Protein Alignment CG46339 and RNPEPL1

DIOPT Version :10

• Sequence 1: NP_001263001.1
• Gene: CG46339 / 44359
• FlyBaseID: FBgn0285963
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_060696.4
• Gene: RNPEPL1 / 57140
• HGNCID: 10079
• Length: 725
• Species: Homo sapiens
• Alignment Length: 660
• Identity: 142/660 - (21%)
• Similarity: 233/660 - (35%)
• Gaps: 158/660 - (23%)

  Fly   368 SDYGEDNATFVINLSKTLAVETQLRVLLSLDFVSQVTDTLQGIYKTSYTNPDTKNEEWM------ 426
            :|||   ::..:.|...|......:|:|                  .||:.|.....|:
Human   143 TDYG---SSLTVTLPPELQAHQPFQVIL------------------RYTSTDAPAIWWLDPELTY 186

  Fly   427 ------ISTQFSPVDARRAFPCFDRPDMKANFSISIVRPMQFKMALSNMPKSGSRRFRRGFIRDD 485
                  :.||...|..|..|||||.|.:|..:|..:..|...::.:|        ..|..::.::
Human   187 GCAKPFVFTQGHSVCNRSFFPCFDTPAVKCTYSAVVKAPSGVQVLMS--------ATRSAYMEEE 243

  Fly   486 ----FETTPKMPTYLVAFIVSNMVDSRLASQDSGLTPRVEIWTRPQFV-GMTHYAYKMVRKFLPY 545
                |.....:|.||||.:..::       :.:.:.||..:|..|..: ..|......|.::|..
Human   244 GVFHFHMEHPVPAYLVALVAGDL-------KPADIGPRSRVWAEPCLLPTATSKLSGAVEQWLSA 301

  Fly   546 YEDFFGIKNKLP----KIDLVSV-PDFGFAAMENWGLITFRDSALLVPEDLQLASSSEHMQVVAG 605
            .|..:|     |    :.|:|.: |.|...|||| ..:||..|::|         .|:...|:.
Human   302 AERLYG-----PYMWGRYDIVFLPPSFPIVAMEN-PCLTFIISSIL---------ESDEFLVID- 350

  Fly   606 IIAHELAHQWFGNLVTPKWWDDLWLKEGFACYMSYKALEHAH-PEFQSMDTLTMLEFKESMEHDA 669
             :.||:||.||||.||...|:::||.||.|.|...:.....: ..|..::|...|:.........
Human   351 -VIHEVAHSWFGNAVTNATWEEMWLSEGLATYAQRRITTETYGAAFTCLETAFRLDALHRQMKLL 414

  Fly   670 DNTSHAISFDVRSTNDVR--RIFDPISYSKGTILLRMLNSIVGD-VAFRSATRDLLKKFAYGNMD 731
            ...|......|:....|.  .:.:..:|.||...:..|:.:.|| ..|....|..::|:.:.::.
Human   415 GEDSPVSKLQVKLEPGVNPSHLMNLFTYEKGYCFVYYLSQLCGDPQRFDDFLRAYVEKYKFTSVV 479

  Fly   732 RDDLWAMLTRHGHEQGTLPKDLSVKQIMDSWITQPGYPVVNVE-RRGADLVLRQERYL------- 788
            ..||.........|......|.......:.|:...|.|:...: .:|:.|....|...
Human   480 AQDLLDSFLSFFPELKEQSVDCRAGLEFERWLNATGPPLAEPDLSQGSSLTRPVEALFQLWTAEP 544

  Fly   789 ----LPSKNTADQSTWFIPITFET----DELRKGDNIPTHWMRSEDEEELIVGNVFAHSSNSDNV 845
                ..|.:..|.|.|   .||:|    |.|..|..:|         :|:::.....:||..|
Human   545 LDQAAASASAIDISKW---RTFQTALFLDRLLDGSPLP---------QEVVMSLSKCYSSLLD-- 595

  Fly   846 IYLNLNRQGYYRVNYDMTSWLALKKNFSTLPRITRAQLLDDALHLSQAEYLTYDIPL-------- 902
               ::|.:...|       ||.:.......|.:.|.:...:    ||...: |.|||
Human   596 ---SMNAEIRIR-------WLQIVVRNDYYPDLHRVRRFLE----SQMSRM-YTIPLYEDLCTGA 645

  Fly   903 --TFLMELFDAVDDELLWIAAKPGLNYLIYNL-------KREPAYETFRAFMKFIVRPAFDHYGL 958
              :|.:|:|......|     .|.|...|..:       ..|||.|           |:.: .|.
Human   646 LKSFALEVFYQTQGRL-----HPNLRRAIQQILSQGLGSSTEPASE-----------PSTE-LGK 693

  Fly   959 HEPDNESHLQ 968
            .|.|.:|..|
Human   694 AEADTDSDAQ 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG46339	NP_001263001.1	M1_APN-Q_like	297..764	CDD:341064	93/421 (22%)
		ERAP1_C	846..1126	CDD:463368	29/140 (21%)
RNPEPL1	NP_060696.4	M1_LTA4H	29..512	CDD:341062	93/421 (22%)
		Leuk-A4-hydro_C	560..673	CDD:462686	31/146 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..699		8/34 (24%)