTSYT-NPDTKNEEWMISTQFSPVDARRAFP 441
            |...:.||..:...|. |:::|...:..:|.|.|:|:|| :..||:   :.:|...|.|||::||
  Rat   163 IQAEEDLAATSGDSVYRLTIEFEGWLNGSLVGFYRTTYTEDGQTKS---IAATDHEPTDARKSFP 224

  Fly   442 CFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFRRGFIRDDFETTPKMPTYLVAFIVSNMVD 506
            |||.|:.||.::||::.|.::. ||||||..........:.:..|..:..|.||||.|.|.....
  Rat   225 CFDEPNKKATYNISLIHPKEYS-ALSNMPVEKEETLDNDWKKTTFMKSVPMSTYLVCFAVHQFTS 288

  Fly   507 SRLASQDSG--LTPRVEIWTRPQFVGMTHYAYKMVRKFLPYYEDFFGIKNKLPKIDLVSVPDFGF 569
            .:..|: ||  ||    ::.:|.......||..:.:....::||:|.::..|||:|.:::||||.
  Rat   289 IQRTSR-SGKPLT----VYVQPNQKQTAEYAANITKAVFDFFEDYFAMEYSLPKLDKIAIPDFGT 348

  Fly   570 AAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAGIIAHELAHQWFGNLVTPKWWDDLWLKEGF 634
            .|||||||:|:|::.||..   .|.|:|.:.|.||.::||||.||||||:||..|||||||.|||
  Rat   349 GAMENWGLVTYRETNLLYD---PLLSASSNQQRVASVVAHELVHQWFGNIVTMDWWDDLWLNEGF 410

  Fly   635 ACYMSYKALEHAHPEFQSMDTLTMLEFKESMEHDADNTSHAISFDVRSTNDVRRIFDPISYSKGT 699
            |.:..:..:.||..::|.:..:.:.:.....|.|:..:||.:...|.:..::..:||.||||||.
  Rat   411 ASFFEFLGVNHAEADWQMLSQVLLEDVLPVQEDDSLMSSHPVVVTVSTPAEITSVFDGISYSKGA 475

  Fly   700 ILLRMLNSIVGDVAFRSATRDLLKKFAYGNMDRDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWIT 764
            .:||||...:....|:...:..|:.|.:.|....|.|..|.:..::        .||::||:|.:
  Rat   476 SILRMLQDWITPEKFQKGCQIYLENFKFKNAKTSDFWDSLEKASNQ--------PVKEVMDTWTS 532

  Fly   765 QPGYPVVNVERRGADLVLRQERYLLPSKNTADQS--------TWFIPITFETDELRKGDNIPTHW 821
            |.|||||.|..:..   :.|:|:||..|  ||.|        ||.|||.:    ...|::..|.:
  Rat   533 QMGYPVVTVSGKQN---VTQKRFLLDYK--ADPSQPPSALGYTWNIPIKW----TENGNSNITVY 588

  Fly   822 MRSEDEEELIVGNVFAHSSNSDNVIYLNLNRQGYYRVNYDMTSW----LALKKNFSTLPRITRAQ 882
            .||..|...:..|:     :.|..:.:|.:..|:|||||:..:|    ..|..|........|:.
  Rat   589 YRSNREGITLNANL-----SGDGFLKINPDHIGFYRVNYEAETWDWIAETLSSNHMNFSSADRSS 648

  Fly   883 LLDDALHLSQAEYLTYDIPLTFLMELFDAVDDELLWIAAKPGLNYLI--YNLKREPAYETFRAFM 945
            .:|||..|::|:.|.|:..|. |.....:..|.|.|......::|:|  :...|| .|.....:.
  Rat   649 FIDDAFALARAQLLDYEKALN-LTRYLTSEKDFLPWERVISAVSYIISMFEDDRE-LYPLIETYF 711

  Fly   946 KFIVRPAFDHYGLHEPDNESHLQLKHRALVAYFACKFNYDRCTQKAQMKFREWMRDPKNNPIKPN 1010
            :..|:|..|..|..  |..||:....||.|..||||.........|...|..|::..::.|:  |
  Rat   712 RSQVKPIADSLGWQ--DTGSHITKLLRASVLGFACKMGAGEALGNASQLFEAWLKGNESIPV--N 772

  Fly  1011 LKSVIYCTSLA-EGSSPEWYFAYKQYKTTTSASEKEEILTSLGCTTKPWLLSKYLNMTINPTSGI 1074
            |:.::|...:. .|:...|.:..:||:.|:.|.|||::|..|.......||::||.|..:|  .|
  Rat   773 LRLLVYRYGMQNSGNEAAWNYTLEQYQKTSLAQEKEKLLYGLASVKDVTLLARYLEMLKDP--NI 835

  Fly  1075 LK-QDGALAFRAVASNAIGHEIAFDFLQGNIKEIVEYYGDGFSTLSE----MIKSLTIYMNKDYH 1134
            :| ||.....|.::.|:.|..:|::::|.|...:|..:     |:::    .|.::....|.:..
  Rat   836 IKTQDVFTVIRYISYNSYGKSMAWNWIQLNWDYLVNRF-----TINDRYLGRIVTIAEPFNTELQ 895

  Fly  1135 KHQLLDLAATCRKLGLHAVESAIELALEQVNNNIYW 1170
            ..|:....|.....|..|  ...|..||.|.|||.|
  Rat   896 LWQMQSFFAKYPNAGAGA--KPREQVLETVKNNIEW 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	Peptidase_M1	296..698	CDD:279741	134/409 (33%)
		M1_APN_2	297..769	CDD:189008	153/479 (32%)
		ERAP1_C	846..1138	CDD:288671	80/303 (26%)
Enpep	NP_071587.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..77		13/45 (29%)
		Peptidase_M1	84..474	CDD:279741	135/416 (32%)
		M1_APN_2	92..537	CDD:189008	153/479 (32%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q07075	349..353		2/3 (67%)
		ERAP1_C	608..922	CDD:288671	86/328 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920